| 2022-03-05 | PlymouthvMorecambeLeague One · England | 2–0 | League One · England |
| 2022-03-05 | Leyton OrientvStevenageLeague Two · England | 2–2 | League Two · England |
| 2022-03-05 | Ross CountyvSt MirrenPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2022-03-05 | PordenonevPisaSerie B · Italy | 0–1 | Serie B · Italy |
| 2022-03-05 | LiverpoolvWest HamPremier League · England | 1–0 | Premier League · England |
| 2022-03-05 | Raith RvsvAyrChampionship · Scotland | 0–4 | Championship · Scotland |
| 2022-03-05 | Fleetwood TownvIpswichLeague One · England | 0–2 | League One · England |
| 2022-03-05 | CittadellavMonzaSerie B · Italy | 1–2 | Serie B · Italy |
| 2022-03-05 | RB LeipzigvFreiburgBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-03-05 | Vancouver WhitecapsvNew York CityMLS · United States | 0–0 | MLS · United States |
| 2022-03-05 | Bristol CityvBirminghamChampionship · England | 1–2 | Championship · England |
| 2022-03-05 | NorthamptonvTranmereLeague Two · England | 3–2 | League Two · England |
| 2022-03-05 | Quevilly RouenvLe HavreLigue 2 · France | 0–2 | Ligue 2 · France |
| 2022-03-05 | OxfordvBurtonLeague One · England | 4–1 | League One · England |
| 2022-03-05 | St PaulivKarlsruhe2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2022-03-05 | AldershotvStockportNational League · England | 0–2 | National League · England |
| 2022-03-05 | Chicago FirevOrlando CityMLS · United States | 0–0 | MLS · United States |
| 2022-03-05 | StirlingvStenhousemuirLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2022-03-05 | TorquayvBromleyNational League · England | 0–0 | National League · England |
| 2022-03-05 | BochumvGreuther FurthBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2022-03-05 | SeraingvClub BruggePro League · Belgium | 0–5 | Pro League · Belgium |
| 2022-03-05 | Sligo RoversvDundalkPremier Division · Ireland | 0–0 | Premier Division · Ireland |
| 2022-03-05 | Cercle BruggevGenkPro League · Belgium | 2–2 | Pro League · Belgium |
| 2022-03-05 | Willem IIvHeerenveenEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2022-03-05 | BoavistavSp BragaPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2022-03-05 | FulhamvBlackburnChampionship · England | 2–0 | Championship · England |
| 2022-03-05 | Barracas CentralvAldosiviCopa De La Liga Profesional · Argentina | 2–1 | Copa De La Liga Profesional · Argentina |
| 2022-03-05 | QPRvCardiffChampionship · England | 1–2 | Championship · England |
| 2022-03-05 | Real Salt LakevSeattle SoundersMLS · United States | 1–0 | MLS · United States |
| 2022-03-05 | WolfsburgvUnion BerlinBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2022-03-05 | NewcastlevBrightonPremier League · England | 2–1 | Premier League · England |
| 2022-03-05 | QueretarovAtlasLiga MX · Mexico | 0–3 | Liga MX · Mexico |
| 2022-03-05 | Gimnasia L.P.vArgentinos JrsCopa De La Liga Profesional · Argentina | 2–2 | Copa De La Liga Profesional · Argentina |
| 2022-03-05 | Minnesota UnitedvNashville SCMLS · United States | 1–1 | MLS · United States |
| 2022-03-05 | OsasunavVillarrealLa Liga · Spain | 1–0 | La Liga · Spain |
| 2022-03-05 | Real MadridvSociedadLa Liga · Spain | 4–1 | La Liga · Spain |
| 2022-03-05 | SochauxvGuingampLigue 2 · France | 1–0 | Ligue 2 · France |
| 2022-03-05 | MontrosevEast FifeLeague One · Scotland | 0–0 | League One · Scotland |
| 2022-03-05 | NorwichvBrentfordPremier League · England | 1–3 | Premier League · England |
| 2022-03-05 | GrimsbyvWokingNational League · England | 1–0 | National League · England |
| 2022-03-05 | FC Rapid BucurestivAcademica ClinceniSuperliga · Romania | 1–0 | Superliga · Romania |
| 2022-03-05 | OldhamvCarlisleLeague Two · England | 1–2 | League Two · England |
| 2022-03-05 | MotherwellvDundeePremiership · Scotland | 1–1 | Premiership · Scotland |
| 2022-03-05 | New England RevolutionvFC DallasMLS · United States | 1–0 | MLS · United States |
| 2022-03-05 | Cove RangersvPeterheadLeague One · Scotland | 5–2 | League One · Scotland |
| 2022-03-05 | StokevBlackpoolChampionship · England | 0–1 | Championship · England |
| 2022-03-05 | Sporting Kansas CityvHouston DynamoMLS · United States | 1–0 | MLS · United States |
| 2022-03-05 | HullvWest BromChampionship · England | 0–2 | Championship · England |
| 2022-03-05 | NecaxavTolucaLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2022-03-05 | SalfordvForest GreenLeague Two · England | 1–1 | League Two · England |