| 2016-02-27 | ZurichvYoung BoysSuper League · Switzerland | 0–1 | Super League · Switzerland |
| 2016-02-27 | CordobavOsasunaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2016-02-27 | CardiffvPrestonChampionship · England | 2–1 | Championship · England |
| 2016-02-27 | WolfsburgvBayern MunichBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2016-02-27 | Queens ParkvEast FifeLeague Two · Scotland | 3–0 | League Two · Scotland |
| 2016-02-27 | PanetolikosvXanthiSuper League · Greece | 2–2 | Super League · Greece |
| 2016-02-27 | TrabzonsporvOsmanlisporSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2016-02-27 | PSV EindhovenvDen HaagEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2016-02-27 | HamburgvIngolstadtBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2016-02-27 | ElginvEast StirlingLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2016-02-27 | TroyesvLorientLigue 1 · France | 0–1 | Ligue 1 · France |
| 2016-02-27 | Oud-Heverlee LeuvenvOostendePro League · Belgium | 4–1 | Pro League · Belgium |
| 2016-02-27 | FalkirkvQueen of SthChampionship · Scotland | 3–1 | Championship · Scotland |
| 2016-02-27 | U CraiovavCFR ClujSuperliga · Romania | 0–1 | Superliga · Romania |
| 2016-02-27 | ReimsvBordeauxLigue 1 · France | 4–1 | Ligue 1 · France |
| 2016-02-27 | VitessevWillem IIEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2016-02-27 | ScunthorpevOldhamLeague One · England | 1–1 | League One · England |
| 2016-02-27 | WislavPodbeskidzieEkstraklasa · Poland | 1–2 | Ekstraklasa · Poland |
| 2016-02-27 | Munich 1860vFortuna Dusseldorf2. Bundesliga · Germany | 3–2 | 2. Bundesliga · Germany |
| 2016-02-27 | StevenagevExeterLeague Two · England | 0–2 | League Two · England |
| 2016-02-27 | BlackpoolvBradfordLeague One · England | 0–1 | League One · England |
| 2016-02-27 | GuiseleyvBraintree TownNational League · England | 1–1 | National League · England |
| 2016-02-27 | ColchestervShrewsburyLeague One · England | 0–0 | League One · England |
| 2016-02-27 | Lechia GdanskvPiast GliwiceEkstraklasa · Poland | 3–1 | Ekstraklasa · Poland |
| 2016-02-27 | Sarmiento JuninvQuilmesLiga Profesional · Argentina | 2–2 | Liga Profesional · Argentina |
| 2016-02-27 | West HamvSunderlandPremier League · England | 1–0 | Premier League · England |
| 2016-02-27 | DundeevInverness CPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2016-02-27 | Virtus LancianovBariSerie B · Italy | 1–0 | Serie B · Italy |
| 2016-02-27 | Annan AthleticvStirlingLeague Two · Scotland | 2–2 | League Two · Scotland |
| 2016-02-27 | AccringtonvBarnetLeague Two · England | 2–2 | League Two · England |
| 2016-02-27 | HuracanvSan LorenzoLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2016-02-27 | SionvLuzernSuper League · Switzerland | 3–1 | Super League · Switzerland |
| 2016-02-27 | PortsmouthvCambridgeLeague Two · England | 2–1 | League Two · England |
| 2016-02-27 | AlloavLivingstonChampionship · Scotland | 1–3 | Championship · Scotland |
| 2016-02-27 | HuddersfieldvIpswichChampionship · England | 0–1 | Championship · England |
| 2016-02-27 | BanfieldvGodoy CruzLiga Profesional · Argentina | 2–3 | Liga Profesional · Argentina |
| 2016-02-27 | MotherwellvPartickPremiership · Scotland | 3–1 | Premiership · Scotland |
| 2016-02-27 | Sp GijonvEspanolLa Liga · Spain | 2–4 | La Liga · Spain |
| 2016-02-27 | CambuurvZwolleEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2016-02-27 | Estudiantes L.P.vArgentinos JrsLiga Profesional · Argentina | 4–1 | Liga Profesional · Argentina |
| 2016-02-27 | WiganvBuryLeague One · England | 3–0 | League One · England |
| 2016-02-27 | AroucavSp BragaPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2016-02-27 | BetisvVallecanoLa Liga · Spain | 2–2 | La Liga · Spain |
| 2016-02-27 | WolvesvDerbyChampionship · England | 2–1 | Championship · England |
| 2016-02-26 | DijonvToursLigue 2 · France | 3–0 | Ligue 2 · France |
| 2016-02-26 | NiortvLe HavreLigue 2 · France | 0–0 | Ligue 2 · France |
| 2016-02-26 | BuyuksehyrvKayserisporSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2016-02-26 | MetzvBrestLigue 2 · France | 2–2 | Ligue 2 · France |
| 2016-02-26 | NicevBastiaLigue 1 · France | 0–2 | Ligue 1 · France |
| 2016-02-26 | ExcelsiorvNijmegenEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |