| 2022-03-12 | CarlislevNorthamptonLeague Two · England | 2–1 | League Two · England |
| 2022-03-12 | HataysporvKaragumrukSüper Lig · Turkey | 3–0 | Süper Lig · Turkey |
| 2022-03-12 | KasimpasavRizesporSüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2022-03-12 | MirandesvCartagenaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2022-03-12 | AldosivivTigreCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2022-03-12 | FreiburgvWolfsburgBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2022-03-12 | WokingvMaidenheadNational League · England | 1–0 | National League · England |
| 2022-03-12 | AltrinchamvEastleighNational League · England | 4–0 | National League · England |
| 2022-03-12 | Sheffield WedsvCambridgeLeague One · England | 6–0 | League One · England |
| 2022-03-12 | MilanvEmpoliSerie A · Italy | 1–0 | Serie A · Italy |
| 2022-03-12 | EstorilvPortimonensePrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2022-03-12 | AFC WimbledonvLincolnLeague One · England | 0–2 | League One · England |
| 2022-03-12 | Sparta RotterdamvGo Ahead EaglesEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2022-03-12 | StranraervCowdenbeathLeague Two · Scotland | 3–0 | League Two · Scotland |
| 2022-03-12 | MorecambevCheltenhamLeague One · England | 1–3 | League One · England |
| 2022-03-12 | NecaxavQueretaroLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2022-03-12 | GetafevValenciaLa Liga · Spain | 0–0 | La Liga · Spain |
| 2022-03-12 | CFR ClujvFC VoluntariSuperliga · Romania | 3–1 | Superliga · Romania |
| 2022-03-12 | Arsenal TulavDynamo MoscowPremier League · Russia | 1–4 | Premier League · Russia |
| 2022-03-12 | PeterborovStokeChampionship · England | 2–2 | Championship · England |
| 2022-03-12 | MortonvPartickChampionship · Scotland | 2–1 | Championship · Scotland |
| 2022-03-12 | Rosario CentralvBarracas CentralCopa De La Liga Profesional · Argentina | 1–3 | Copa De La Liga Profesional · Argentina |
| 2022-03-12 | TrabzonsporvGoztepSüper Lig · Turkey | 4–2 | Süper Lig · Turkey |
| 2022-03-12 | IbizavLeganesLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2022-03-12 | HeidenheimvWerder Bremen2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2022-03-12 | IwatavGamba OsakaJ1 League · Japan | 1–1 | J1 League · Japan |
| 2022-03-12 | Club LeonvTigres UANLLiga MX · Mexico | 0–3 | Liga MX · Mexico |
| 2022-03-12 | CracoviavPogon SzczecinEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2022-03-12 | AjacciovBastiaLigue 2 · France | 0–1 | Ligue 2 · France |
| 2022-03-12 | Lokomotiv MoscowvCSKA MoscowPremier League · Russia | 1–2 | Premier League · Russia |
| 2022-03-12 | WaregemvEupenPro League · Belgium | 3–0 | Pro League · Belgium |
| 2022-03-12 | HuracanvGodoy CruzCopa De La Liga Profesional · Argentina | 1–3 | Copa De La Liga Profesional · Argentina |
| 2022-03-12 | AltayvYeni MalatyasporSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2022-03-12 | JuarezvAtlasLiga MX · Mexico | 1–2 | Liga MX · Mexico |
| 2022-03-12 | Man UnitedvTottenhamPremier League · England | 3–2 | Premier League · England |
| 2022-03-12 | CaenvToulouseLigue 2 · France | 4–1 | Ligue 2 · France |
| 2022-03-12 | AltachvHartbergBundesliga · Austria | 0–0 | Bundesliga · Austria |
| 2022-03-12 | WycombevRotherhamLeague One · England | 0–0 | League One · England |
| 2022-03-12 | MontpelliervNiceLigue 1 · France | 0–0 | Ligue 1 · France |
| 2022-03-12 | MechelenvCharleroiPro League · Belgium | 2–2 | Pro League · Belgium |
| 2022-03-12 | BlackpoolvSwanseaChampionship · England | 1–0 | Championship · England |
| 2022-03-12 | Chindia TargovistevU Craiova 1948Superliga · Romania | 0–0 | Superliga · Romania |
| 2022-03-12 | Piast GliwicevLechia GdanskEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2022-03-12 | StenhousemuirvEdinburgh CityLeague Two · Scotland | 0–0 | League Two · Scotland |
| 2022-03-12 | Union BerlinvStuttgartBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-03-12 | Le HavrevNimesLigue 2 · France | 0–1 | Ligue 2 · France |
| 2022-03-12 | TroyesvNantesLigue 1 · France | 1–0 | Ligue 1 · France |
| 2022-03-12 | Cercle BruggevKortrijkPro League · Belgium | 2–0 | Pro League · Belgium |
| 2022-03-12 | Annan AthleticvElginLeague Two · Scotland | 2–1 | League Two · Scotland |
| 2022-03-12 | DoncastervGillinghamLeague One · England | 0–1 | League One · England |