| 2021-04-03 | OostendevWaasland-BeverenPro League · Belgium | 0–2 | Pro League · Belgium |
| 2021-04-03 | JuarezvCruz AzulLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-04-03 | Real MadridvEibarLa Liga · Spain | 2–0 | La Liga · Spain |
| 2021-04-03 | ClermontvNiortLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-04-03 | MainzvBielefeldBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-04-03 | LeedsvSheffield UnitedPremier League · England | 2–1 | Premier League · England |
| 2021-04-03 | AtromitosvApollonSuper League · Greece | 1–1 | Super League · Greece |
| 2021-04-03 | BochumvHolstein Kiel2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2021-04-03 | ToulousevNancyLigue 2 · France | 4–1 | Ligue 2 · France |
| 2021-04-03 | PortovSanta ClaraPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2021-04-03 | BeneventovParmaSerie A · Italy | 2–2 | Serie A · Italy |
| 2021-04-03 | LeicestervMan CityPremier League · England | 0–2 | Premier League · England |
| 2021-04-03 | CracoviavLech PoznanEkstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2021-04-03 | CagliarivVeronaSerie A · Italy | 0–2 | Serie A · Italy |
| 2021-04-03 | FC HermannstadtvFC ArgesSuperliga · Romania | 4–1 | Superliga · Romania |
| 2021-04-03 | LegiavPogon SzczecinEkstraklasa · Poland | 4–2 | Ekstraklasa · Poland |
| 2021-04-03 | LaziovSpeziaSerie A · Italy | 2–1 | Serie A · Italy |
| 2021-04-03 | LensvLyonLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-04-03 | DroghedavFinn HarpsPremier Division · Ireland | 1–1 | Premier Division · Ireland |
| 2021-04-03 | KarlsruhevOsnabruck2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2021-04-03 | OFI CretevGianninaSuper League · Greece | 2–1 | Super League · Greece |
| 2021-04-03 | St TruidenvMechelenPro League · Belgium | 2–1 | Pro League · Belgium |
| 2021-04-03 | MilanvSampdoriaSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-04-03 | GironavPonferradinaLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2021-04-03 | CastellonvOviedoLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-04-03 | Gimnasia L.P.vLanusCopa De La Liga Profesional · Argentina | 2–4 | Copa De La Liga Profesional · Argentina |
| 2021-04-03 | ArsenalvLiverpoolPremier League · England | 0–3 | Premier League · England |
| 2021-04-03 | LamiavVolos NFCSuper League · Greece | 1–1 | Super League · Greece |
| 2021-04-03 | Yokohama FCvKashiwa ReysolJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-04-03 | Vegalta SendaivVissel KobeJ1 League · Japan | 0–2 | J1 League · Japan |
| 2021-04-03 | Kawasaki FrontalevOita TrinitaJ1 League · Japan | 2–0 | J1 League · Japan |
| 2021-04-03 | SochauxvParis FCLigue 2 · France | 1–2 | Ligue 2 · France |
| 2021-04-03 | AtalantavUdineseSerie A · Italy | 3–2 | Serie A · Italy |
| 2021-04-03 | BohemiansvSt. PatricksPremier Division · Ireland | 0–1 | Premier Division · Ireland |
| 2021-04-03 | Austria ViennavAltachBundesliga · Austria | 2–0 | Bundesliga · Austria |
| 2021-04-03 | GenoavFiorentinaSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-04-03 | Urawa RedsvKashima AntlersJ1 League · Japan | 2–1 | J1 League · Japan |
| 2021-04-03 | AjacciovValenciennesLigue 2 · France | 3–0 | Ligue 2 · France |
| 2021-04-03 | LogronesvTenerifeLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-04-03 | ArbroathvAlloaChampionship · Scotland | 2–1 | Championship · Scotland |
| 2021-04-03 | Talleres CordobavIndependienteCopa De La Liga Profesional · Argentina | 3–1 | Copa De La Liga Profesional · Argentina |
| 2021-04-03 | M'gladbachvFreiburgBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-04-03 | Dynamo MoscowvUfaPremier League · Russia | 4–0 | Premier League · Russia |
| 2021-04-03 | Sparta RotterdamvZwolleEredivisie · Netherlands | 3–2 | Eredivisie · Netherlands |
| 2021-04-03 | Paris SGvLilleLigue 1 · France | 0–1 | Ligue 1 · France |
| 2021-04-03 | Rubin KazanvSochiPremier League · Russia | 1–0 | Premier League · Russia |
| 2021-04-03 | AugsburgvHoffenheimBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-04-03 | Sanfrecce HiroshimavGamba OsakaJ1 League · Japan | 0–0 | J1 League · Japan |
| 2021-04-03 | OsasunavGetafeLa Liga · Spain | 0–0 | La Liga · Spain |
| 2021-04-03 | KortrijkvClub BruggePro League · Belgium | 1–2 | Pro League · Belgium |