| 2022-02-22 | AldershotvDover AthleticNational League · England | 0–0 | National League · England |
| 2022-02-22 | SolihullvWealdstoneNational League · England | 2–1 | National League · England |
| 2022-02-22 | SunderlandvBurtonLeague One · England | 1–1 | League One · England |
| 2022-02-22 | Bristol CityvCoventryChampionship · England | 1–2 | Championship · England |
| 2022-02-22 | PrestonvNott'm ForestChampionship · England | 0–0 | Championship · England |
| 2022-02-22 | San LorenzovDefensa y JusticiaCopa De La Liga Profesional · Argentina | 3–4 | Copa De La Liga Profesional · Argentina |
| 2022-02-22 | BarnetvKings LynnNational League · England | 0–0 | National League · England |
| 2022-02-22 | WycombevWiganLeague One · England | 1–3 | League One · England |
| 2022-02-22 | MiddlesbroughvWest BromChampionship · England | 2–1 | Championship · England |
| 2022-02-22 | ChesterfieldvWrexhamNational League · England | 0–2 | National League · England |
| 2022-02-22 | FalkirkvPeterheadLeague One · Scotland | 1–1 | League One · Scotland |
| 2022-02-22 | ShrewsburyvPortsmouthLeague One · England | 1–2 | League One · England |
| 2022-02-22 | CrewevOxfordLeague One · England | 0–1 | League One · England |
| 2022-02-22 | GillinghamvAFC WimbledonLeague One · England | 0–0 | League One · England |
| 2022-02-22 | MaidenheadvYeovilNational League · England | 1–1 | National League · England |
| 2022-02-22 | ReadingvBirminghamChampionship · England | 2–1 | Championship · England |
| 2022-02-22 | PatronatovTalleres CordobaCopa De La Liga Profesional · Argentina | 0–0 | Copa De La Liga Profesional · Argentina |
| 2022-02-22 | Kelty HeartsvCowdenbeathLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2022-02-22 | BoltonvLincolnLeague One · England | 3–1 | League One · England |
| 2022-02-22 | BuyuksehyrvKonyasporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2022-02-22 | BradfordvHarrogateLeague Two · England | 1–3 | League Two · England |
| 2022-02-22 | WeymouthvBromleyNational League · England | 2–2 | National League · England |
| 2022-02-22 | ScunthorpevNorthamptonLeague Two · England | 0–0 | League Two · England |
| 2022-02-22 | PordenonevMonzaSerie B · Italy | 1–4 | Serie B · Italy |
| 2022-02-22 | SpalvTernanaSerie B · Italy | 5–1 | Serie B · Italy |
| 2022-02-22 | ColchestervHartlepoolLeague Two · England | 1–2 | League Two · England |
| 2022-02-22 | Dag and RedvWokingNational League · England | 1–1 | National League · England |
| 2022-02-22 | RochdalevPort ValeLeague Two · England | 1–1 | League Two · England |
| 2022-02-22 | HullvBarnsleyChampionship · England | 0–2 | Championship · England |
| 2022-02-22 | PisavParmaSerie B · Italy | 0–0 | Serie B · Italy |
| 2022-02-22 | IpswichvCheltenhamLeague One · England | 0–0 | League One · England |
| 2022-02-22 | CambridgevPlymouthLeague One · England | 2–0 | League One · England |
| 2022-02-22 | PartickvMortonChampionship · Scotland | 0–1 | Championship · Scotland |
| 2022-02-22 | CremonesevVicenzaSerie B · Italy | 0–0 | Serie B · Italy |
| 2022-02-22 | Notts CountyvHalifaxNational League · England | 1–1 | National League · England |
| 2022-02-22 | TorquayvBoreham WoodNational League · England | 0–0 | National League · England |
| 2022-02-22 | Union de Santa FevAtl. TucumanCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2022-02-22 | RotherhamvMorecambeLeague One · England | 2–0 | League One · England |
| 2022-02-22 | EastleighvSouthendNational League · England | 1–1 | National League · England |
| 2022-02-22 | AlessandriavPerugiaSerie B · Italy | 1–2 | Serie B · Italy |
| 2022-02-22 | DoncastervAccringtonLeague One · England | 2–0 | League One · England |
| 2022-02-22 | CharltonvMilton Keynes DonsLeague One · England | 0–2 | League One · England |
| 2022-02-21 | Santa ClaravPortimonensePrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2022-02-21 | BolognavSpeziaSerie A · Italy | 2–1 | Serie A · Italy |
| 2022-02-21 | AtlasvUNAM PumasLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2022-02-21 | Academica ClincenivUniv. CraiovaSuperliga · Romania | 1–3 | Superliga · Romania |
| 2022-02-21 | BanfieldvGimnasia L.P.Copa De La Liga Profesional · Argentina | 4–0 | Copa De La Liga Profesional · Argentina |
| 2022-02-21 | Farul ConstantavFC ArgesSuperliga · Romania | 0–1 | Superliga · Romania |
| 2022-02-21 | Godoy CruzvAldosiviCopa De La Liga Profesional · Argentina | 0–2 | Copa De La Liga Profesional · Argentina |
| 2022-02-21 | WislavLecznaEkstraklasa · Poland | 0–0 | Ekstraklasa · Poland |