| 2022-03-05 | CremonesevBresciaSerie B · Italy | 2–1 | Serie B · Italy |
| 2022-03-05 | Albion RvsvEdinburgh CityLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2022-03-05 | CharltonvSunderlandLeague One · England | 0–0 | League One · England |
| 2022-03-05 | RomavAtalantaSerie A · Italy | 1–0 | Serie A · Italy |
| 2022-03-05 | LausannevZurichSuper League · Switzerland | 0–2 | Super League · Switzerland |
| 2022-03-05 | BradfordvSwindonLeague Two · England | 1–2 | League Two · England |
| 2022-03-05 | San LorenzovRiver PlateCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2022-03-05 | WeymouthvHalifaxNational League · England | 0–2 | National League · England |
| 2022-03-05 | ValenciavGranadaLa Liga · Spain | 3–1 | La Liga · Spain |
| 2022-03-05 | LensvBrestLigue 1 · France | 0–1 | Ligue 1 · France |
| 2022-03-05 | Notts CountyvYeovilNational League · England | 1–1 | National League · England |
| 2022-03-05 | NurnbergvHamburg2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2022-03-05 | CrewevWycombeLeague One · England | 1–3 | League One · England |
| 2022-03-05 | AlloavAirdrie UtdLeague One · Scotland | 0–2 | League One · Scotland |
| 2022-03-05 | KilmarnockvHamiltonChampionship · Scotland | 2–0 | Championship · Scotland |
| 2022-03-05 | SandhausenvHannover2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2022-03-05 | JuarezvClub LeonLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2022-03-05 | NancyvGrenobleLigue 2 · France | 0–1 | Ligue 2 · France |
| 2022-03-05 | RizesporvGiresunsporSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2022-03-05 | Colorado RapidsvAtlanta UtdMLS · United States | 3–0 | MLS · United States |
| 2022-03-05 | SolihullvKings LynnNational League · England | 2–2 | National League · England |
| 2022-03-05 | CowdenbeathvKelty HeartsLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2022-03-05 | San Jose EarthquakesvColumbus CrewMLS · United States | 3–3 | MLS · United States |
| 2022-03-05 | BarnetvDover AthleticNational League · England | 6–0 | National League · England |
| 2022-03-05 | BarrowvWalsallLeague Two · England | 1–1 | League Two · England |
| 2022-03-05 | ZaglebievPiast GliwiceEkstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2022-03-05 | Bayern MunichvLeverkusenBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-03-05 | NicevParis SGLigue 1 · France | 1–0 | Ligue 1 · France |
| 2022-03-05 | CSKA MoscowvPari NNPremier League · Russia | 1–0 | Premier League · Russia |
| 2022-03-05 | Newport CountyvBristol RvsLeague Two · England | 1–0 | League Two · England |
| 2022-03-05 | KonyasporvGalatasaraySüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2022-03-05 | Toronto FCvNew York Red BullsMLS · United States | 1–4 | MLS · United States |
| 2022-03-05 | WolvesvCrystal PalacePremier League · England | 0–2 | Premier League · England |
| 2022-03-05 | SwanseavCoventryChampionship · England | 3–1 | Championship · England |
| 2022-03-05 | DumbartonvQueens ParkLeague One · Scotland | 0–3 | League One · Scotland |
| 2022-03-05 | ComovSpalSerie B · Italy | 0–2 | Serie B · Italy |
| 2022-03-05 | CheltenhamvDoncasterLeague One · England | 4–0 | League One · England |
| 2022-03-05 | ColchestervPort ValeLeague Two · England | 1–0 | League Two · England |
| 2022-03-05 | Young BoysvLuzernSuper League · Switzerland | 2–2 | Super League · Switzerland |
| 2022-03-05 | PrestonvBournemouthChampionship · England | 2–1 | Championship · England |
| 2022-03-05 | BastiavValenciennesLigue 2 · France | 1–1 | Ligue 2 · France |
| 2022-03-05 | HibernianvSt JohnstonePremiership · Scotland | 0–0 | Premiership · Scotland |
| 2022-03-05 | DerbyvBarnsleyChampionship · England | 2–0 | Championship · England |
| 2022-03-05 | RotherhamvMilton Keynes DonsLeague One · England | 1–2 | League One · England |
| 2022-03-05 | KyotovIwataJ1 League · Japan | 1–4 | J1 League · Japan |
| 2022-03-05 | EspanolvGetafeLa Liga · Spain | 2–0 | La Liga · Spain |
| 2022-03-05 | RodezvAuxerreLigue 2 · France | 1–3 | Ligue 2 · France |
| 2022-03-05 | HuescavLas PalmasLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2022-03-05 | CF MontrealvPhiladelphia UnionMLS · United States | 1–2 | MLS · United States |
| 2022-03-05 | RangersvAberdeenPremiership · Scotland | 1–0 | Premiership · Scotland |