| 2021-03-06 | MortonvAyrChampionship · Scotland | 0–2 | Championship · Scotland |
| 2021-03-06 | MonzavPordenoneSerie B · Italy | 2–0 | Serie B · Italy |
| 2021-03-06 | HeartsvDundeeChampionship · Scotland | 2–1 | Championship · Scotland |
| 2021-03-06 | AntwerpvKortrijkPro League · Belgium | 4–2 | Pro League · Belgium |
| 2021-03-06 | DoncastervPlymouthLeague One · England | 2–1 | League One · England |
| 2021-03-06 | Waasland-BeverenvBeerschot VAPro League · Belgium | 1–2 | Pro League · Belgium |
| 2021-03-06 | FreiburgvRB LeipzigBundesliga · Germany | 0–3 | Bundesliga · Germany |
| 2021-03-06 | MorecambevCarlisleLeague Two · England | 3–1 | League Two · England |
| 2021-03-06 | PrestonvBournemouthChampionship · England | 1–1 | Championship · England |
| 2021-03-06 | HoffenheimvWolfsburgBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-03-06 | UTA AradvCFR ClujSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-03-06 | OFI CretevLarisaSuper League · Greece | 2–3 | Super League · Greece |
| 2021-03-06 | AlloavInverness CChampionship · Scotland | 1–1 | Championship · Scotland |
| 2021-03-06 | Sagan TosuvUrawa RedsJ1 League · Japan | 2–0 | J1 League · Japan |
| 2021-03-06 | BarrowvMansfieldLeague Two · England | 2–0 | League Two · England |
| 2021-03-06 | KarlsruhevSt Pauli2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2021-03-06 | Central CordobavBanfieldCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2021-03-06 | Godoy CruzvPlatenseCopa De La Liga Profesional · Argentina | 3–1 | Copa De La Liga Profesional · Argentina |
| 2021-03-06 | ChesterfieldvYeovilNational League · England | 3–0 | National League · England |
| 2021-03-06 | Ross CountyvKilmarnockPremiership · Scotland | 3–2 | Premiership · Scotland |
| 2021-03-06 | Yokohama FCvOita TrinitaJ1 League · Japan | 1–2 | J1 League · Japan |
| 2021-03-06 | BoavistavFamalicaoPrimeira Liga · Portugal | 3–0 | Primeira Liga · Portugal |
| 2021-03-06 | BradfordvBoltonLeague Two · England | 1–1 | League Two · England |
| 2021-03-06 | HeerenveenvDen HaagEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2021-03-06 | TorquayvHartlepoolNational League · England | 0–1 | National League · England |
| 2021-03-06 | HerthavAugsburgBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-03-06 | BarnsleyvBirminghamChampionship · England | 1–0 | Championship · England |
| 2021-03-06 | SalfordvScunthorpeLeague Two · England | 1–1 | League Two · England |
| 2021-03-06 | Young BoysvVaduzSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2021-03-06 | Colon Santa FEvAldosiviCopa De La Liga Profesional · Argentina | 2–1 | Copa De La Liga Profesional · Argentina |
| 2021-03-06 | TwentevWillem IIEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-03-06 | AccringtonvSwindonLeague One · England | 2–1 | League One · England |
| 2021-03-06 | ZaglebievJagielloniaEkstraklasa · Poland | 3–0 | Ekstraklasa · Poland |
| 2021-03-06 | GianninavPanathinaikosSuper League · Greece | 1–0 | Super League · Greece |
| 2021-03-06 | Nagoya GrampusvHokkaido Consadole SapporoJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-03-06 | ExetervLeyton OrientLeague Two · England | 4–0 | League Two · England |
| 2021-03-06 | AberdeenvHamiltonPremiership · Scotland | 0–0 | Premiership · Scotland |
| 2021-03-06 | NorwichvLutonChampionship · England | 3–0 | Championship · England |
| 2021-03-06 | VeneziavBresciaSerie B · Italy | 0–1 | Serie B · Italy |
| 2021-03-06 | HartbergvAdmiraBundesliga · Austria | 2–1 | Bundesliga · Austria |
| 2021-03-06 | ValladolidvGetafeLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-03-06 | TirolvSturm GrazBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2021-03-06 | Gil VicentevPortoPrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2021-03-06 | Sarmiento JuninvTalleres CordobaCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2021-03-06 | R. VolgogradvKhimkiPremier League · Russia | 0–0 | Premier League · Russia |
| 2021-03-06 | Virtus EntellavAscoliSerie B · Italy | 0–0 | Serie B · Italy |
| 2021-03-06 | EupenvOud-Heverlee LeuvenPro League · Belgium | 3–3 | Pro League · Belgium |
| 2021-03-06 | SpeziavBeneventoSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-03-06 | Shimizu S-PulsevAvispa FukuokaJ1 League · Japan | 2–2 | J1 League · Japan |
| 2021-03-06 | LincolnvCreweLeague One · England | 3–0 | League One · England |