| 2022-03-12 | Las PalmasvGironaLa Liga 2 · Spain | 1–3 | La Liga 2 · Spain |
| 2022-03-12 | MalagavPonferradinaLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2022-03-12 | Queens ParkvAlloaLeague One · Scotland | 1–1 | League One · Scotland |
| 2022-03-12 | Kashiwa ReysolvAvispa FukuokaJ1 League · Japan | 1–0 | J1 League · Japan |
| 2022-03-12 | AroucavPacos FerreiraPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2022-03-12 | BirminghamvHullChampionship · England | 0–0 | Championship · England |
| 2022-03-12 | Queen of SthvRaith RvsChampionship · Scotland | 0–1 | Championship · Scotland |
| 2022-03-12 | Columbus CrewvToronto FCMLS · United States | 2–1 | MLS · United States |
| 2022-03-12 | Hokkaido Consadole SapporovYokohama F. MarinosJ1 League · Japan | 1–1 | J1 League · Japan |
| 2022-03-12 | HoffenheimvBayern MunichBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-03-12 | YeovilvGrimsbyNational League · England | 0–2 | National League · England |
| 2022-03-12 | FrosinonevAlessandriaSerie B · Italy | 3–0 | Serie B · Italy |
| 2022-03-12 | HamiltonvDunfermlineChampionship · Scotland | 2–2 | Championship · Scotland |
| 2022-03-12 | Inter MiamivLos Angeles FCMLS · United States | 0–2 | MLS · United States |
| 2022-03-12 | Milton Keynes DonsvWiganLeague One · England | 1–1 | League One · England |
| 2022-03-12 | MonzavVicenzaSerie B · Italy | 4–0 | Serie B · Italy |
| 2022-03-12 | BrightonvLiverpoolPremier League · England | 0–2 | Premier League · England |
| 2022-03-12 | Kings LynnvTorquayNational League · England | 2–3 | National League · England |
| 2022-03-12 | UfavPari NNPremier League · Russia | 0–0 | Premier League · Russia |
| 2022-03-12 | SpalvAscoliSerie B · Italy | 1–2 | Serie B · Italy |
| 2022-03-12 | RegginavPerugiaSerie B · Italy | 0–1 | Serie B · Italy |
| 2022-03-12 | GranadavElcheLa Liga · Spain | 0–1 | La Liga · Spain |
| 2022-03-12 | Nott'm ForestvReadingChampionship · England | 4–0 | Championship · England |
| 2022-03-12 | SpeziavCagliariSerie A · Italy | 2–0 | Serie A · Italy |
| 2022-03-12 | MillwallvMiddlesbroughChampionship · England | 0–0 | Championship · England |
| 2022-03-12 | FalkirkvAirdrie UtdLeague One · Scotland | 1–4 | League One · Scotland |
| 2022-03-12 | New York CityvCF MontrealMLS · United States | 4–1 | MLS · United States |
| 2022-03-12 | Kawasaki FrontalevNagoya GrampusJ1 League · Japan | 1–0 | J1 League · Japan |
| 2022-03-12 | Paris FCvNiortLigue 2 · France | 2–0 | Ligue 2 · France |
| 2022-03-12 | ValenciennesvDijonLigue 2 · France | 0–0 | Ligue 2 · France |
| 2022-03-12 | BlackburnvBristol CityChampionship · England | 0–1 | Championship · England |
| 2022-03-12 | Kelty HeartsvAlbion RvsLeague Two · Scotland | 3–1 | League Two · Scotland |
| 2022-03-12 | WalsallvSuttonLeague Two · England | 1–0 | League Two · England |
| 2022-03-12 | Seattle SoundersvLos Angeles GalaxyMLS · United States | 3–2 | MLS · United States |
| 2022-03-12 | Warta PoznanvGornik Z.Ekstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2022-03-12 | BarnsleyvFulhamChampionship · England | 1–1 | Championship · England |
| 2022-03-12 | ZurichvSt. GallenSuper League · Switzerland | 0–3 | Super League · Switzerland |
| 2022-03-12 | SionvLuganoSuper League · Switzerland | 0–3 | Super League · Switzerland |
| 2022-03-12 | SwindonvOldhamLeague Two · England | 1–0 | League Two · England |
| 2022-03-12 | Houston DynamovVancouver WhitecapsMLS · United States | 2–1 | MLS · United States |
| 2022-03-12 | DunkerquevPau FCLigue 2 · France | 1–0 | Ligue 2 · France |
| 2022-03-12 | BurtonvFleetwood TownLeague One · England | 3–2 | League One · England |
| 2022-03-12 | Cove RangersvClydeLeague One · Scotland | 4–1 | League One · Scotland |
| 2022-03-12 | OostendevClub BruggePro League · Belgium | 1–3 | Pro League · Belgium |
| 2022-03-12 | WaalwijkvHeerenveenEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2022-03-12 | Shonan BellmarevKyotoJ1 League · Japan | 1–1 | J1 League · Japan |
| 2022-03-12 | SalernitanavSassuoloSerie A · Italy | 2–2 | Serie A · Italy |
| 2022-03-12 | PaderbornvFortuna Dusseldorf2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2022-03-12 | PordenonevComoSerie B · Italy | 1–1 | Serie B · Italy |
| 2022-03-12 | ScunthorpevColchesterLeague Two · England | 1–3 | League Two · England |