| 2016-02-21 | Gornik Z.vRuchEkstraklasa · Poland | 0–2 | Ekstraklasa · Poland |
| 2016-02-21 | Ath MadridvVillarrealLa Liga · Spain | 0–0 | La Liga · Spain |
| 2016-02-21 | HibernianvAlloaChampionship · Scotland | 3–0 | Championship · Scotland |
| 2016-02-21 | SetubalvNacionalPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2016-02-21 | LillevLyonLigue 1 · France | 1–0 | Ligue 1 · France |
| 2016-02-21 | PlataniasvPanetolikosSuper League · Greece | 1–1 | Super League · Greece |
| 2016-02-21 | Queen of SthvRangersChampionship · Scotland | 0–1 | Championship · Scotland |
| 2016-02-21 | TondelavMaritimoPrimeira Liga · Portugal | 3–4 | Primeira Liga · Portugal |
| 2016-02-21 | UNAM PumasvSantos LagunaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2016-02-21 | PortovMoreirensePrimeira Liga · Portugal | 3–2 | Primeira Liga · Portugal |
| 2016-02-21 | ValladolidvNumanciaLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |
| 2016-02-21 | MalagavReal MadridLa Liga · Spain | 1–1 | La Liga · Spain |
| 2016-02-21 | Sturm GrazvSK RapidBundesliga · Austria | 0–2 | Bundesliga · Austria |
| 2016-02-21 |  Guyanav SurinameFriendly | 2–0 | Friendly |
| 2016-02-21 | PetrolulvViitorul ConstantaSuperliga · Romania | 1–2 | Superliga · Romania |
| 2016-02-21 | OostendevGentPro League · Belgium | 5–2 | Pro League · Belgium |
| 2016-02-21 | Ath BilbaovSociedadLa Liga · Spain | 0–1 | La Liga · Spain |
| 2016-02-21 | BielefeldvPaderborn2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2016-02-21 | Club LeonvTolucaLiga MX · Mexico | 5–1 | Liga MX · Mexico |
| 2016-02-21 | TorinovCarpiSerie A · Italy | 0–0 | Serie A · Italy |
| 2016-02-21 | ZaglebievLegiaEkstraklasa · Poland | 1–2 | Ekstraklasa · Poland |
| 2016-02-21 | Munich 1860vBochum2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2016-02-21 | AtlasvPachucaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2016-02-21 | IndependientevRacing ClubLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2016-02-21 | ElchevHuescaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2016-02-21 | BelgranovBanfieldLiga Profesional · Argentina | 0–0 | Liga Profesional · Argentina |
| 2016-02-21 | RomavPalermoSerie A · Italy | 5–0 | Serie A · Italy |
| 2016-02-21 | FeyenoordvRodaEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2016-02-21 | OlympiakosvAtromitosSuper League · Greece | 4–0 | Super League · Greece |
| 2016-02-21 | Akhisar BelediyesporvBuyuksehyrSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2016-02-21 | VallecanovSevillaLa Liga · Spain | 2–2 | La Liga · Spain |
| 2016-02-21 | PueblavDorados de SinaloaLiga MX · Mexico | 3–2 | Liga MX · Mexico |
| 2016-02-21 | FrosinonevLazioSerie A · Italy | 0–0 | Serie A · Italy |
| 2016-02-21 | BelenensesvAroucaPrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2016-02-21 | LeverkusenvDortmundBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2016-02-21 | Godoy CruzvColon Santa FELiga Profesional · Argentina | 4–1 | Liga Profesional · Argentina |
| 2016-02-21 | Waasland-BeverenvAnderlechtPro League · Belgium | 1–0 | Pro League · Belgium |
| 2016-02-21 | Boca JuniorsvNewells Old BoysLiga Profesional · Argentina | 4–1 | Liga Profesional · Argentina |
| 2016-02-21 | GrasshoppersvSionSuper League · Switzerland | 3–0 | Super League · Switzerland |
| 2016-02-21 | SalernitanavCrotoneSerie B · Italy | 1–1 | Serie B · Italy |
| 2016-02-21 | UtrechtvWillem IIEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2016-02-21 | SassuolovEmpoliSerie A · Italy | 3–2 | Serie A · Italy |
| 2016-02-21 | LuzernvSt. GallenSuper League · Switzerland | 0–1 | Super League · Switzerland |
| 2016-02-21 | CFR ClujvTargu MuresSuperliga · Romania | 1–0 | Superliga · Romania |
| 2016-02-20 | EspanolvLa CorunaLa Liga · Spain | 1–0 | La Liga · Spain |
| 2016-02-20 | IngolstadtvWerder BremenBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2016-02-20 | Bayern MunichvDarmstadtBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2016-02-20 | PSV EindhovenvHeraclesEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2016-02-20 | Austria ViennavMattersburgBundesliga · Austria | 2–2 | Bundesliga · Austria |
| 2016-02-20 | Welling UnitedvWrexhamNational League · England | 0–2 | National League · England |