| 2021-03-20 | PortimonensevPortoPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2021-03-20 | ValladolidvSevillaLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-03-20 | TorquayvKings LynnNational League · England | 1–0 | National League · England |
| 2021-03-20 | LeganesvFuenlabradaLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2021-03-20 | PrestonvLutonChampionship · England | 0–1 | Championship · England |
| 2021-03-20 | BrightonvNewcastlePremier League · England | 3–0 | Premier League · England |
| 2021-03-20 | MetzvRennesLigue 1 · France | 1–3 | Ligue 1 · France |
| 2021-03-20 | ShrewsburyvHullLeague One · England | 1–1 | League One · England |
| 2021-03-20 | PortsmouthvIpswichLeague One · England | 2–1 | League One · England |
| 2021-03-20 | AltrinchamvDag and RedNational League · England | 0–1 | National League · England |
| 2021-03-20 | Mazatlan FCvClub AmericaLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-03-20 | HamiltonvSt MirrenPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2021-03-20 | CrotonevBolognaSerie A · Italy | 2–3 | Serie A · Italy |
| 2021-03-20 | PanetolikosvLamiaSuper League · Greece | 0–3 | Super League · Greece |
| 2021-03-20 | MortonvQueen of SthChampionship · Scotland | 2–1 | Championship · Scotland |
| 2021-03-20 | FeyenoordvFC EmmenEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-03-20 | BarrowvCrawley TownLeague Two · England | 3–2 | League Two · England |
| 2021-03-20 | LongfordvDerry CityPremier Division · Ireland | 2–0 | Premier Division · Ireland |
| 2021-03-20 | NancyvClermontLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-03-20 | Central CordobavEstudiantes L.P.Copa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2021-03-20 | Ath BilbaovEibarLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-03-20 | AmiensvTroyesLigue 2 · France | 3–1 | Ligue 2 · France |
| 2021-03-20 | Poli IasivDin. BucurestiSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-03-20 |  Omanv JordanFriendly | 0–0 | Friendly |
| 2021-03-20 | ApollonvLarisaSuper League · Greece | 0–2 | Super League · Greece |
| 2021-03-20 | Werder BremenvWolfsburgBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2021-03-20 | St JohnstonevRoss CountyPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2021-03-20 | Newport CountyvLeyton OrientLeague Two · England | 0–1 | League Two · England |
| 2021-03-20 | ColchestervPort ValeLeague Two · England | 0–1 | League Two · England |
| 2021-03-20 | Queens ParkvStranraerLeague Two · Scotland | 3–0 | League Two · Scotland |
| 2021-03-20 | Lech PoznanvJagielloniaEkstraklasa · Poland | 2–3 | Ekstraklasa · Poland |
| 2021-03-20 | StirlingvBrechinLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2021-03-20 | BradfordvOldhamLeague Two · England | 0–0 | League Two · England |
| 2021-03-20 | OxfordvBlackpoolLeague One · England | 0–2 | League One · England |
| 2021-03-20 | StevenagevCarlisleLeague Two · England | 3–1 | League Two · England |
| 2021-03-20 | HamburgvHeidenheim2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2021-03-20 | Gimnasia L.P.vAtl. TucumanCopa De La Liga Profesional · Argentina | 2–0 | Copa De La Liga Profesional · Argentina |
| 2021-03-20 | Erzgebirge AuevSandhausen2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2021-03-20 | Atl. San LuisvUNAM PumasLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-03-20 | EspanolvLogronesLa Liga 2 · Spain | 4–0 | La Liga 2 · Spain |
| 2021-03-20 | BoltonvWalsallLeague Two · England | 2–1 | League Two · England |
| 2021-03-20 | AccringtonvWiganLeague One · England | 3–1 | League One · England |
| 2021-03-20 | Paris FCvGrenobleLigue 2 · France | 2–0 | Ligue 2 · France |
| 2021-03-20 | BanfieldvLanusCopa De La Liga Profesional · Argentina | 2–0 | Copa De La Liga Profesional · Argentina |
| 2021-03-20 | CoventryvWycombeChampionship · England | 0–0 | Championship · England |
| 2021-03-20 | HartlepoolvWokingNational League · England | 1–0 | National League · England |
| 2021-03-20 | SabadellvSp GijonLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-03-20 | ReggianavCosenzaSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-03-20 | MillwallvMiddlesbroughChampionship · England | 1–0 | Championship · England |
| 2021-03-20 | DumbartonvForfarLeague One · Scotland | 0–1 | League One · Scotland |