| 2008-11-22 | NavalvSp LisbonPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2008-11-22 | FC KolnvHoffenheimBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2008-11-22 | Dundee UnitedvHamiltonPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2008-11-22 | ChestervAldershotLeague Two · England | 0–1 | League Two · England |
| 2008-11-22 | BurnleyvDoncasterChampionship · England | 0–0 | Championship · England |
| 2008-11-22 | Sheffield WedsvCoventryChampionship · England | 0–1 | Championship · England |
| 2008-11-22 | KidderminstervWrexhamNational League · England | 1–0 | National League · England |
| 2008-11-22 | TwentevHeerenveenEredivisie · Netherlands | 6–0 | Eredivisie · Netherlands |
| 2008-11-22 | Cercle BruggevMechelenPro League · Belgium | 2–1 | Pro League · Belgium |
| 2008-11-22 | SouthendvOldhamLeague One · England | 1–2 | League One · England |
| 2008-11-22 | BergenvClub BruggePro League · Belgium | 1–2 | Pro League · Belgium |
| 2008-11-22 | SalisburyvNorthwichNational League · England | 1–1 | National League · England |
| 2008-11-22 | BresciavVicenzaSerie B · Italy | 2–1 | Serie B · Italy |
| 2008-11-22 | ParmavLivornoSerie B · Italy | 0–0 | Serie B · Italy |
| 2008-11-22 | WolvesvBlackpoolChampionship · England | 2–0 | Championship · England |
| 2008-11-22 | AnkaragucuvFenerbahceSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2008-11-22 | RangersvAberdeenPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2008-11-22 | PeterheadvStirlingLeague One · Scotland | 1–1 | League One · Scotland |
| 2008-11-22 | MontrosevForfarLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2008-11-22 | ValenciennesvSochauxLigue 1 · France | 2–2 | Ligue 1 · France |
| 2008-11-22 | FiorentinavUdineseSerie A · Italy | 4–2 | Serie A · Italy |
| 2008-11-22 | BrightonvHuddersfieldLeague One · England | 0–1 | League One · England |
| 2008-11-22 | VillarrealvValladolidLa Liga · Spain | 0–3 | La Liga · Spain |
| 2008-11-22 | Crystal PalacevBristol CityChampionship · England | 4–2 | Championship · England |
| 2008-11-22 | DunfermlinevMortonChampionship · Scotland | 0–1 | Championship · Scotland |
| 2008-11-22 | Real MadridvRecreativoLa Liga · Spain | 1–0 | La Liga · Spain |
| 2008-11-22 | IntervJuventusSerie A · Italy | 1–0 | Serie A · Italy |
| 2008-11-22 | Paris SGvLyonLigue 1 · France | 1–0 | Ligue 1 · France |
| 2008-11-22 | CarlislevCheltenhamLeague One · England | 1–0 | League One · England |
| 2008-11-22 | PartickvLivingstonChampionship · Scotland | 2–1 | Championship · Scotland |
| 2008-11-22 | BochumvHerthaBundesliga · Germany | 2–3 | Bundesliga · Germany |
| 2008-11-22 | MaritimovSp BragaPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2008-11-22 | PisavCittadellaSerie B · Italy | 0–3 | Serie B · Italy |
| 2008-11-22 | Las PalmasvTenerifeLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2008-11-22 | BielefeldvLeverkusenBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2008-11-22 | IraklisvOlympiakosSuper League · Greece | 0–3 | Super League · Greece |
| 2008-11-22 | LeedsvHartlepoolLeague One · England | 4–1 | League One · England |
| 2008-11-22 | AlloavQueens ParkLeague One · Scotland | 1–3 | League One · Scotland |
| 2008-11-22 | IpswichvDerbyChampionship · England | 2–0 | Championship · England |
| 2008-11-22 | RoeselarevDenderPro League · Belgium | 2–2 | Pro League · Belgium |
| 2008-11-22 | Dag and RedvNotts CountyLeague Two · England | 6–1 | League Two · England |
| 2008-11-22 | SevillavValenciaLa Liga · Spain | 0–0 | La Liga · Spain |
| 2008-11-22 | RiminivBariSerie B · Italy | 1–1 | Serie B · Italy |
| 2008-11-22 | Leyton OrientvMillwallLeague One · England | 0–0 | League One · England |
| 2008-11-22 | Airdrie UtdvRoss CountyChampionship · Scotland | 0–2 | Championship · Scotland |
| 2008-11-22 | Bristol RvsvSwindonLeague One · England | 2–2 | League One · England |
| 2008-11-22 | Bayern MunichvCottbusBundesliga · Germany | 4–1 | Bundesliga · Germany |
| 2008-11-22 | HeartsvFalkirkPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2008-11-22 | CrewevStockportLeague One · England | 0–3 | League One · England |
| 2008-11-22 | MurciavGimnasticLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |