| 2010-11-13 | MontpelliervToulouseLigue 1 · France | 1–0 | Ligue 1 · France |
| 2010-11-13 | MacclesfieldvAldershotLeague Two · England | 2–0 | League Two · England |
| 2010-11-13 | BielefeldvOsnabruck2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2010-11-13 | AcademicavSp LisbonPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2010-11-13 | GerminalvStandardPro League · Belgium | 0–1 | Pro League · Belgium |
| 2010-11-13 | SouthendvAccringtonLeague Two · England | 1–1 | League Two · England |
| 2010-11-13 | CharleroivWesterloPro League · Belgium | 0–1 | Pro League · Belgium |
| 2010-11-13 | StevenagevShrewsburyLeague Two · England | 1–1 | League Two · England |
| 2010-11-13 | MarseillevLensLigue 1 · France | 1–1 | Ligue 1 · France |
| 2010-11-13 | PadovavFrosinoneSerie B · Italy | 3–1 | Serie B · Italy |
| 2010-11-13 | HamiltonvInverness CPremiership · Scotland | 1–3 | Premiership · Scotland |
| 2010-11-13 | Las PalmasvGironaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2010-11-13 | GuimaraesvSp BragaPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2010-11-13 | St JohnstonevHeartsPremiership · Scotland | 0–2 | Premiership · Scotland |
| 2010-11-13 | MainzvHannoverBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2010-11-13 | BursasporvTrabzonsporSüper Lig · Turkey | 0–2 | Süper Lig · Turkey |
| 2010-11-13 | Ross CountyvDundeeChampionship · Scotland | 0–3 | Championship · Scotland |
| 2010-11-13 | BucasporvAnkaragucuSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2010-11-13 | Ath MadridvOsasunaLa Liga · Spain | 3–0 | La Liga · Spain |
| 2010-11-13 |  MonacovArlesLigue 1 · France | 0–0 | Ligue 1 · France |
| 2010-11-13 | Hayes & YeadingvGrimsbyNational League · England | 0–3 | National League · England |
| 2010-11-13 | Club BruggevLiersePro League · Belgium | 2–0 | Pro League · Belgium |
| 2010-11-13 | BrechinvForfarLeague One · Scotland | 0–0 | League One · Scotland |
| 2010-11-13 | PanioniosvAtromitosSuper League · Greece | 0–1 | Super League · Greece |
| 2010-11-13 | PartickvMortonChampionship · Scotland | 0–0 | Championship · Scotland |
| 2010-11-13 | BarrowvAFC WimbledonNational League · England | 2–0 | National League · England |
| 2010-11-13 | PAOKvAEKSuper League · Greece | 2–1 | Super League · Greece |
| 2010-11-13 | AlbacetevVallecanoLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2010-11-13 | OldhamvHuddersfieldLeague One · England | 1–0 | League One · England |
| 2010-11-13 | DunfermlinevRaith RvsChampionship · Scotland | 2–2 | Championship · Scotland |
| 2010-11-13 | StokevLiverpoolPremier League · England | 2–0 | Premier League · England |
| 2010-11-13 | HibernianvMotherwellPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2010-11-13 | TriestinavPortogruaroSerie B · Italy | 0–0 | Serie B · Italy |
| 2010-11-13 | PeterheadvEast FifeLeague One · Scotland | 2–2 | League One · Scotland |
| 2010-11-13 | RangersvAberdeenPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2010-11-13 | Werder BremenvEin FrankfurtBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2010-11-13 | MorecambevLincolnLeague Two · England | 1–2 | League Two · England |
| 2010-11-13 | ArbroathvMontroseLeague Two · Scotland | 4–0 | League Two · Scotland |
| 2010-11-13 | Crystal PalacevCoventryChampionship · England | 2–0 | Championship · England |
| 2010-11-13 | GillinghamvCreweLeague Two · England | 1–3 | League Two · England |
| 2010-11-13 | BarcelonavVillarrealLa Liga · Spain | 3–1 | La Liga · Spain |
| 2010-11-13 | LokerenvSt TruidenPro League · Belgium | 3–0 | Pro League · Belgium |
| 2010-11-13 | BournemouthvWalsallLeague One · England | 3–0 | League One · England |
| 2010-11-13 | BerwickvClydeLeague Two · Scotland | 2–1 | League Two · Scotland |
| 2010-11-13 | HistonvKidderminsterNational League · England | 0–1 | National League · England |
| 2010-11-13 | BordeauxvNancyLigue 1 · France | 2–1 | Ligue 1 · France |
| 2010-11-13 | Sheffield WedsvRochdaleLeague One · England | 2–0 | League One · England |
| 2010-11-13 | Forest GreenvMansfieldNational League · England | 2–1 | National League · England |
| 2010-11-13 | TottenhamvBlackburnPremier League · England | 4–2 | Premier League · England |
| 2010-11-13 | HuescavTenerifeLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |