| 2021-04-03 | HeidenheimvGreuther Furth2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2021-04-03 | LarisavPanetolikosSuper League · Greece | 1–1 | Super League · Greece |
| 2021-04-03 | Boca JuniorsvDefensa y JusticiaCopa De La Liga Profesional · Argentina | 2–1 | Copa De La Liga Profesional · Argentina |
| 2021-04-03 | RizesporvKaragumrukSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2021-04-03 | GranadavVillarrealLa Liga · Spain | 0–3 | La Liga · Spain |
| 2021-04-03 | ChelseavWest BromPremier League · England | 2–5 | Premier League · England |
| 2021-04-03 | TroyesvGuingampLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-04-03 | RodezvChamblyLigue 2 · France | 2–2 | Ligue 2 · France |
| 2021-04-03 | Sarmiento JuninvAtl. TucumanCopa De La Liga Profesional · Argentina | 1–2 | Copa De La Liga Profesional · Argentina |
| 2021-04-03 | Willem IIvAZ AlkmaarEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2021-04-03 | HuddersfieldvBrentfordChampionship · England | 1–1 | Championship · England |
| 2021-04-03 | TwentevVitesseEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2021-04-03 | GrenoblevChateaurouxLigue 2 · France | 2–2 | Ligue 2 · France |
| 2021-04-03 | BolognavInterSerie A · Italy | 0–1 | Serie A · Italy |
| 2021-04-03 | RiedvHartbergBundesliga · Austria | 3–2 | Bundesliga · Austria |
| 2021-04-03 | SouthendvCarlisleLeague Two · England | 0–2 | League Two · England |
| 2021-04-03 | Central CordobavPlatenseCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2021-04-03 | LeverkusenvSchalke 04Bundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-04-03 | PueblavMazatlan FCLiga MX · Mexico | 3–1 | Liga MX · Mexico |
| 2021-04-03 | Nagoya GrampusvFC TokyoJ1 League · Japan | 0–0 | J1 League · Japan |
| 2021-04-03 | TorinovJuventusSerie A · Italy | 2–2 | Serie A · Italy |
| 2021-04-03 | Queens ParkvStirlingLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2021-04-03 | DortmundvEin FrankfurtBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2021-04-02 | BoltonvColchesterLeague Two · England | 0–0 | League Two · England |
| 2021-04-02 | VicenzavCittadellaSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-04-02 | DoncastervCharltonLeague One · England | 0–1 | League One · England |
| 2021-04-02 | Gaz Metan MediasvAstraSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-04-02 | BradfordvForest GreenLeague Two · England | 4–1 | League Two · England |
| 2021-04-02 | AlmeriavVallecanoLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-04-02 | Academica ClincenivPoli IasiSuperliga · Romania | 2–1 | Superliga · Romania |
| 2021-04-02 | Shamrock RoversvDundalkPremier Division · Ireland | 2–1 | Premier Division · Ireland |
| 2021-04-02 | BarnetvSolihullNational League · England | 0–2 | National League · England |
| 2021-04-02 | Virtus EntellavMonzaSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-04-02 | Fleetwood TownvPeterboroLeague One · England | 0–1 | League One · England |
| 2021-04-02 | AccringtonvBurtonLeague One · England | 0–0 | League One · England |
| 2021-04-02 | PescaravPisaSerie B · Italy | 3–1 | Serie B · Italy |
| 2021-04-02 | PlymouthvAFC WimbledonLeague One · England | 1–0 | League One · England |
| 2021-04-02 | SwindonvBlackpoolLeague One · England | 0–2 | League One · England |
| 2021-04-02 | Bristol CityvStokeChampionship · England | 0–2 | Championship · England |
| 2021-04-02 | Boreham WoodvSuttonNational League · England | 0–0 | National League · England |
| 2021-04-02 | WycombevBlackburnChampionship · England | 1–0 | Championship · England |
| 2021-04-02 | VeneziavRegginaSerie B · Italy | 0–2 | Serie B · Italy |
| 2021-04-02 | CardiffvNott'm ForestChampionship · England | 0–1 | Championship · England |
| 2021-04-02 | CosenzavAscoliSerie B · Italy | 2–1 | Serie B · Italy |
| 2021-04-02 | QPRvCoventryChampionship · England | 3–0 | Championship · England |
| 2021-04-02 | WalsallvHarrogateLeague Two · England | 0–0 | League Two · England |
| 2021-04-02 | PrestonvNorwichChampionship · England | 1–1 | Championship · England |
| 2021-04-02 | EastleighvChesterfieldNational League · England | 0–1 | National League · England |
| 2021-04-02 | WeymouthvMaidenheadNational League · England | 2–1 | National League · England |
| 2021-04-02 | LeccevSalernitanaSerie B · Italy | 2–0 | Serie B · Italy |