| 2016-02-20 | GatesheadvAldershotNational League · England | 3–2 | National League · England |
| 2016-02-20 | AntalyasporvRizesporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2016-02-20 | HoffenheimvMainzBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2016-02-20 | East StirlingvAnnan AthleticLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2016-02-20 | VeronavChievoSerie A · Italy | 3–1 | Serie A · Italy |
| 2016-02-20 | Raith RvsvLivingstonChampionship · Scotland | 2–0 | Championship · Scotland |
| 2016-02-20 | Asteras TripolisvGianninaSuper League · Greece | 0–0 | Super League · Greece |
| 2016-02-20 | CardiffvBrightonChampionship · England | 4–1 | Championship · England |
| 2016-02-20 | HuddersfieldvWolvesChampionship · England | 1–0 | Championship · England |
| 2016-02-20 | Paris SGvReimsLigue 1 · France | 4–1 | Ligue 1 · France |
| 2016-02-20 | LokerenvGenkPro League · Belgium | 0–0 | Pro League · Belgium |
| 2016-02-20 | Poli IasivPoli TimisoaraSuperliga · Romania | 1–1 | Superliga · Romania |
| 2016-02-20 | San LorenzovVelez SarsfieldLiga Profesional · Argentina | 3–2 | Liga Profesional · Argentina |
| 2016-02-20 | KidderminstervChesterNational League · England | 2–2 | National League · England |
| 2016-02-20 | FulhamvCharltonChampionship · England | 3–0 | Championship · England |
| 2016-02-20 | Pro VercellivVirtus EntellaSerie B · Italy | 2–3 | Serie B · Italy |
| 2016-02-20 | ToulousevAjaccio GFCOLigue 1 · France | 1–1 | Ligue 1 · France |
| 2016-02-20 | YeovilvPortsmouthLeague Two · England | 1–1 | League Two · England |
| 2016-02-20 | TwentevCambuurEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2016-02-20 | Fleetwood TownvScunthorpeLeague One · England | 2–1 | League One · England |
| 2016-02-20 | KasimpasavEskisehirsporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2016-02-20 | StandardvCharleroiPro League · Belgium | 3–0 | Pro League · Belgium |
| 2016-02-20 | East FifevStirlingLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2016-02-20 | LincolnvSouthportNational League · England | 3–1 | National League · England |
| 2016-02-20 | Club AmericavCruz AzulLiga MX · Mexico | 3–3 | Liga MX · Mexico |
| 2016-02-20 | Dundee UnitedvHeartsPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2016-02-20 | KortrijkvSt TruidenPro League · Belgium | 3–0 | Pro League · Belgium |
| 2016-02-20 | IntervSampdoriaSerie A · Italy | 3–1 | Serie A · Italy |
| 2016-02-20 |  MonacovTroyesLigue 1 · France | 3–1 | Ligue 1 · France |
| 2016-02-20 | M'gladbachvFC KolnBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2016-02-20 | Din. BucurestivConcordiaSuperliga · Romania | 4–0 | Superliga · Romania |
| 2016-02-20 | Bristol RvsvMorecambeLeague Two · England | 2–1 | League Two · England |
| 2016-02-20 | Milton Keynes DonsvBristol CityChampionship · England | 0–2 | Championship · England |
| 2016-02-20 | AcademicavRio AvePrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2016-02-20 | Crawley TownvPlymouthLeague Two · England | 1–1 | League Two · England |
| 2016-02-20 | KarlsruhevBraunschweig2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2016-02-20 | PonferradinavCordobaLa Liga 2 · Spain | 1–3 | La Liga 2 · Spain |
| 2016-02-20 | KaiserslauternvHeidenheim2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2016-02-20 | WalsallvWiganLeague One · England | 1–2 | League One · England |
| 2016-02-20 | AZ AlkmaarvGroningenEredivisie · Netherlands | 4–1 | Eredivisie · Netherlands |
| 2016-02-20 | HeerenveenvNijmegenEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2016-02-20 | ExetervNewport CountyLeague Two · England | 1–1 | League Two · England |
| 2016-02-20 | St MirrenvDumbartonChampionship · Scotland | 1–0 | Championship · Scotland |
| 2016-02-20 | Gimnasia L.P.vOlimpo Bahia BlancaLiga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2016-02-20 | AlbacetevMirandesLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2016-02-20 | Club TijuanavMonarcasLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2016-02-20 | BoltonvQPRChampionship · England | 1–1 | Championship · England |
| 2016-02-20 | Notts CountyvLeyton OrientLeague Two · England | 0–1 | League Two · England |
| 2016-02-20 | Termalica B-B.vCracoviaEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2016-02-20 | BarnsleyvDoncasterLeague One · England | 1–0 | League One · England |