| 2021-03-07 | GironavAlmeriaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-03-07 | West BromvNewcastlePremier League · England | 0–0 | Premier League · England |
| 2021-03-07 | MalagavSabadellLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-03-07 | SampdoriavCagliariSerie A · Italy | 2–2 | Serie A · Italy |
| 2021-03-07 | LausannevSionSuper League · Switzerland | 1–3 | Super League · Switzerland |
| 2021-03-07 | NordsjaellandvHorsensSuperliga · Denmark | 2–2 | Superliga · Denmark |
| 2021-03-07 | MonterreyvQueretaroLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-03-07 | HataysporvKayserisporSüper Lig · Turkey | 1–3 | Süper Lig · Turkey |
| 2021-03-07 | PAOKvArisSuper League · Greece | 2–2 | Super League · Greece |
| 2021-03-07 | CrotonevTorinoSerie A · Italy | 4–2 | Serie A · Italy |
| 2021-03-07 | Spartak MoscowvKrasnodarPremier League · Russia | 6–1 | Premier League · Russia |
| 2021-03-07 | San LorenzovHuracanCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2021-03-07 | UralvUfaPremier League · Russia | 0–0 | Premier League · Russia |
| 2021-03-07 | RomavGenoaSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-03-07 | Arsenal SarandivEstudiantes L.P.Copa De La Liga Profesional · Argentina | 0–5 | Copa De La Liga Profesional · Argentina |
| 2021-03-07 | GenkvCercle BruggePro League · Belgium | 2–0 | Pro League · Belgium |
| 2021-03-07 | LiverpoolvFulhamPremier League · England | 0–1 | Premier League · England |
| 2021-03-07 | Dundee UnitedvCelticPremiership · Scotland | 0–0 | Premiership · Scotland |
| 2021-03-07 | Man CityvMan UnitedPremier League · England | 0–2 | Premier League · England |
| 2021-03-07 | MaritimovMoreirensePrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2021-03-07 | TottenhamvCrystal PalacePremier League · England | 4–1 | Premier League · England |
| 2021-03-07 | Ath BilbaovGranadaLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-03-07 | Gimnasia L.P.vDefensa y JusticiaCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2021-03-07 | MallorcavCartagenaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-03-07 | BrondbyvFC CopenhagenSuperliga · Denmark | 2–1 | Superliga · Denmark |
| 2021-03-07 | KaragumrukvAnkaragucuSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-03-07 | Yokohama F. MarinosvSanfrecce HiroshimaJ1 League · Japan | 3–3 | J1 League · Japan |
| 2021-03-07 | GalatasarayvSivassporSüper Lig · Turkey | 2–2 | Süper Lig · Turkey |
| 2021-03-07 | MouscronvStandardPro League · Belgium | 1–0 | Pro League · Belgium |
| 2021-03-07 | GenclerbirligivBuyuksehyrSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-03-07 | VitessevAZ AlkmaarEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2021-03-07 | LuzernvSt. GallenSuper League · Switzerland | 4–2 | Super League · Switzerland |
| 2021-03-07 | LuganovZurichSuper League · Switzerland | 0–1 | Super League · Switzerland |
| 2021-03-07 | MidtjyllandvAarhusSuperliga · Denmark | 0–1 | Superliga · Denmark |
| 2021-03-07 | Slask WroclawvLegiaEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2021-03-07 | AjaxvGroningenEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2021-03-07 | Fortuna DusseldorfvNurnberg2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2021-03-07 | Piast GliwicevStal MielecEkstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2021-03-07 | Ath MadridvReal MadridLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-03-07 | FC KolnvWerder BremenBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-03-07 | PanetolikosvVolos NFCSuper League · Greece | 1–0 | Super League · Greece |
| 2021-03-07 | SociedadvLevanteLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-03-07 | AnderlechtvMechelenPro League · Belgium | 1–1 | Pro League · Belgium |
| 2021-03-07 | Mazatlan FCvGuadalajara ChivasLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-03-07 | VejlevOdenseSuperliga · Denmark | 2–0 | Superliga · Denmark |
| 2021-03-07 | RiedvWolfsberger ACBundesliga · Austria | 0–4 | Bundesliga · Austria |
| 2021-03-07 | HuescavCeltaLa Liga · Spain | 3–4 | La Liga · Spain |
| 2021-03-07 | HeraclesvZwolleEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2021-03-07 | Pogon SzczecinvLech PoznanEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2021-03-07 | ReggianavLecceSerie B · Italy | 0–4 | Serie B · Italy |