| 2022-03-20 | WolfsburgvLeverkusenBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2022-03-20 | VitessevWaalwijkEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2022-03-20 | Gimnasia L.P.vEstudiantes L.P.Copa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2022-03-20 | LorientvStrasbourgLigue 1 · France | 0–0 | Ligue 1 · France |
| 2022-03-20 | PSV EindhovenvFor SittardEredivisie · Netherlands | 5–0 | Eredivisie · Netherlands |
| 2022-03-20 | RegensburgvPaderborn2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2022-03-20 | DundeevRangersPremiership · Scotland | 1–2 | Premiership · Scotland |
| 2022-03-20 | PortimonensevSp BragaPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2022-03-20 | Willem IIvAZ AlkmaarEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2022-03-20 | FenerbahcevKonyasporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2022-03-20 | AmorebietavAlcorconLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2022-03-20 | Real MadridvBarcelonaLa Liga · Spain | 0–4 | La Liga · Spain |
| 2022-03-20 | Rosario CentralvNewells Old BoysCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2022-03-20 | Dynamo MoscowvFK RostovPremier League · Russia | 1–1 | Premier League · Russia |
| 2022-03-20 | Din. BucurestivSepsi Sf. GheorgheSuperliga · Romania | 0–0 | Superliga · Romania |
| 2022-03-20 | FC CopenhagenvNordsjaellandSuperliga · Denmark | 1–0 | Superliga · Denmark |
| 2022-03-19 | Dag and RedvNotts CountyNational League · England | 1–2 | National League · England |
| 2022-03-19 | HalifaxvTorquayNational League · England | 2–0 | National League · England |
| 2022-03-19 | FrosinonevBeneventoSerie B · Italy | 2–0 | Serie B · Italy |
| 2022-03-19 | FuenlabradavMalagaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2022-03-19 | CambridgevMilton Keynes DonsLeague One · England | 0–1 | League One · England |
| 2022-03-19 | GoztepvAlanyasporSüper Lig · Turkey | 0–2 | Süper Lig · Turkey |
| 2022-03-19 | RegginavCosenzaSerie B · Italy | 1–0 | Serie B · Italy |
| 2022-03-19 | Wisla PlockvSlask WroclawEkstraklasa · Poland | 1–2 | Ekstraklasa · Poland |
| 2022-03-19 | Fortuna DusseldorfvHamburg2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2022-03-19 | LanusvBanfieldCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2022-03-19 | IndependientevRacing ClubCopa De La Liga Profesional · Argentina | 1–2 | Copa De La Liga Profesional · Argentina |
| 2022-03-19 | AmiensvDijonLigue 2 · France | 1–1 | Ligue 2 · France |
| 2022-03-19 | Toronto FCvDC UnitedMLS · United States | 2–1 | MLS · United States |
| 2022-03-19 | Greuther FurthvFreiburgBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2022-03-19 | Farul ConstantavCFR ClujSuperliga · Romania | 0–0 | Superliga · Romania |
| 2022-03-19 | Dover AthleticvYeovilNational League · England | 0–2 | National League · England |
| 2022-03-19 | Los Angeles GalaxyvOrlando CityMLS · United States | 0–1 | MLS · United States |
| 2022-03-19 | AjacciovNimesLigue 2 · France | 1–0 | Ligue 2 · France |
| 2022-03-19 | ChesterfieldvMaidenheadNational League · England | 1–0 | National League · England |
| 2022-03-19 | ReadingvBlackburnChampionship · England | 1–0 | Championship · England |
| 2022-03-19 | OxfordvIpswichLeague One · England | 1–1 | League One · England |
| 2022-03-19 | Kashima AntlersvShonan BellmareJ1 League · Japan | 2–1 | J1 League · Japan |
| 2022-03-19 | Urawa RedsvIwataJ1 League · Japan | 4–1 | J1 League · Japan |
| 2022-03-19 | DunkerquevValenciennesLigue 2 · France | 1–2 | Ligue 2 · France |
| 2022-03-19 | RakowvLegiaEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2022-03-19 | OldhamvExeterLeague Two · England | 0–2 | League Two · England |
| 2022-03-19 | Academica ClincenivFC Rapid BucurestiSuperliga · Romania | 0–1 | Superliga · Romania |
| 2022-03-19 | San LorenzovHuracanCopa De La Liga Profesional · Argentina | 0–0 | Copa De La Liga Profesional · Argentina |
| 2022-03-19 | NiortvQuevilly RouenLigue 2 · France | 2–0 | Ligue 2 · France |
| 2022-03-19 | RotherhamvShrewsburyLeague One · England | 0–3 | League One · England |
| 2022-03-19 | PartickvHamiltonChampionship · Scotland | 0–4 | Championship · Scotland |
| 2022-03-19 | SeraingvOud-Heverlee LeuvenPro League · Belgium | 1–1 | Pro League · Belgium |
| 2022-03-19 | LensvClermontLigue 1 · France | 3–1 | Ligue 1 · France |
| 2022-03-19 | AntwerpvWaregemPro League · Belgium | 1–0 | Pro League · Belgium |