| 2022-02-26 | AmiensvNimesLigue 2 · France | 3–0 | Ligue 2 · France |
| 2022-02-26 | CaenvBastiaLigue 2 · France | 2–1 | Ligue 2 · France |
| 2022-02-26 | AroucavMoreirensePrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2022-02-26 | LuganovServetteSuper League · Switzerland | 2–0 | Super League · Switzerland |
| 2022-02-26 | AberdeenvDundee UnitedPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2022-02-26 | BuyuksehyrvKaragumrukSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2022-02-26 | AldosivivCentral CordobaCopa De La Liga Profesional · Argentina | 0–0 | Copa De La Liga Profesional · Argentina |
| 2022-02-26 | SassuolovFiorentinaSerie A · Italy | 2–1 | Serie A · Italy |
| 2022-02-26 | PerugiavBeneventoSerie B · Italy | 0–1 | Serie B · Italy |
| 2022-02-26 | BarrowvHarrogateLeague Two · England | 0–0 | League Two · England |
| 2022-02-26 | VallecanovReal MadridLa Liga · Spain | 0–1 | La Liga · Spain |
| 2022-02-26 | WiganvSunderlandLeague One · England | 0–3 | League One · England |
| 2022-02-26 | JuarezvTigres UANLLiga MX · Mexico | 2–3 | Liga MX · Mexico |
| 2022-02-26 | Hansa RostockvNurnberg2. Bundesliga · Germany | 0–2 | 2. Bundesliga · Germany |
| 2022-02-26 | DunkerquevDijonLigue 2 · France | 2–1 | Ligue 2 · France |
| 2022-02-26 | StrasbourgvNiceLigue 1 · France | 0–0 | Ligue 1 · France |
| 2022-02-26 | Leyton OrientvCarlisleLeague Two · England | 0–1 | League Two · England |
| 2022-02-26 | Asteras TripolisvArisSuper League · Greece | 0–2 | Super League · Greece |
| 2022-02-26 | BournemouthvStokeChampionship · England | 2–1 | Championship · England |
| 2022-02-26 | Sheffield WedsvCharltonLeague One · England | 2–0 | League One · England |
| 2022-02-26 | Spartak MoscowvCSKA MoscowPremier League · Russia | 0–2 | Premier League · Russia |
| 2022-02-26 | Las PalmasvLugoLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |
| 2022-02-26 | FreiburgvHerthaBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2022-02-26 | EvertonvMan CityPremier League · England | 0–1 | Premier League · England |
| 2022-02-26 | CoventryvPrestonChampionship · England | 1–1 | Championship · England |
| 2022-02-26 | Nott'm ForestvBristol CityChampionship · England | 2–0 | Championship · England |
| 2022-02-26 | BarnsleyvMiddlesbroughChampionship · England | 3–2 | Championship · England |
| 2022-02-26 | Pogon SzczecinvLech PoznanEkstraklasa · Poland | 0–3 | Ekstraklasa · Poland |
| 2022-02-26 | BlackburnvQPRChampionship · England | 1–0 | Championship · England |
| 2022-02-26 | Piast GliwicevGornik Z.Ekstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2022-02-26 | Sepsi Sf. GheorghevCFR ClujSuperliga · Romania | 0–2 | Superliga · Romania |
| 2022-02-26 | FC Rapid BucurestivDin. BucurestiSuperliga · Romania | 1–1 | Superliga · Romania |
| 2022-02-26 | PanetolikosvVolos NFCSuper League · Greece | 0–0 | Super League · Greece |
| 2022-02-26 | StockportvWeymouthNational League · England | 1–0 | National League · England |
| 2022-02-26 | RochdalevNorthamptonLeague Two · England | 1–0 | League Two · England |
| 2022-02-26 | Raith RvsvPartickChampionship · Scotland | 0–0 | Championship · Scotland |
| 2022-02-26 | Los Angeles FCvColorado RapidsMLS · United States | 3–0 | MLS · United States |
| 2022-02-26 | St. GilloisevEupenPro League · Belgium | 0–0 | Pro League · Belgium |
| 2022-02-26 | M'gladbachvWolfsburgBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2022-02-26 | BradfordvMansfieldLeague Two · England | 0–2 | League Two · England |
| 2022-02-26 | Paris FCvSochauxLigue 2 · France | 3–1 | Ligue 2 · France |
| 2022-02-26 | GetafevAlavesLa Liga · Spain | 2–2 | La Liga · Spain |
| 2022-02-26 | AjacciovRodezLigue 2 · France | 2–1 | Ligue 2 · France |
| 2022-02-26 | LeverkusenvBielefeldBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2022-02-26 | StenhousemuirvForfarLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2022-02-26 | SwindonvSalfordLeague Two · England | 1–2 | League Two · England |
| 2022-02-26 | WalsallvHartlepoolLeague Two · England | 3–1 | League Two · England |
| 2022-02-26 | GroningenvWillem IIEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2022-02-26 | VicenzavPordenoneSerie B · Italy | 1–0 | Serie B · Italy |
| 2022-02-26 | ColchestervOldhamLeague Two · England | 1–1 | League Two · England |