| 2022-02-26 | Hokkaido Consadole SapporovSanfrecce HiroshimaJ1 League · Japan | 1–1 | J1 League · Japan |
| 2022-02-26 | LincolnvGillinghamLeague One · England | 0–2 | League One · England |
| 2022-02-26 | Crawley TownvForest GreenLeague Two · England | 2–1 | League Two · England |
| 2022-02-26 | Dover AthleticvGrimsbyNational League · England | 1–3 | National League · England |
| 2022-02-26 | ParmavSpalSerie B · Italy | 4–0 | Serie B · Italy |
| 2022-02-26 | Pari NNvUralPremier League · Russia | 1–0 | Premier League · Russia |
| 2022-02-26 | Austin FCvFC CincinnatiMLS · United States | 5–0 | MLS · United States |
| 2022-02-26 | San Jose EarthquakesvNew York Red BullsMLS · United States | 1–3 | MLS · United States |
| 2022-02-26 | Urawa RedsvGamba OsakaJ1 League · Japan | 0–1 | J1 League · Japan |
| 2022-02-26 | KarlsruhevSchalke 042. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2022-02-26 | AltachvAdmiraBundesliga · Austria | 0–2 | Bundesliga · Austria |
| 2022-02-26 | IngolstadtvSt Pauli2. Bundesliga · Germany | 1–3 | 2. Bundesliga · Germany |
| 2022-02-26 | Oud-Heverlee LeuvenvAnderlechtPro League · Belgium | 0–0 | Pro League · Belgium |
| 2022-02-26 | Columbus CrewvVancouver WhitecapsMLS · United States | 4–0 | MLS · United States |
| 2022-02-26 | OostendevSt TruidenPro League · Belgium | 0–0 | Pro League · Belgium |
| 2022-02-26 | WealdstonevTorquayNational League · England | 1–1 | National League · England |
| 2022-02-26 | AFC WimbledonvDoncasterLeague One · England | 2–2 | League One · England |
| 2022-02-26 | Port ValevStevenageLeague Two · England | 2–0 | League Two · England |
| 2022-02-26 | Philadelphia UnionvMinnesota UnitedMLS · United States | 1–1 | MLS · United States |
| 2022-02-26 | Newport CountyvTranmereLeague Two · England | 4–2 | League Two · England |
| 2022-02-26 | MonterreyvAtl. San LuisLiga MX · Mexico | 0–2 | Liga MX · Mexico |
| 2022-02-26 | PeterheadvDumbartonLeague One · Scotland | 4–3 | League One · Scotland |
| 2022-02-26 | ComovBresciaSerie B · Italy | 1–1 | Serie B · Italy |
| 2022-02-26 | Paris SGvSt EtienneLigue 1 · France | 3–1 | Ligue 1 · France |
| 2022-02-26 | Man UnitedvWatfordPremier League · England | 0–0 | Premier League · England |
| 2022-02-26 | IbizavHuescaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2022-02-26 | HeraclesvZwolleEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2022-02-26 | KhimkivDynamo MoscowPremier League · Russia | 0–3 | Premier League · Russia |
| 2022-02-26 | BrentfordvNewcastlePremier League · England | 0–2 | Premier League · England |
| 2022-02-26 | CardiffvFulhamChampionship · England | 0–1 | Championship · England |
| 2022-02-26 | Ein FrankfurtvBayern MunichBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2022-02-26 | FamalicaovTondelaPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2022-02-26 | Young BoysvSionSuper League · Switzerland | 3–1 | Super League · Switzerland |
| 2022-02-26 | Rosario CentralvGodoy CruzCopa De La Liga Profesional · Argentina | 1–2 | Copa De La Liga Profesional · Argentina |
| 2022-02-26 | LeedsvTottenhamPremier League · England | 0–4 | Premier League · England |
| 2022-02-26 | DresdenvDarmstadt2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2022-02-26 | BrightonvAston VillaPremier League · England | 0–2 | Premier League · England |
| 2022-02-26 | PortsmouthvFleetwood TownLeague One · England | 3–3 | League One · England |
| 2022-02-26 | DC UnitedvCharlotteMLS · United States | 3–0 | MLS · United States |
| 2022-02-26 | AltrinchamvDag and RedNational League · England | 3–0 | National League · England |
| 2022-02-26 | AlloavCove RangersLeague One · Scotland | 2–2 | League One · Scotland |
| 2022-02-26 | LecznavStal MielecEkstraklasa · Poland | 2–0 | Ekstraklasa · Poland |
| 2022-02-26 | ChesterfieldvYeovilNational League · England | 1–0 | National League · England |
| 2022-02-26 | MechelenvCercle BruggePro League · Belgium | 2–2 | Pro League · Belgium |
| 2022-02-26 | BlackpoolvReadingChampionship · England | 4–1 | Championship · England |
| 2022-02-26 | WokingvNotts CountyNational League · England | 0–2 | National League · England |
| 2022-02-26 | Milton Keynes DonsvBoltonLeague One · England | 2–0 | League One · England |
| 2022-02-26 | CheltenhamvCreweLeague One · England | 1–2 | League One · England |
| 2022-02-26 | DunfermlinevKilmarnockChampionship · Scotland | 0–0 | Championship · Scotland |
| 2022-02-26 | ElginvStirlingLeague Two · Scotland | 3–1 | League Two · Scotland |