| 2022-02-28 | Shamrock RoversvDroghedaPremier Division · Ireland | 3–1 | Premier Division · Ireland |
| 2022-02-28 | Argentinos JrsvSan LorenzoCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2022-02-28 | Sp BragavSanta ClaraPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2022-02-28 | Houston DynamovReal Salt LakeMLS · United States | 0–0 | MLS · United States |
| 2022-02-28 | Seattle SoundersvNashville SCMLS · United States | 0–1 | MLS · United States |
| 2022-02-27 | Orlando CityvCF MontrealMLS · United States | 2–0 | MLS · United States |
| 2022-02-27 | Slask WroclawvZaglebieEkstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2022-02-27 | Sarmiento JuninvUnion de Santa FeCopa De La Liga Profesional · Argentina | 2–1 | Copa De La Liga Profesional · Argentina |
| 2022-02-27 | ZurichvBaselSuper League · Switzerland | 4–2 | Super League · Switzerland |
| 2022-02-27 | AalborgvSilkeborgSuperliga · Denmark | 1–4 | Superliga · Denmark |
| 2022-02-27 | Los Angeles GalaxyvNew York CityMLS · United States | 1–0 | MLS · United States |
| 2022-02-27 | AZ AlkmaarvFeyenoordEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2022-02-27 | BenficavGuimaraesPrimeira Liga · Portugal | 3–0 | Primeira Liga · Portugal |
| 2022-02-27 | UNAM PumasvClub AmericaLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2022-02-27 | GenkvKortrijkPro League · Belgium | 2–0 | Pro League · Belgium |
| 2022-02-27 | TirolvSK RapidBundesliga · Austria | 0–2 | Bundesliga · Austria |
| 2022-02-27 |  MonacovReimsLigue 1 · France | 1–2 | Ligue 1 · France |
| 2022-02-27 | FCSBvFarul ConstantaSuperliga · Romania | 0–2 | Superliga · Romania |
| 2022-02-27 | EibarvBurgosLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2022-02-27 | OdensevMidtjyllandSuperliga · Denmark | 2–2 | Superliga · Denmark |
| 2022-02-27 | Portland TimbersvNew England RevolutionMLS · United States | 2–2 | MLS · United States |
| 2022-02-27 | RangersvMotherwellPremiership · Scotland | 2–2 | Premiership · Scotland |
| 2022-02-27 | FC ArgesvFC VoluntariSuperliga · Romania | 0–0 | Superliga · Romania |
| 2022-02-27 | FC BotosanivMioveniSuperliga · Romania | 0–0 | Superliga · Romania |
| 2022-02-27 | TorinovCagliariSerie A · Italy | 1–2 | Serie A · Italy |
| 2022-02-27 | HibernianvCelticPremiership · Scotland | 0–0 | Premiership · Scotland |
| 2022-02-27 | Atlanta UtdvSporting Kansas CityMLS · United States | 3–1 | MLS · United States |
| 2022-02-27 | SociedadvOsasunaLa Liga · Spain | 1–0 | La Liga · Spain |
| 2022-02-27 | RegginavPisaSerie B · Italy | 1–0 | Serie B · Italy |
| 2022-02-27 | BrestvLorientLigue 1 · France | 0–1 | Ligue 1 · France |
| 2022-02-27 | A. KlagenfurtvRiedBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2022-02-27 | VizelavPortimonensePrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2022-02-27 | AlanyasporvKonyasporSüper Lig · Turkey | 5–1 | Süper Lig · Turkey |
| 2022-02-27 | River PlatevRacing ClubCopa De La Liga Profesional · Argentina | 2–2 | Copa De La Liga Profesional · Argentina |
| 2022-02-27 | AugsburgvDortmundBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-02-27 | LausannevLuzernSuper League · Switzerland | 1–2 | Super League · Switzerland |
| 2022-02-27 | MonzavLecceSerie B · Italy | 0–1 | Serie B · Italy |
| 2022-02-27 | Sturm GrazvHartbergBundesliga · Austria | 3–0 | Bundesliga · Austria |
| 2022-02-27 | AltayvGaziantepSüper Lig · Turkey | 3–2 | Süper Lig · Turkey |
| 2022-02-27 | Go Ahead EaglesvAjaxEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2022-02-27 | AscolivCrotoneSerie B · Italy | 2–1 | Serie B · Italy |
| 2022-02-27 | HataysporvYeni MalatyasporSüper Lig · Turkey | 5–2 | Süper Lig · Turkey |
| 2022-02-27 | VeronavVeneziaSerie A · Italy | 3–1 | Serie A · Italy |
| 2022-02-27 | HamburgvWerder Bremen2. Bundesliga · Germany | 2–3 | 2. Bundesliga · Germany |
| 2022-02-27 | VillarrealvEspanolLa Liga · Spain | 5–1 | La Liga · Spain |
| 2022-02-27 | Kashiwa ReysolvYokohama F. MarinosJ1 League · Japan | 3–1 | J1 League · Japan |
| 2022-02-27 | LyonvLilleLigue 1 · France | 0–1 | Ligue 1 · France |
| 2022-02-27 | LeganesvGironaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2022-02-27 | Sparta RotterdamvPSV EindhovenEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2022-02-27 | GiresunsporvGoztepSüper Lig · Turkey | 3–1 | Süper Lig · Turkey |