| 2022-03-06 | Nagoya GrampusvSagan TosuJ1 League · Japan | 1–1 | J1 League · Japan |
| 2022-03-06 | MoreirensevMaritimoPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2022-03-06 | NantesvMontpellierLigue 1 · France | 2–0 | Ligue 1 · France |
| 2022-03-06 | FiorentinavVeronaSerie A · Italy | 1–1 | Serie A · Italy |
| 2022-03-06 | BanfieldvDefensa y JusticiaCopa De La Liga Profesional · Argentina | 2–3 | Copa De La Liga Profesional · Argentina |
| 2022-03-06 | LamiavPAOKSuper League · Greece | 0–2 | Super League · Greece |
| 2022-03-06 | LivingstonvCelticPremiership · Scotland | 1–3 | Premiership · Scotland |
| 2022-03-06 | AalborgvVejleSuperliga · Denmark | 0–0 | Superliga · Denmark |
| 2022-03-06 | Lokomotiv MoscowvKhimkiPremier League · Russia | 3–2 | Premier League · Russia |
| 2022-03-06 | AjaxvWaalwijkEredivisie · Netherlands | 3–2 | Eredivisie · Netherlands |
| 2022-03-06 | Fortuna DusseldorfvIngolstadt2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2022-03-06 | SonderjyskevOdenseSuperliga · Denmark | 2–2 | Superliga · Denmark |
| 2022-03-06 | CFR ClujvDin. BucurestiSuperliga · Romania | 4–1 | Superliga · Romania |
| 2022-03-06 | Gamba OsakavKawasaki FrontaleJ1 League · Japan | 2–2 | J1 League · Japan |
| 2022-03-06 | GenoavEmpoliSerie A · Italy | 0–0 | Serie A · Italy |
| 2022-03-06 | CartagenavEibarLa Liga 2 · Spain | 4–1 | La Liga 2 · Spain |
| 2022-03-06 | GuimaraesvFamalicaoPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2022-03-06 | Erzgebirge AuevRegensburg2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2022-03-06 | AntalyasporvSivassporSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2022-03-06 | St EtiennevMetzLigue 1 · France | 1–0 | Ligue 1 · France |
| 2022-03-06 | Sanfrecce HiroshimavVissel KobeJ1 League · Japan | 1–1 | J1 League · Japan |
| 2022-03-06 | AtromitosvPanathinaikosSuper League · Greece | 0–2 | Super League · Greece |
| 2022-03-06 | RennesvAngersLigue 1 · France | 2–0 | Ligue 1 · France |
| 2022-03-06 | Cerezo OsakavFC TokyoJ1 League · Japan | 0–1 | J1 League · Japan |
| 2022-03-06 | Guadalajara ChivasvSantos LagunaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2022-03-06 | For SittardvZwolleEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2022-03-06 | GentvWaregemPro League · Belgium | 2–1 | Pro League · Belgium |
| 2022-03-06 | Krylya SovetovvArsenal TulaPremier League · Russia | 2–2 | Premier League · Russia |
| 2022-03-06 | LugovAlcorconLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2022-03-06 | ReimsvStrasbourgLigue 1 · France | 1–1 | Ligue 1 · France |
| 2022-03-06 | ElchevBarcelonaLa Liga · Spain | 1–2 | La Liga · Spain |
| 2022-03-06 | St. GallenvSionSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2022-03-06 | WatfordvArsenalPremier League · England | 2–3 | Premier League · England |
| 2022-03-06 | Avispa FukuokavHokkaido Consadole SapporoJ1 League · Japan | 0–0 | J1 League · Japan |
| 2022-03-06 | SilkeborgvBrondbySuperliga · Denmark | 0–1 | Superliga · Denmark |
| 2022-03-06 | AmorebietavMalagaLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2022-03-06 | Gornik Z.vCracoviaEkstraklasa · Poland | 3–0 | Ekstraklasa · Poland |
| 2022-03-06 | Wolfsberger ACvLASKBundesliga · Austria | 1–0 | Bundesliga · Austria |
| 2022-03-06 | LeganesvMirandesLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2022-03-06 | PSV EindhovenvHeraclesEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2022-03-06 | Gaz Metan MediasvChindia TargovisteSuperliga · Romania | 0–4 | Superliga · Romania |
| 2022-03-06 | Boca JuniorsvHuracanCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2022-03-06 | Man CityvMan UnitedPremier League · England | 4–1 | Premier League · England |
| 2022-03-05 | Queen of SthvMortonChampionship · Scotland | 3–0 | Championship · Scotland |
| 2022-03-05 | MaidenheadvAltrinchamNational League · England | 0–0 | National League · England |
| 2022-03-05 | Aston VillavSouthamptonPremier League · England | 4–0 | Premier League · England |
| 2022-03-05 | CagliarivLazioSerie A · Italy | 0–3 | Serie A · Italy |
| 2022-03-05 | GillinghamvBoltonLeague One · England | 0–3 | League One · England |
| 2022-03-05 | UdinesevSampdoriaSerie A · Italy | 2–1 | Serie A · Italy |
| 2022-03-05 | WiganvAFC WimbledonLeague One · England | 1–0 | League One · England |