| 2016-11-27 | SionvBaselSuper League · Switzerland | 1–2 | Super League · Switzerland |
| 2016-11-27 | Sarmiento JuninvGodoy CruzLiga Profesional · Argentina | 2–2 | Liga Profesional · Argentina |
| 2016-11-27 | OsasunavAth MadridLa Liga · Spain | 0–3 | La Liga · Spain |
| 2016-11-27 | AngersvSt EtienneLigue 1 · France | 1–2 | Ligue 1 · France |
| 2016-11-27 | ArsenalvBournemouthPremier League · England | 3–1 | Premier League · England |
| 2016-11-27 | HeerenveenvAjaxEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2016-11-27 | SouthamptonvEvertonPremier League · England | 1–0 | Premier League · England |
| 2016-11-27 | SociedadvBarcelonaLa Liga · Spain | 1–1 | La Liga · Spain |
| 2016-11-27 | TondelavGuimaraesPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2016-11-27 | FigueirensevFluminenseSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2016-11-27 | Santa CruzvGremioSerie A · Brazil | 5–1 | Serie A · Brazil |
| 2016-11-27 | Sparta RotterdamvRodaEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2016-11-27 | EsbjergvNordsjaellandSuperliga · Denmark | 2–2 | Superliga · Denmark |
| 2016-11-27 | Atletico-MGvSao PauloSerie A · Brazil | 1–2 | Serie A · Brazil |
| 2016-11-27 | FCSBvFC BotosaniSuperliga · Romania | 0–0 | Superliga · Romania |
| 2016-11-27 | Club TijuanavClub LeonLiga MX · Mexico | 3–2 | Liga MX · Mexico |
| 2016-11-27 | Krylya SovetovvTomskPremier League · Russia | 3–0 | Premier League · Russia |
| 2016-11-27 | Man UnitedvWest HamPremier League · England | 1–1 | Premier League · England |
| 2016-11-27 | San LorenzovBoca JuniorsLiga Profesional · Argentina | 1–2 | Liga Profesional · Argentina |
| 2016-11-27 | HerthavMainzBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2016-11-27 | StandardvWaregemPro League · Belgium | 4–1 | Pro League · Belgium |
| 2016-11-27 | BraunschweigvMunich 18602. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2016-11-27 | GenclerbirligivTrabzonsporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2016-11-27 | KaiserslauternvKarlsruhe2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2016-11-27 | OostendevGenkPro League · Belgium | 6–0 | Pro League · Belgium |
| 2016-11-27 | InternacionalvCruzeiroSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2016-11-27 | SK RapidvSturm GrazBundesliga · Austria | 1–2 | Bundesliga · Austria |
| 2016-11-27 | CrotonevSampdoriaSerie A · Italy | 1–1 | Serie A · Italy |
| 2016-11-26 | Rosario CentralvOlimpo Bahia BlancaLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2016-11-26 | BelenensesvPortoPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2016-11-26 | ReadingvBristol CityChampionship · England | 2–1 | Championship · England |
| 2016-11-26 | WycombevHartlepoolLeague Two · England | 2–0 | League Two · England |
| 2016-11-26 | EmpolivMilanSerie A · Italy | 1–4 | Serie A · Italy |
| 2016-11-26 | LugovTenerifeLa Liga 2 · Spain | 1–3 | La Liga 2 · Spain |
| 2016-11-26 | SolihullvNorth FerribyNational League · England | 2–0 | National League · England |
| 2016-11-26 | RuchvJagielloniaEkstraklasa · Poland | 1–2 | Ekstraklasa · Poland |
| 2016-11-26 | TorinovChievoSerie A · Italy | 2–1 | Serie A · Italy |
| 2016-11-26 | EspanolvLeganesLa Liga · Spain | 3–0 | La Liga · Spain |
| 2016-11-26 | NacionalvEstorilPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2016-11-26 | ValladolidvAlmeriaLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2016-11-26 | AlcorconvOviedoLa Liga 2 · Spain | 5–1 | La Liga 2 · Spain |
| 2016-11-26 | BrightonvFulhamChampionship · England | 2–1 | Championship · England |
| 2016-11-26 | BlackpoolvNewport CountyLeague Two · England | 4–1 | League Two · England |
| 2016-11-26 | MattersburgvAltachBundesliga · Austria | 1–2 | Bundesliga · Austria |
| 2016-11-26 | Botafogo RJvPonte PretaSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2016-11-26 | DresdenvBochum2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2016-11-26 | DerbyvNorwichChampionship · England | 1–0 | Championship · England |
| 2016-11-26 | America MGvSport RecifeSerie A · Brazil | 2–2 | Serie A · Brazil |
| 2016-11-26 | Lokomotiv MoscowvUralPremier League · Russia | 1–1 | Premier League · Russia |
| 2016-11-26 | MetzvLorientLigue 1 · France | 3–3 | Ligue 1 · France |