| 2022-02-20 | MaritimovFamalicaoPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2022-02-20 | BresciavFrosinoneSerie B · Italy | 2–2 | Serie B · Italy |
| 2022-02-20 | AEKvGianninaSuper League · Greece | 2–0 | Super League · Greece |
| 2022-02-20 | Boca JuniorsvRosario CentralCopa De La Liga Profesional · Argentina | 2–1 | Copa De La Liga Profesional · Argentina |
| 2022-02-20 | IntervSassuoloSerie A · Italy | 0–2 | Serie A · Italy |
| 2022-02-20 | Sp GijonvPonferradinaLa Liga 2 · Spain | 2–3 | La Liga 2 · Spain |
| 2022-02-20 | LorientvMontpellierLigue 1 · France | 0–1 | Ligue 1 · France |
| 2022-02-20 | NicevAngersLigue 1 · France | 1–0 | Ligue 1 · France |
| 2022-02-20 | TondelavSp BragaPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2022-02-20 | Chindia TargovistevFC BotosaniSuperliga · Romania | 1–1 | Superliga · Romania |
| 2022-02-20 | St TruidenvOud-Heverlee LeuvenPro League · Belgium | 2–0 | Pro League · Belgium |
| 2022-02-20 | PlatensevSarmiento JuninCopa De La Liga Profesional · Argentina | 2–0 | Copa De La Liga Profesional · Argentina |
| 2022-02-20 | SilkeborgvVejleSuperliga · Denmark | 3–0 | Superliga · Denmark |
| 2022-02-20 | Dundee UnitedvRangersPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2022-02-20 | CelticvDundeePremiership · Scotland | 3–2 | Premiership · Scotland |
| 2022-02-20 | RennesvTroyesLigue 1 · France | 4–1 | Ligue 1 · France |
| 2022-02-20 | FenerbahcevHataysporSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2022-02-20 | FiorentinavAtalantaSerie A · Italy | 1–0 | Serie A · Italy |
| 2022-02-20 | GaziantepvAd. DemirsporSüper Lig · Turkey | 0–3 | Süper Lig · Turkey |
| 2022-02-20 | GrasshoppersvYoung BoysSuper League · Switzerland | 2–2 | Super League · Switzerland |
| 2022-02-20 | UtrechtvVitesseEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2022-02-20 | ComovCosenzaSerie B · Italy | 2–1 | Serie B · Italy |
| 2022-02-20 | PSV EindhovenvHeerenveenEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2022-02-20 | HerthavRB LeipzigBundesliga · Germany | 1–6 | Bundesliga · Germany |
| 2022-02-20 | Volos NFCvOlympiakosSuper League · Greece | 0–1 | Super League · Greece |
| 2022-02-20 | EupenvClub BruggePro League · Belgium | 1–3 | Pro League · Belgium |
| 2022-02-20 | Warta PoznanvRadomiak RadomEkstraklasa · Poland | 3–1 | Ekstraklasa · Poland |
| 2022-02-20 | KaragumrukvSivassporSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2022-02-20 | Gornik Z.vRakowEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2022-02-20 | FuenlabradavAlcorconLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |
| 2022-02-20 | AnderlechtvGenkPro League · Belgium | 2–0 | Pro League · Belgium |
| 2022-02-20 | BurgosvOviedoLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2022-02-20 | Sturm GrazvSK RapidBundesliga · Austria | 2–2 | Bundesliga · Austria |
| 2022-02-20 | DortmundvM'gladbachBundesliga · Germany | 6–0 | Bundesliga · Germany |
| 2022-02-20 | A. KlagenfurtvAltachBundesliga · Austria | 2–0 | Bundesliga · Austria |
| 2022-02-19 | KortrijkvWaregemPro League · Belgium | 5–0 | Pro League · Belgium |
| 2022-02-19 | Club TijuanavNecaxaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2022-02-19 | QPRvHullChampionship · England | 1–1 | Championship · England |
| 2022-02-19 | PanetolikosvPanathinaikosSuper League · Greece | 1–0 | Super League · Greece |
| 2022-02-19 | Willem IIvAjaxEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2022-02-19 | PerugiavCremoneseSerie B · Italy | 0–0 | Serie B · Italy |
| 2022-02-19 | LensvLyonLigue 1 · France | 1–1 | Ligue 1 · France |
| 2022-02-19 | ArsenalvBrentfordPremier League · England | 2–1 | Premier League · England |
| 2022-02-19 | Forest GreenvWalsallLeague Two · England | 0–1 | League Two · England |
| 2022-02-19 | Estudiantes L.P.vLanusCopa De La Liga Profesional · Argentina | 2–1 | Copa De La Liga Profesional · Argentina |
| 2022-02-19 | Avispa FukuokavIwataJ1 League · Japan | 1–1 | J1 League · Japan |
| 2022-02-19 | TenerifevIbizaLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2022-02-19 | FC KolnvEin FrankfurtBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2022-02-19 | Notts CountyvEastleighNational League · England | 2–0 | National League · England |
| 2022-02-19 | CarlislevSwindonLeague Two · England | 0–3 | League Two · England |