| 2021-03-14 | PSV EindhovenvFeyenoordEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-03-14 | Lech PoznanvPiast GliwiceEkstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2021-03-14 | KarlsruhevBraunschweig2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2021-03-14 | LensvMetzLigue 1 · France | 2–2 | Ligue 1 · France |
| 2021-03-14 | GuimaraesvGil VicentePrimeira Liga · Portugal | 2–4 | Primeira Liga · Portugal |
| 2021-03-14 | UtrechtvVitesseEredivisie · Netherlands | 1–3 | Eredivisie · Netherlands |
| 2021-03-14 | Oita TrinitavFC TokyoJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-03-14 | NimesvMontpellierLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-03-14 | Wolfsberger ACvTirolBundesliga · Austria | 3–5 | Bundesliga · Austria |
| 2021-03-14 | FC CopenhagenvMidtjyllandSuperliga · Denmark | 0–0 | Superliga · Denmark |
| 2021-03-14 | PanathinaikosvPAOKSuper League · Greece | 2–1 | Super League · Greece |
| 2021-03-14 | Tigres UANLvMazatlan FCLiga MX · Mexico | 1–2 | Liga MX · Mexico |
| 2021-03-14 | VVV VenlovFor SittardEredivisie · Netherlands | 1–3 | Eredivisie · Netherlands |
| 2021-03-14 | Volos NFCvAEKSuper League · Greece | 1–0 | Super League · Greece |
| 2021-03-14 | RennesvStrasbourgLigue 1 · France | 1–0 | Ligue 1 · France |
| 2021-03-14 | PortovPacos FerreiraPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2021-03-14 | Erzurum BBvTrabzonsporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2021-03-14 | SouthamptonvBrightonPremier League · England | 1–2 | Premier League · England |
| 2021-03-14 | LeicestervSheffield UnitedPremier League · England | 5–0 | Premier League · England |
| 2021-03-14 | TolucavPachucaLiga MX · Mexico | 0–2 | Liga MX · Mexico |
| 2021-03-14 | Man UnitedvWest HamPremier League · England | 1–0 | Premier League · England |
| 2021-03-14 | Boca JuniorsvRiver PlateCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2021-03-14 | FenerbahcevGenclerbirligiSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2021-03-14 | CagliarivJuventusSerie A · Italy | 1–3 | Serie A · Italy |
| 2021-03-14 | St. PoltenvAltachBundesliga · Austria | 0–1 | Bundesliga · Austria |
| 2021-03-14 | LorientvNiceLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-03-14 | NurnbergvOsnabruck2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-03-14 | TorinovInterSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-03-14 | Yokohama F. MarinosvUrawa RedsJ1 League · Japan | 3–0 | J1 League · Japan |
| 2021-03-14 | ZwollevAjaxEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2021-03-14 | Lokomotiv MoscowvSochiPremier League · Russia | 3–1 | Premier League · Russia |
| 2021-03-14 | ApollonvPanetolikosSuper League · Greece | 1–0 | Super League · Greece |
| 2021-03-14 | Sturm GrazvAustria ViennaBundesliga · Austria | 2–1 | Bundesliga · Austria |
| 2021-03-14 | UfavRubin KazanPremier League · Russia | 0–3 | Premier League · Russia |
| 2021-03-14 | OviedovLeganesLa Liga 2 · Spain | 1–3 | La Liga 2 · Spain |
| 2021-03-14 | CeltavAth BilbaoLa Liga · Spain | 0–0 | La Liga · Spain |
| 2021-03-14 | GaziantepvDenizlisporSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2021-03-14 | LogronesvMalagaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-03-14 | Asteras TripolisvGianninaSuper League · Greece | 0–1 | Super League · Greece |
| 2021-03-14 | AnkaragucuvGoztepSüper Lig · Turkey | 3–0 | Süper Lig · Turkey |
| 2021-03-14 | StuttgartvHoffenheimBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2021-03-14 | Shimizu S-PulsevSagan TosuJ1 League · Japan | 0–0 | J1 League · Japan |
| 2021-03-14 | MilanvNapoliSerie A · Italy | 0–1 | Serie A · Italy |
| 2021-03-14 | GranadavSociedadLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-03-14 | MoreirensevRio AvePrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2021-03-14 | DijonvBordeauxLigue 1 · France | 1–3 | Ligue 1 · France |
| 2021-03-14 | TenerifevAlbaceteLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-03-14 | SionvServetteSuper League · Switzerland | 1–2 | Super League · Switzerland |
| 2021-03-14 | Gornik Z.vZaglebieEkstraklasa · Poland | 2–0 | Ekstraklasa · Poland |
| 2021-03-14 | ArisvOFI CreteSuper League · Greece | 1–0 | Super League · Greece |