| 2022-03-13 | Sepsi Sf. GheorghevMioveniSuperliga · Romania | 3–1 | Superliga · Romania |
| 2022-03-13 | BaselvServetteSuper League · Switzerland | 2–0 | Super League · Switzerland |
| 2022-03-13 | Greuther FurthvRB LeipzigBundesliga · Germany | 1–6 | Bundesliga · Germany |
| 2022-03-13 | ChelseavNewcastlePremier League · England | 1–0 | Premier League · England |
| 2022-03-13 | VallecanovSevillaLa Liga · Spain | 1–1 | La Liga · Spain |
| 2022-03-13 | DC UnitedvChicago FireMLS · United States | 0–2 | MLS · United States |
| 2022-03-13 | Atl. San LuisvPueblaLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2022-03-13 | Ein FrankfurtvBochumBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2022-03-13 | A. KlagenfurtvSK RapidBundesliga · Austria | 1–3 | Bundesliga · Austria |
| 2022-03-13 | BetisvAth BilbaoLa Liga · Spain | 1–0 | La Liga · Spain |
| 2022-03-13 | StandardvSeraingPro League · Belgium | 0–1 | Pro League · Belgium |
| 2022-03-13 | West HamvAston VillaPremier League · England | 2–1 | Premier League · England |
| 2022-03-13 | AnderlechtvAntwerpPro League · Belgium | 2–1 | Pro League · Belgium |
| 2022-03-13 | TolucavPachucaLiga MX · Mexico | 0–3 | Liga MX · Mexico |
| 2022-03-13 | For SittardvWillem IIEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2022-03-13 | LuzernvGrasshoppersSuper League · Switzerland | 1–0 | Super League · Switzerland |
| 2022-03-13 | OviedovValladolidLa Liga 2 · Spain | 3–0 | La Liga 2 · Spain |
| 2022-03-13 | UtrechtvPSV EindhovenEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2022-03-13 | ClermontvLorientLigue 1 · France | 0–2 | Ligue 1 · France |
| 2022-03-13 | Portland TimbersvAustin FCMLS · United States | 1–0 | MLS · United States |
| 2022-03-13 | Talleres CordobavSan LorenzoCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2022-03-13 | Paris SGvBordeauxLigue 1 · France | 3–0 | Ligue 1 · France |
| 2022-03-13 | Strasbourgv MonacoLigue 1 · France | 1–0 | Ligue 1 · France |
| 2022-03-13 | Union de Santa FevBanfieldCopa De La Liga Profesional · Argentina | 2–1 | Copa De La Liga Profesional · Argentina |
| 2022-03-13 | ArsenalvLeicesterPremier League · England | 2–0 | Premier League · England |
| 2022-03-13 | LutonvQPRChampionship · England | 1–2 | Championship · England |
| 2022-03-13 | ZwollevFeyenoordEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2022-03-13 | Slask WroclawvRadomiak RadomEkstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2022-03-13 | BrondbyvAarhusSuperliga · Denmark | 1–1 | Superliga · Denmark |
| 2022-03-13 | New York Red BullsvMinnesota UnitedMLS · United States | 0–1 | MLS · United States |
| 2022-03-13 | Cruz AzulvUNAM PumasLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2022-03-13 | Sagan TosuvUrawa RedsJ1 League · Japan | 1–0 | J1 League · Japan |
| 2022-03-13 | AtalantavGenoaSerie A · Italy | 0–0 | Serie A · Italy |
| 2022-03-13 | Beerschot VAvGentPro League · Belgium | 0–2 | Pro League · Belgium |
| 2022-03-13 | KayserisporvKonyasporSüper Lig · Turkey | 2–3 | Süper Lig · Turkey |
| 2022-03-13 | Sp BragavGil VicentePrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2022-03-13 | KhimkivSochiPremier League · Russia | 0–0 | Premier League · Russia |
| 2022-03-13 | OlympiakosvArisSuper League · Greece | 2–1 | Super League · Greece |
| 2022-03-13 | LeedsvNorwichPremier League · England | 2–1 | Premier League · England |
| 2022-03-13 | GenkvSt TruidenPro League · Belgium | 0–1 | Pro League · Belgium |
| 2022-03-13 | AlanyasporvFenerbahceSüper Lig · Turkey | 2–5 | Süper Lig · Turkey |
| 2022-03-13 | UralvAkhmat GroznyPremier League · Russia | 0–0 | Premier League · Russia |
| 2022-03-13 | New England RevolutionvReal Salt LakeMLS · United States | 2–3 | MLS · United States |
| 2022-03-13 | WislavLech PoznanEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2022-03-13 | AlcorconvHuescaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2022-03-13 | PanathinaikosvAEKSuper League · Greece | 1–1 | Super League · Greece |
| 2022-03-13 | MaritimovGuimaraesPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2022-03-13 | BrestvMarseilleLigue 1 · France | 1–4 | Ligue 1 · France |
| 2022-03-13 | Colorado RapidsvSporting Kansas CityMLS · United States | 2–0 | MLS · United States |
| 2022-03-13 | HannovervNurnberg2. Bundesliga · Germany | 0–3 | 2. Bundesliga · Germany |