| 2021-04-04 | UNAM PumasvPachucaLiga MX · Mexico | 2–2 | Liga MX · Mexico |
| 2021-04-04 | FC EmmenvWaalwijkEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2021-04-04 | AngersvMontpellierLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-04-04 | NewcastlevTottenhamPremier League · England | 2–2 | Premier League · England |
| 2021-04-04 | HeerenveenvAjaxEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2021-04-04 | Velez SarsfieldvUnion de Santa FeCopa De La Liga Profesional · Argentina | 4–1 | Copa De La Liga Profesional · Argentina |
| 2021-04-04 | KasimpasavBesiktasSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2021-04-04 | SevillavAth MadridLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-04-04 | FC BotosanivViitorul ConstantaSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-04-04 | TambovvCSKA MoscowPremier League · Russia | 1–2 | Premier League · Russia |
| 2021-04-04 | GuimaraesvTondelaPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2021-04-04 | ArisvAsteras TripolisSuper League · Greece | 2–0 | Super League · Greece |
| 2021-04-04 | AtlasvClub TijuanaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-04-04 | Aston VillavFulhamPremier League · England | 3–1 | Premier League · England |
| 2021-04-04 | Arsenal SarandivRiver PlateCopa De La Liga Profesional · Argentina | 0–0 | Copa De La Liga Profesional · Argentina |
| 2021-04-04 | FamalicaovPacos FerreiraPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2021-04-04 | HannovervHamburg2. Bundesliga · Germany | 3–3 | 2. Bundesliga · Germany |
| 2021-04-04 | PanathinaikosvPAOKSuper League · Greece | 3–0 | Super League · Greece |
| 2021-04-04 | FCSBvUniv. CraiovaSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-04-04 | Union BerlinvHerthaBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-04-04 | Cercle BruggevBeerschot VAPro League · Belgium | 2–1 | Pro League · Belgium |
| 2021-04-04 | BordeauxvStrasbourgLigue 1 · France | 2–3 | Ligue 1 · France |
| 2021-04-04 | AlavesvCeltaLa Liga · Spain | 1–3 | La Liga · Spain |
| 2021-04-04 | LorientvBrestLigue 1 · France | 1–0 | Ligue 1 · France |
| 2021-04-04 | SandhausenvWurzburger Kickers2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2021-04-04 | DarmstadtvFortuna Dusseldorf2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2021-04-04 | ServettevLuganoSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2021-04-03 | LausannevLuzernSuper League · Switzerland | 2–1 | Super League · Switzerland |
| 2021-04-03 | WolfsburgvFC KolnBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2021-04-03 | CowdenbeathvAlbion RvsLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2021-04-03 | RB LeipzigvBayern MunichBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2021-04-03 | NapolivCrotoneSerie A · Italy | 4–3 | Serie A · Italy |
| 2021-04-03 | KayserisporvGoztepSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-04-03 | Wisla PlockvPiast GliwiceEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2021-04-03 | Yokohama F. MarinosvShonan BellmareJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-04-03 | St. PoltenvAdmiraBundesliga · Austria | 0–1 | Bundesliga · Austria |
| 2021-04-03 | KrasnodarvAkhmat GroznyPremier League · Russia | 0–5 | Premier League · Russia |
| 2021-04-03 | CaenvPau FCLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-04-03 | Rio AvevGil VicentePrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2021-04-03 | VVV VenlovGroningenEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2021-04-03 | Annan AthleticvElginLeague Two · Scotland | 0–3 | League Two · Scotland |
| 2021-04-03 |  MonacovMetzLigue 1 · France | 4–0 | Ligue 1 · France |
| 2021-04-03 | DunfermlinevHeartsChampionship · Scotland | 0–0 | Championship · Scotland |
| 2021-04-03 | SivassporvTrabzonsporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2021-04-03 | Avispa FukuokavHokkaido Consadole SapporoJ1 League · Japan | 1–2 | J1 League · Japan |
| 2021-04-03 | HataysporvGalatasaraySüper Lig · Turkey | 3–0 | Süper Lig · Turkey |
| 2021-04-03 | Derry CityvWaterfordPremier Division · Ireland | 1–2 | Premier Division · Ireland |
| 2021-04-03 | R. VolgogradvLokomotiv MoscowPremier League · Russia | 0–2 | Premier League · Russia |
| 2021-04-03 | St. GallenvZurichSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2021-04-03 | SassuolovRomaSerie A · Italy | 2–2 | Serie A · Italy |