| 2022-03-20 | VeneziavSampdoriaSerie A · Italy | 0–2 | Serie A · Italy |
| 2022-03-20 | ArisvPanathinaikosSuper League · Greece | 0–0 | Super League · Greece |
| 2022-03-20 | AarhusvViborgSuperliga · Denmark | 1–1 | Superliga · Denmark |
| 2022-03-20 | AntalyasporvGiresunsporSüper Lig · Turkey | 4–1 | Süper Lig · Turkey |
| 2022-03-20 | VejlevOdenseSuperliga · Denmark | 2–0 | Superliga · Denmark |
| 2022-03-20 | RennesvMetzLigue 1 · France | 6–1 | Ligue 1 · France |
| 2022-03-20 | GrasshoppersvBaselSuper League · Switzerland | 2–4 | Super League · Switzerland |
| 2022-03-20 | Club BruggevGenkPro League · Belgium | 3–1 | Pro League · Belgium |
| 2022-03-20 | AalborgvBrondbySuperliga · Denmark | 3–0 | Superliga · Denmark |
| 2022-03-20 | SilkeborgvMidtjyllandSuperliga · Denmark | 0–1 | Superliga · Denmark |
| 2022-03-20 | KortrijkvStandardPro League · Belgium | 0–1 | Pro League · Belgium |
| 2022-03-20 | FC KolnvDortmundBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-03-20 | UfavKrasnodarPremier League · Russia | 1–1 | Premier League · Russia |
| 2022-03-20 | St TruidenvBeerschot VAPro League · Belgium | 3–2 | Pro League · Belgium |
| 2022-03-20 | SivassporvAltaySüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2022-03-20 | EspanolvMallorcaLa Liga · Spain | 1–0 | La Liga · Spain |
| 2022-03-20 | FC DallasvPortland TimbersMLS · United States | 4–1 | MLS · United States |
| 2022-03-20 | MarseillevNiceLigue 1 · France | 2–1 | Ligue 1 · France |
| 2022-03-20 | CSKA MoscowvRubin KazanPremier League · Russia | 6–1 | Premier League · Russia |
| 2022-03-20 | BordeauxvMontpellierLigue 1 · France | 0–2 | Ligue 1 · France |
| 2022-03-20 | LeganesvSp GijonLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2022-03-20 | UtrechtvGroningenEredivisie · Netherlands | 1–3 | Eredivisie · Netherlands |
| 2022-03-20 | Club AmericavTolucaLiga MX · Mexico | 3–0 | Liga MX · Mexico |
| 2022-03-20 | Nagoya GrampusvKashiwa ReysolJ1 League · Japan | 1–1 | J1 League · Japan |
| 2022-03-20 | SonderjyskevRanders FCSuperliga · Denmark | 1–1 | Superliga · Denmark |
| 2022-03-20 | RB LeipzigvEin FrankfurtBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2022-03-20 | BolognavAtalantaSerie A · Italy | 0–1 | Serie A · Italy |
| 2022-03-20 | SK RapidvAustria ViennaBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2022-03-20 | River PlatevBoca JuniorsCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2022-03-20 | Radomiak RadomvStal MielecEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2022-03-20 | BenficavEstorilPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2022-03-20 | RomavLazioSerie A · Italy | 3–0 | Serie A · Italy |
| 2022-03-20 | GentvAnderlechtPro League · Belgium | 1–0 | Pro League · Belgium |
| 2022-03-20 | Wolfsberger ACvSalzburgBundesliga · Austria | 1–4 | Bundesliga · Austria |
| 2022-03-20 | BoavistavPortoPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2022-03-20 | AngersvBrestLigue 1 · France | 1–0 | Ligue 1 · France |
| 2022-03-20 | GaziantepvGalatasaraySüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2022-03-20 | Holstein KielvIngolstadt2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2022-03-20 | New York Red BullsvColumbus CrewMLS · United States | 1–1 | MLS · United States |
| 2022-03-20 | Tigres UANLvMonterreyLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2022-03-20 | PordenonevBresciaSerie B · Italy | 1–1 | Serie B · Italy |
| 2022-03-20 | Pacos FerreiravMoreirensePrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2022-03-20 | Gornik Z.vTermalica B-B.Ekstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2022-03-20 | PisavCittadellaSerie B · Italy | 1–0 | Serie B · Italy |
| 2022-03-20 | JuventusvSalernitanaSerie A · Italy | 2–0 | Serie A · Italy |
| 2022-03-20 | PerugiavComoSerie B · Italy | 0–1 | Serie B · Italy |
| 2022-03-20 | SochivKrylya SovetovPremier League · Russia | 2–3 | Premier League · Russia |
| 2022-03-20 | HartbergvLASKBundesliga · Austria | 0–0 | Bundesliga · Austria |
| 2022-03-20 | PonferradinavEibarLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |
| 2022-03-20 |  MonacovParis SGLigue 1 · France | 3–0 | Ligue 1 · France |