| 2022-02-25 | MilanvUdineseSerie A · Italy | 1–1 | Serie A · Italy |
| 2022-02-25 | Edinburgh CityvCowdenbeathLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2022-02-25 | Beerschot VAvCharleroiPro League · Belgium | 2–3 | Pro League · Belgium |
| 2022-02-25 | HuracanvVelez SarsfieldCopa De La Liga Profesional · Argentina | 2–0 | Copa De La Liga Profesional · Argentina |
| 2022-02-25 | VejlevAarhusSuperliga · Denmark | 3–2 | Superliga · Denmark |
| 2022-02-25 | SouthamptonvNorwichPremier League · England | 2–0 | Premier League · England |
| 2022-02-25 | AlmeriavFuenlabradaLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2022-02-25 | UTA AradvAcademica ClinceniSuperliga · Romania | 2–0 | Superliga · Romania |
| 2022-02-25 | DroghedavShelbournePremier Division · Ireland | 0–2 | Premier Division · Ireland |
| 2022-02-25 | QueretarovTolucaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2022-02-25 | HannovervHolstein Kiel2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2022-02-25 | Ad. DemirsporvAntalyasporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2022-02-25 | GenoavInterSerie A · Italy | 0–0 | Serie A · Italy |
| 2022-02-25 | HamiltonvInverness CChampionship · Scotland | 1–1 | Championship · Scotland |
| 2022-02-25 | MontpelliervRennesLigue 1 · France | 2–4 | Ligue 1 · France |
| 2022-02-25 | UC DublinvFinn HarpsPremier Division · Ireland | 0–0 | Premier Division · Ireland |
| 2022-02-25 | BohemiansvDundalkPremier Division · Ireland | 2–2 | Premier Division · Ireland |
| 2022-02-25 | Univ. CraiovavChindia TargovisteSuperliga · Romania | 1–0 | Superliga · Romania |
| 2022-02-25 | HoffenheimvStuttgartBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2022-02-25 | Defensa y JusticiavGimnasia L.P.Copa De La Liga Profesional · Argentina | 3–2 | Copa De La Liga Profesional · Argentina |
| 2022-02-25 | Derry CityvShamrock RoversPremier Division · Ireland | 2–1 | Premier Division · Ireland |
| 2022-02-25 | BelenensesvPacos FerreiraPrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2022-02-25 | LevantevElcheLa Liga · Spain | 3–0 | La Liga · Spain |
| 2022-02-25 | LegiavWislaEkstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2022-02-24 | ArsenalvWolvesPremier League · England | 2–1 | Premier League · England |
| 2022-02-23 | LeccevCittadellaSerie B · Italy | 1–2 | Serie B · Italy |
| 2022-02-23 | DerbyvMillwallChampionship · England | 1–2 | Championship · England |
| 2022-02-23 | ArisvAtromitosSuper League · Greece | 3–0 | Super League · Greece |
| 2022-02-23 | HuddersfieldvCardiffChampionship · England | 2–1 | Championship · England |
| 2022-02-23 | CrotonevCosenzaSerie B · Italy | 3–3 | Serie B · Italy |
| 2022-02-23 | WatfordvCrystal PalacePremier League · England | 1–4 | Premier League · England |
| 2022-02-23 | Urawa RedsvVissel KobeJ1 League · Japan | 2–2 | J1 League · Japan |
| 2022-02-23 | Racing ClubvArgentinos JrsCopa De La Liga Profesional · Argentina | 3–0 | Copa De La Liga Profesional · Argentina |
| 2022-02-23 | Sheffield UnitedvBlackburnChampionship · England | 1–0 | Championship · England |
| 2022-02-23 | StokevLutonChampionship · England | 1–2 | Championship · England |
| 2022-02-23 | GaziantepvYeni MalatyasporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2022-02-23 | BurnleyvTottenhamPremier League · England | 1–0 | Premier League · England |
| 2022-02-23 | FrosinonevRegginaSerie B · Italy | 3–0 | Serie B · Italy |
| 2022-02-23 | LiverpoolvLeedsPremier League · England | 6–0 | Premier League · England |
| 2022-02-23 | Central CordobavColon Santa FECopa De La Liga Profesional · Argentina | 0–2 | Copa De La Liga Profesional · Argentina |
| 2022-02-23 | BresciavAscoliSerie B · Italy | 2–0 | Serie B · Italy |
| 2022-02-23 | GentvSeraingPro League · Belgium | 4–0 | Pro League · Belgium |
| 2022-02-23 | Yokohama F. MarinosvKawasaki FrontaleJ1 League · Japan | 4–2 | J1 League · Japan |
| 2022-02-23 | LamiavAsteras TripolisSuper League · Greece | 0–2 | Super League · Greece |
| 2022-02-23 | IonikosvApollonSuper League · Greece | 4–0 | Super League · Greece |
| 2022-02-23 | FulhamvPeterboroChampionship · England | 2–1 | Championship · England |
| 2022-02-23 | BeneventovComoSerie B · Italy | 5–0 | Serie B · Italy |
| 2022-02-23 | QPRvBlackpoolChampionship · England | 2–1 | Championship · England |
| 2022-02-22 | Leyton OrientvBristol RvsLeague Two · England | 0–2 | League Two · England |
| 2022-02-22 | SwindonvWalsallLeague Two · England | 5–0 | League Two · England |