| 2021-04-05 | FenerbahcevDenizlisporSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2021-04-05 | FuenlabradavZaragozaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-04-05 | SolihullvSuttonNational League · England | 0–0 | National League · England |
| 2021-04-05 | Forest GreenvSalfordLeague Two · England | 0–2 | League Two · England |
| 2021-04-05 | CFR ClujvDin. BucurestiSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-04-05 | MaidenheadvEastleighNational League · England | 0–1 | National League · England |
| 2021-04-05 | AuxerrevLe HavreLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-04-05 | HarrogatevPort ValeLeague Two · England | 0–2 | League Two · England |
| 2021-04-04 | UTA AradvSepsi Sf. GheorgheSuperliga · Romania | 2–0 | Superliga · Romania |
| 2021-04-04 | SalzburgvSturm GrazBundesliga · Austria | 3–1 | Bundesliga · Austria |
| 2021-04-04 | FK RostovvSpartak MoscowPremier League · Russia | 2–3 | Premier League · Russia |
| 2021-04-04 | Guadalajara ChivasvSantos LagunaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-04-04 | RegensburgvErzgebirge Aue2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-04-04 | Shimizu S-PulsevTokushimaJ1 League · Japan | 0–3 | J1 League · Japan |
| 2021-04-04 | MarseillevDijonLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-04-04 | ElchevBetisLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-04-04 | LeganesvSabadellLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-04-04 | AnkaragucuvAntalyasporSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2021-04-04 | SouthamptonvBurnleyPremier League · England | 3–2 | Premier League · England |
| 2021-04-04 | FeyenoordvFor SittardEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2021-04-04 | CharleroivMouscronPro League · Belgium | 1–1 | Pro League · Belgium |
| 2021-04-04 | LugovMalagaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-04-04 | Den HaagvUtrechtEredivisie · Netherlands | 1–4 | Eredivisie · Netherlands |
| 2021-04-04 | Colon Santa FEvArgentinos JrsCopa De La Liga Profesional · Argentina | 0–0 | Copa De La Liga Profesional · Argentina |
| 2021-04-04 | SionvYoung BoysSuper League · Switzerland | 0–3 | Super League · Switzerland |
| 2021-04-04 | NantesvNiceLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-04-04 | NimesvSt EtienneLigue 1 · France | 0–2 | Ligue 1 · France |
| 2021-04-04 | TirolvLASKBundesliga · Austria | 2–0 | Bundesliga · Austria |
| 2021-04-04 | NurnbergvPaderborn2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2021-04-04 | Erzurum BBvKonyasporSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2021-04-04 | StuttgartvWerder BremenBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2021-04-04 | Man UnitedvBrightonPremier League · England | 2–1 | Premier League · England |
| 2021-04-04 | AEKvOlympiakosSuper League · Greece | 1–5 | Super League · Greece |
| 2021-04-04 | AlanyasporvGenclerbirligiSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2021-04-04 | PSV EindhovenvHeraclesEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2021-04-04 | Sp GijonvMirandesLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2021-04-04 | HorsensvOdenseSuperliga · Denmark | 1–1 | Superliga · Denmark |
| 2021-04-04 | Newells Old BoysvHuracanCopa De La Liga Profesional · Argentina | 2–2 | Copa De La Liga Profesional · Argentina |
| 2021-04-04 | AlbacetevEspanolLa Liga 2 · Spain | 0–3 | La Liga 2 · Spain |
| 2021-04-04 | StandardvGentPro League · Belgium | 2–1 | Pro League · Belgium |
| 2021-04-04 | BelenensesvBoavistaPrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2021-04-04 | CadizvValenciaLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-04-04 | Wolfsberger ACvSK RapidBundesliga · Austria | 1–8 | Bundesliga · Austria |
| 2021-04-04 | BuyuksehyrvYeni MalatyasporSüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2021-04-04 | NordsjaellandvAarhusSuperliga · Denmark | 2–0 | Superliga · Denmark |
| 2021-04-04 | Club AmericavNecaxaLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-04-04 | ReimsvRennesLigue 1 · France | 2–2 | Ligue 1 · France |
| 2021-04-04 | UralvArsenal TulaPremier League · Russia | 2–0 | Premier League · Russia |
| 2021-04-04 | MonterreyvAtl. San LuisLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2021-04-04 | Las PalmasvMallorcaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |