| 2022-02-26 | St MirrenvHeartsPremiership · Scotland | 0–2 | Premiership · Scotland |
| 2022-02-26 | StranraervAlbion RvsLeague Two · Scotland | 0–0 | League Two · Scotland |
| 2022-02-26 | AyrvQueen of SthChampionship · Scotland | 0–1 | Championship · Scotland |
| 2022-02-26 | Cerezo OsakavKyotoJ1 League · Japan | 1–1 | J1 League · Japan |
| 2022-02-26 | MillwallvSheffield UnitedChampionship · England | 1–0 | Championship · England |
| 2022-02-26 | Ath MadridvCeltaLa Liga · Spain | 2–0 | La Liga · Spain |
| 2022-02-26 | GuingampvNiortLigue 2 · France | 1–0 | Ligue 2 · France |
| 2022-02-26 | Queens ParkvMontroseLeague One · Scotland | 0–1 | League One · Scotland |
| 2022-02-26 | Kashima AntlersvKawasaki FrontaleJ1 League · Japan | 0–2 | J1 League · Japan |
| 2022-02-26 | DundeevLivingstonPremiership · Scotland | 0–4 | Premiership · Scotland |
| 2022-02-26 | PeterborovHullChampionship · England | 0–3 | Championship · England |
| 2022-02-26 | LutonvDerbyChampionship · England | 1–0 | Championship · England |
| 2022-02-26 | ValenciennesvPau FCLigue 2 · France | 1–0 | Ligue 2 · France |
| 2022-02-26 | Kelty HeartsvAnnan AthleticLeague Two · Scotland | 3–1 | League Two · Scotland |
| 2022-02-26 | Kings LynnvMaidenheadNational League · England | 1–4 | National League · England |
| 2022-02-26 | BirminghamvHuddersfieldChampionship · England | 0–2 | Championship · England |
| 2022-02-26 | AccringtonvWycombeLeague One · England | 3–2 | League One · England |
| 2022-02-26 | Airdrie UtdvClydeLeague One · Scotland | 1–1 | League One · Scotland |
| 2022-02-26 | Vissel KobevAvispa FukuokaJ1 League · Japan | 0–0 | J1 League · Japan |
| 2022-02-26 | MirandesvTenerifeLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2022-02-26 | Club TijuanavAtlasLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2022-02-26 | SouthendvSolihullNational League · England | 1–1 | National League · England |
| 2022-02-26 | OxfordvCambridgeLeague One · England | 4–2 | League One · England |
| 2022-02-26 | MorecambevIpswichLeague One · England | 1–1 | League One · England |
| 2022-02-26 | SalernitanavBolognaSerie A · Italy | 1–1 | Serie A · Italy |
| 2022-02-26 | AuxerrevQuevilly RouenLigue 2 · France | 1–0 | Ligue 2 · France |
| 2022-02-26 | FC DallasvToronto FCMLS · United States | 1–1 | MLS · United States |
| 2022-02-26 | HalifaxvBarnetNational League · England | 1–0 | National League · England |
| 2022-02-26 | OviedovSociedad BLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2022-02-26 | TernanavCremoneseSerie B · Italy | 1–2 | Serie B · Italy |
| 2022-02-26 | Crystal PalacevBurnleyPremier League · England | 1–1 | Premier League · England |
| 2022-02-26 | Ross CountyvSt JohnstonePremiership · Scotland | 3–1 | Premiership · Scotland |
| 2022-02-26 | SivassporvBesiktasSüper Lig · Turkey | 2–3 | Süper Lig · Turkey |
| 2022-02-26 | MallorcavValenciaLa Liga · Spain | 0–1 | La Liga · Spain |
| 2022-02-26 | Colon Santa FEvBarracas CentralCopa De La Liga Profesional · Argentina | 2–1 | Copa De La Liga Profesional · Argentina |
| 2022-02-26 | Bristol RvsvExeterLeague Two · England | 1–1 | League Two · England |
| 2022-02-26 | FalkirkvEast FifeLeague One · Scotland | 3–1 | League One · Scotland |
| 2022-02-26 | Union BerlinvMainzBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2022-02-26 | Boreham WoodvEastleighNational League · England | 1–0 | National League · England |
| 2022-02-26 | SuttonvScunthorpeLeague Two · England | 4–1 | League Two · England |
| 2022-02-26 | CosenzavAlessandriaSerie B · Italy | 2–1 | Serie B · Italy |
| 2022-02-26 | PlymouthvRotherhamLeague One · England | 0–1 | League One · England |
| 2022-02-26 | PlatensevBanfieldCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2022-02-26 | CambuurvFor SittardEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2022-02-25 | PaderbornvErzgebirge Aue2. Bundesliga · Germany | 3–3 | 2. Bundesliga · Germany |
| 2022-02-25 | St. PatricksvSligo RoversPremier Division · Ireland | 1–2 | Premier Division · Ireland |
| 2022-02-25 | RakowvWisla PlockEkstraklasa · Poland | 2–0 | Ekstraklasa · Poland |
| 2022-02-25 | WaalwijkvTwenteEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2022-02-25 | PachucavMazatlan FCLiga MX · Mexico | 3–1 | Liga MX · Mexico |
| 2022-02-25 | TrabzonsporvKayserisporSüper Lig · Turkey | 3–2 | Süper Lig · Turkey |