| 2022-03-05 | Crawley TownvScunthorpeLeague Two · England | 0–0 | League Two · England |
| 2022-03-05 | Pau FCvAmiensLigue 2 · France | 2–1 | Ligue 2 · France |
| 2022-03-05 | PortimonensevBenficaPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2022-03-05 | TenerifevValladolidLa Liga 2 · Spain | 1–4 | La Liga 2 · Spain |
| 2022-03-05 | StuttgartvM'gladbachBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2022-03-05 | FeyenoordvGroningenEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2022-03-05 | KortrijkvSt. GilloisePro League · Belgium | 2–3 | Pro League · Belgium |
| 2022-03-05 | ClydevFalkirkLeague One · Scotland | 1–1 | League One · Scotland |
| 2022-03-05 | DijonvCaenLigue 2 · France | 1–0 | Ligue 2 · France |
| 2022-03-05 | ParmavRegginaSerie B · Italy | 1–1 | Serie B · Italy |
| 2022-03-05 | ReadingvMillwallChampionship · England | 0–1 | Championship · England |
| 2022-03-05 | CambridgevShrewsburyLeague One · England | 0–0 | League One · England |
| 2022-03-05 | BurnleyvChelseaPremier League · England | 0–4 | Premier League · England |
| 2022-03-05 | SuttonvRochdaleLeague Two · England | 3–0 | League Two · England |
| 2022-03-05 | PatronatovSarmiento JuninCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2022-03-05 | LeicestervLeedsPremier League · England | 1–0 | Premier League · England |
| 2022-03-05 | EastleighvWealdstoneNational League · England | 4–1 | National League · England |
| 2022-03-05 | ForfarvElginLeague Two · Scotland | 0–0 | League Two · Scotland |
| 2022-03-05 | UTA AradvMioveniSuperliga · Romania | 2–1 | Superliga · Romania |
| 2022-03-05 | HarrogatevHartlepoolLeague Two · England | 1–2 | League Two · England |
| 2022-03-05 | Sp LisbonvAroucaPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2022-03-05 | SalzburgvAltachBundesliga · Austria | 4–0 | Bundesliga · Austria |
| 2022-03-05 | Lechia GdanskvWislaEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2022-03-05 | HerthavEin FrankfurtBundesliga · Germany | 1–4 | Bundesliga · Germany |
| 2022-03-05 | MiddlesbroughvLutonChampionship · England | 2–1 | Championship · England |
| 2022-03-05 | Schalke 04vHansa Rostock2. Bundesliga · Germany | 3–4 | 2. Bundesliga · Germany |
| 2022-03-05 | NimesvParis FCLigue 2 · France | 1–1 | Ligue 2 · France |
| 2022-03-05 | Go Ahead EaglesvUtrechtEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2022-03-05 | Annan AthleticvStranraerLeague Two · Scotland | 4–1 | League Two · Scotland |
| 2022-03-05 | Termalica B-B.vWarta PoznanEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2022-03-05 | ChesterfieldvSouthendNational League · England | 2–2 | National League · England |
| 2022-03-05 | LincolnvSheffield WedsLeague One · England | 3–1 | League One · England |
| 2022-03-05 | GoztepvKasimpasaSüper Lig · Turkey | 2–3 | Süper Lig · Turkey |
| 2022-03-05 | PortsmouthvAccringtonLeague One · England | 4–0 | League One · England |
| 2022-03-05 | NiortvAjaccioLigue 2 · France | 0–1 | Ligue 2 · France |
| 2022-03-05 | ArbroathvDunfermlineChampionship · Scotland | 1–0 | Championship · Scotland |
| 2022-03-05 | FC CincinnativDC UnitedMLS · United States | 0–1 | MLS · United States |
| 2022-03-05 | Dundee UnitedvHeartsPremiership · Scotland | 2–2 | Premiership · Scotland |
| 2022-03-05 | FuenlabradavBurgosLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2022-03-04 | Gil VicentevEstorilPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2022-03-04 | HuddersfieldvPeterboroChampionship · England | 3–0 | Championship · England |
| 2022-03-04 | Finn HarpsvBohemiansPremier Division · Ireland | 1–1 | Premier Division · Ireland |
| 2022-03-04 | St. PatricksvShamrock RoversPremier Division · Ireland | 1–0 | Premier Division · Ireland |
| 2022-03-04 | MidtjyllandvViborgSuperliga · Denmark | 3–1 | Superliga · Denmark |
| 2022-03-04 | St TruidenvMechelenPro League · Belgium | 1–1 | Pro League · Belgium |
| 2022-03-04 | ShelbournevDerry CityPremier Division · Ireland | 0–1 | Premier Division · Ireland |
| 2022-03-04 | AlavesvSevillaLa Liga · Spain | 0–0 | La Liga · Spain |
| 2022-03-04 | Stal MielecvJagielloniaEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2022-03-04 | LorientvLyonLigue 1 · France | 1–4 | Ligue 1 · France |
| 2022-03-04 | IntervSalernitanaSerie A · Italy | 5–0 | Serie A · Italy |