| 2022-03-19 | Paris FCvPau FCLigue 2 · France | 1–1 | Ligue 2 · France |
| 2022-03-19 | St MirrenvDundee UnitedPremiership · Scotland | 1–2 | Premiership · Scotland |
| 2022-03-19 | AuxerrevToulouseLigue 2 · France | 1–2 | Ligue 2 · France |
| 2022-03-19 | St JohnstonevMotherwellPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2022-03-19 | SuttonvTranmereLeague Two · England | 1–1 | League Two · England |
| 2022-03-19 | HerthavHoffenheimBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2022-03-19 | OsasunavLevanteLa Liga · Spain | 3–1 | La Liga · Spain |
| 2022-03-19 | St. GallenvLuzernSuper League · Switzerland | 3–2 | Super League · Switzerland |
| 2022-03-19 | Gaz Metan MediasvU Craiova 1948Superliga · Romania | 0–2 | Superliga · Romania |
| 2022-03-19 | IntervFiorentinaSerie A · Italy | 1–1 | Serie A · Italy |
| 2022-03-19 | PlymouthvAccringtonLeague One · England | 4–0 | League One · England |
| 2022-03-19 | CagliarivMilanSerie A · Italy | 0–1 | Serie A · Italy |
| 2022-03-19 | Fleetwood TownvDoncasterLeague One · England | 0–0 | League One · England |
| 2022-03-19 | Akhmat GroznyvLokomotiv MoscowPremier League · Russia | 2–3 | Premier League · Russia |
| 2022-03-19 | BesiktasvHataysporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2022-03-19 | Raith RvsvInverness CChampionship · Scotland | 2–3 | Championship · Scotland |
| 2022-03-19 | CheltenhamvAFC WimbledonLeague One · England | 3–1 | League One · England |
| 2022-03-19 | CharltonvBurtonLeague One · England | 2–0 | League One · England |
| 2022-03-19 | EupenvMechelenPro League · Belgium | 1–1 | Pro League · Belgium |
| 2022-03-19 | ElchevValenciaLa Liga · Spain | 0–1 | La Liga · Spain |
| 2022-03-19 | Leyton OrientvRochdaleLeague Two · England | 3–1 | League Two · England |
| 2022-03-19 | Colon Santa FEvUnion de Santa FeCopa De La Liga Profesional · Argentina | 0–0 | Copa De La Liga Profesional · Argentina |
| 2022-03-19 | VallecanovAth MadridLa Liga · Spain | 0–1 | La Liga · Spain |
| 2022-03-19 | KilmarnockvQueen of SthChampionship · Scotland | 2–1 | Championship · Scotland |
| 2022-03-19 | Shimizu S-PulsevVissel KobeJ1 League · Japan | 0–0 | J1 League · Japan |
| 2022-03-19 | TondelavAroucaPrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2022-03-19 | SochauxvRodezLigue 2 · France | 2–0 | Ligue 2 · France |
| 2022-03-19 | SolihullvEastleighNational League · England | 5–3 | National League · England |
| 2022-03-19 | AberdeenvHibernianPremiership · Scotland | 3–1 | Premiership · Scotland |
| 2022-03-19 | SandhausenvHansa Rostock2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2022-03-19 | Lechia GdanskvLecznaEkstraklasa · Poland | 2–0 | Ekstraklasa · Poland |
| 2022-03-19 | StockportvWealdstoneNational League · England | 4–2 | National League · England |
| 2022-03-19 | ElginvKelty HeartsLeague Two · Scotland | 0–0 | League Two · Scotland |
| 2022-03-19 | ParmavLecceSerie B · Italy | 0–0 | Serie B · Italy |
| 2022-03-19 | GillinghamvSheffield WedsLeague One · England | 0–0 | League One · England |
| 2022-03-19 | ZenitvArsenal TulaPremier League · Russia | 3–0 | Premier League · Russia |
| 2022-03-19 | BromleyvWrexhamNational League · England | 0–0 | National League · England |
| 2022-03-19 | Bristol CityvWest BromChampionship · England | 2–2 | Championship · England |
| 2022-03-19 | Pari NNvSpartak MoscowPremier League · Russia | 1–1 | Premier League · Russia |
| 2022-03-19 | TwentevZwolleEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2022-03-19 | GrenoblevBastiaLigue 2 · France | 1–1 | Ligue 2 · France |
| 2022-03-19 | HarrogatevWalsallLeague Two · England | 1–1 | League Two · England |
| 2022-03-19 | AlloavPeterheadLeague One · Scotland | 1–0 | League One · Scotland |
| 2022-03-19 | PanetolikosvLamiaSuper League · Greece | 1–2 | Super League · Greece |
| 2022-03-19 | AldershotvKings LynnNational League · England | 0–3 | National League · England |
| 2022-03-19 | Albion RvsvForfarLeague Two · Scotland | 0–0 | League Two · Scotland |
| 2022-03-19 | SouthendvAltrinchamNational League · England | 2–0 | National League · England |
| 2022-03-19 | HeartsvLivingstonPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2022-03-19 | SalfordvScunthorpeLeague Two · England | 5–1 | League Two · England |
| 2022-03-19 | MonzavCrotoneSerie B · Italy | 1–0 | Serie B · Italy |