| 2021-03-21 | MidtjyllandvVejleSuperliga · Denmark | 5–0 | Superliga · Denmark |
| 2021-03-21 | AdmiravSturm GrazBundesliga · Austria | 0–0 | Bundesliga · Austria |
| 2021-03-21 | AltachvRiedBundesliga · Austria | 2–1 | Bundesliga · Austria |
| 2021-03-21 | RomavNapoliSerie A · Italy | 0–2 | Serie A · Italy |
| 2021-03-21 | TolucavPueblaLiga MX · Mexico | 4–4 | Liga MX · Mexico |
| 2021-03-21 | NordsjaellandvSonderjyskeSuperliga · Denmark | 2–1 | Superliga · Denmark |
| 2021-03-21 | Club TijuanavQueretaroLiga MX · Mexico | 3–1 | Liga MX · Mexico |
| 2021-03-21 | MaritimovFamalicaoPrimeira Liga · Portugal | 0–4 | Primeira Liga · Portugal |
| 2021-03-21 | Warta PoznanvPodbeskidzieEkstraklasa · Poland | 2–0 | Ekstraklasa · Poland |
| 2021-03-21 | Asteras TripolisvPanathinaikosSuper League · Greece | 2–2 | Super League · Greece |
| 2021-03-21 | Shonan BellmarevCerezo OsakaJ1 League · Japan | 0–0 | J1 League · Japan |
| 2021-03-21 | Oita TrinitavSanfrecce HiroshimaJ1 League · Japan | 1–3 | J1 League · Japan |
| 2021-03-21 | DenizlisporvBuyuksehyrSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2021-03-21 | HerthavLeverkusenBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2021-03-21 | ServettevVaduzSuper League · Switzerland | 1–2 | Super League · Switzerland |
| 2021-03-21 | Sagan TosuvAvispa FukuokaJ1 League · Japan | 0–0 | J1 League · Japan |
| 2021-03-21 | MontpelliervBordeauxLigue 1 · France | 3–1 | Ligue 1 · France |
| 2021-03-21 | SociedadvBarcelonaLa Liga · Spain | 1–6 | La Liga · Spain |
| 2021-03-21 | NantesvLorientLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-03-21 | Greuther FurthvNurnberg2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2021-03-21 | HoffenheimvMainzBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2021-03-21 | AlcorconvVallecanoLa Liga 2 · Spain | 0–3 | La Liga 2 · Spain |
| 2021-03-21 | VitessevWillem IIEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2021-03-21 | LugovCastellonLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-03-21 | Colon Santa FEvRosario CentralCopa De La Liga Profesional · Argentina | 0–0 | Copa De La Liga Profesional · Argentina |
| 2021-03-20 | Le HavrevSochauxLigue 2 · France | 0–2 | Ligue 2 · France |
| 2021-03-20 | PeterheadvAirdrie UtdLeague One · Scotland | 1–0 | League One · Scotland |
| 2021-03-20 | FC ArgesvAcademica ClinceniSuperliga · Romania | 1–1 | Superliga · Romania |
| 2021-03-20 | Volos NFCvOFI CreteSuper League · Greece | 0–0 | Super League · Greece |
| 2021-03-20 | LivingstonvHibernianPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2021-03-20 | Slask WroclawvWisla PlockEkstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2021-03-20 | Ein FrankfurtvUnion BerlinBundesliga · Germany | 5–2 | Bundesliga · Germany |
| 2021-03-20 | MouscronvOostendePro League · Belgium | 0–1 | Pro League · Belgium |
| 2021-03-20 | WeymouthvWealdstoneNational League · England | 4–0 | National League · England |
| 2021-03-20 | ElginvEdinburgh CityLeague Two · Scotland | 1–2 | League Two · Scotland |
| 2021-03-20 | PatronatovHuracanCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2021-03-20 | ChateaurouxvCaenLigue 2 · France | 2–2 | Ligue 2 · France |
| 2021-03-20 | LuganovBaselSuper League · Switzerland | 2–1 | Super League · Switzerland |
| 2021-03-20 | DunfermlinevInverness CChampionship · Scotland | 0–1 | Championship · Scotland |
| 2021-03-20 | BarnsleyvSheffield WedsChampionship · England | 1–2 | Championship · England |
| 2021-03-20 | BarnetvChesterfieldNational League · England | 0–2 | National League · England |
| 2021-03-20 | LASKvSalzburgBundesliga · Austria | 0–1 | Bundesliga · Austria |
| 2021-03-20 | BraunschweigvDarmstadt2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-03-20 | MallorcavOviedoLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-03-20 | Fleetwood TownvSwindonLeague One · England | 0–2 | League One · England |
| 2021-03-20 | NicevMarseilleLigue 1 · France | 3–0 | Ligue 1 · France |
| 2021-03-20 | TrabzonsporvAnkaragucuSüper Lig · Turkey | 4–1 | Süper Lig · Turkey |
| 2021-03-20 | VicenzavPescaraSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-03-20 | ValenciennesvAuxerreLigue 2 · France | 2–2 | Ligue 2 · France |
| 2021-03-20 | Pau FCvDunkerqueLigue 2 · France | 3–1 | Ligue 2 · France |