| 2022-02-21 | Randers FCvViborgSuperliga · Denmark | 0–1 | Superliga · Denmark |
| 2022-02-21 | Barracas CentralvTigreCopa De La Liga Profesional · Argentina | 0–2 | Copa De La Liga Profesional · Argentina |
| 2022-02-21 | TolucavCruz AzulLiga MX · Mexico | 1–4 | Liga MX · Mexico |
| 2022-02-21 | CagliarivNapoliSerie A · Italy | 1–1 | Serie A · Italy |
| 2022-02-21 | Newells Old BoysvRiver PlateCopa De La Liga Profesional · Argentina | 0–2 | Copa De La Liga Profesional · Argentina |
| 2022-02-21 | GoztepvGalatasaraySüper Lig · Turkey | 2–3 | Süper Lig · Turkey |
| 2022-02-21 | AmorebietavLeganesLa Liga 2 · Spain | 1–3 | La Liga 2 · Spain |
| 2022-02-21 | CeltavLevanteLa Liga · Spain | 1–1 | La Liga · Spain |
| 2022-02-21 | ToulousevLe HavreLigue 2 · France | 4–0 | Ligue 2 · France |
| 2022-02-20 | MarseillevClermontLigue 1 · France | 0–2 | Ligue 1 · France |
| 2022-02-20 | LamiavApollonSuper League · Greece | 1–2 | Super League · Greece |
| 2022-02-20 | Velez SarsfieldvIndependienteCopa De La Liga Profesional · Argentina | 0–0 | Copa De La Liga Profesional · Argentina |
| 2022-02-20 | EspanolvSevillaLa Liga · Spain | 1–1 | La Liga · Spain |
| 2022-02-20 | Tigres UANLvAtl. San LuisLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2022-02-20 | UdinesevLazioSerie A · Italy | 1–1 | Serie A · Italy |
| 2022-02-20 | DarmstadtvHansa Rostock2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2022-02-20 | St PaulivHannover2. Bundesliga · Germany | 0–3 | 2. Bundesliga · Germany |
| 2022-02-20 | SalzburgvWolfsberger ACBundesliga · Austria | 2–0 | Bundesliga · Austria |
| 2022-02-20 | AlanyasporvTrabzonsporSüper Lig · Turkey | 0–4 | Süper Lig · Turkey |
| 2022-02-20 | Club AmericavPachucaLiga MX · Mexico | 1–3 | Liga MX · Mexico |
| 2022-02-20 | LeedsvMan UnitedPremier League · England | 2–4 | Premier League · England |
| 2022-02-20 | Bayern MunichvGreuther FurthBundesliga · Germany | 4–1 | Bundesliga · Germany |
| 2022-02-20 | ArisvPAOKSuper League · Greece | 0–0 | Super League · Greece |
| 2022-02-20 | FC CopenhagenvOdenseSuperliga · Denmark | 2–0 | Superliga · Denmark |
| 2022-02-20 | CFR ClujvFC Rapid BucurestiSuperliga · Romania | 2–1 | Superliga · Romania |
| 2022-02-20 | ServettevLuzernSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2022-02-20 | ReimsvBrestLigue 1 · France | 1–1 | Ligue 1 · France |
| 2022-02-20 | Lechia GdanskvLech PoznanEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2022-02-20 | Fortuna DusseldorfvErzgebirge Aue2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2022-02-20 | Sp LisbonvEstorilPrimeira Liga · Portugal | 3–0 | Primeira Liga · Portugal |
| 2022-02-20 | AntwerpvMechelenPro League · Belgium | 1–2 | Pro League · Belgium |
| 2022-02-20 | LeccevCrotoneSerie B · Italy | 3–0 | Serie B · Italy |
| 2022-02-20 | ZwollevGroningenEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2022-02-20 | HuescavLugoLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2022-02-20 | VeneziavGenoaSerie A · Italy | 1–1 | Serie A · Italy |
| 2022-02-20 | SionvZurichSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2022-02-20 | CittadellavBeneventoSerie B · Italy | 0–1 | Serie B · Italy |
| 2022-02-20 | St EtiennevStrasbourgLigue 1 · France | 2–2 | Ligue 1 · France |
| 2022-02-20 | FeyenoordvCambuurEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2022-02-20 | AlmeriavMirandesLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2022-02-20 | Ath BilbaovSociedadLa Liga · Spain | 4–0 | La Liga · Spain |
| 2022-02-20 | WolvesvLeicesterPremier League · England | 2–1 | Premier League · England |
| 2022-02-20 | Bordeauxv MonacoLigue 1 · France | 1–1 | Ligue 1 · France |
| 2022-02-20 | TwentevGo Ahead EaglesEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2022-02-20 | MidtjyllandvAalborgSuperliga · Denmark | 0–2 | Superliga · Denmark |
| 2022-02-20 | NordsjaellandvBrondbySuperliga · Denmark | 0–2 | Superliga · Denmark |
| 2022-02-20 | BetisvMallorcaLa Liga · Spain | 2–1 | La Liga · Spain |
| 2022-02-20 | MoreirensevPortoPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2022-02-20 | Club LeonvGuadalajara ChivasLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2022-02-20 | ValenciavBarcelonaLa Liga · Spain | 1–4 | La Liga · Spain |