| 2021-04-10 | Cercle BruggevOud-Heverlee LeuvenPro League · Belgium | 3–0 | Pro League · Belgium |
| 2021-04-10 | PonferradinavFuenlabradaLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-04-10 | Pacos FerreiravBenficaPrimeira Liga · Portugal | 0–5 | Primeira Liga · Portugal |
| 2021-04-10 | NecaxavUNAM PumasLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-04-10 | FK RostovvRubin KazanPremier League · Russia | 0–1 | Premier League · Russia |
| 2021-04-10 | ScunthorpevTranmereLeague Two · England | 0–0 | League Two · England |
| 2021-04-10 | RizesporvTrabzonsporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2021-04-10 | BrechinvAlbion RvsLeague Two · Scotland | 2–4 | League Two · Scotland |
| 2021-04-09 | HamburgvDarmstadt2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2021-04-09 | PortimonensevGuimaraesPrimeira Liga · Portugal | 3–0 | Primeira Liga · Portugal |
| 2021-04-09 | WislavRakowEkstraklasa · Poland | 1–2 | Ekstraklasa · Poland |
| 2021-04-09 | HeartsvAlloaChampionship · Scotland | 6–0 | Championship · Scotland |
| 2021-04-09 | HuescavElcheLa Liga · Spain | 3–1 | La Liga · Spain |
| 2021-04-09 | Din. BucurestivAcademica ClinceniSuperliga · Romania | 1–3 | Superliga · Romania |
| 2021-04-09 | FC ArgesvChindia TargovisteSuperliga · Romania | 3–1 | Superliga · Romania |
| 2021-04-09 | JagielloniavCracoviaEkstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2021-04-09 | ReggianavEmpoliSerie B · Italy | 0–1 | Serie B · Italy |
| 2021-04-09 | VitessevDen HaagEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2021-04-09 | FulhamvWolvesPremier League · England | 0–1 | Premier League · England |
| 2021-04-09 | WatfordvReadingChampionship · England | 2–0 | Championship · England |
| 2021-04-09 | TenerifevSp GijonLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-04-09 | St. PatricksvDerry CityPremier Division · Ireland | 2–0 | Premier Division · Ireland |
| 2021-04-09 | OldhamvColchesterLeague Two · England | 5–2 | League Two · England |
| 2021-04-09 | FC VoluntarivFC BotosaniSuperliga · Romania | 1–1 | Superliga · Romania |
| 2021-04-09 | OdensevVejleSuperliga · Denmark | 0–1 | Superliga · Denmark |
| 2021-04-09 | BielefeldvFreiburgBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2021-04-09 | EupenvStandardPro League · Belgium | 0–4 | Pro League · Belgium |
| 2021-04-09 | AstravUTA AradSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-04-09 | MetzvLilleLigue 1 · France | 0–2 | Ligue 1 · France |
| 2021-04-09 | MansfieldvNewport CountyLeague Two · England | 1–1 | League Two · England |
| 2021-04-09 | DundalkvBohemiansPremier Division · Ireland | 0–1 | Premier Division · Ireland |
| 2021-04-08 | DumbartonvEast FifeLeague One · Scotland | 2–1 | League One · Scotland |
| 2021-04-08 | ClydevForfarLeague One · Scotland | 3–0 | League One · Scotland |
| 2021-04-08 | StenhousemuirvCowdenbeathLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2021-04-08 | Viitorul ConstantavPoli IasiSuperliga · Romania | 1–2 | Superliga · Romania |
| 2021-04-08 | DenizlisporvKasimpasaSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-04-08 | HannovervWurzburger Kickers2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2021-04-08 | GaziantepvBuyuksehyrSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2021-04-08 | Yeni MalatyasporvFenerbahceSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-04-07 | Beerschot VAvCharleroiPro League · Belgium | 2–1 | Pro League · Belgium |
| 2021-04-07 | AntalyasporvSivassporSüper Lig · Turkey | 2–4 | Süper Lig · Turkey |
| 2021-04-07 | GenclerbirligivErzurum BBSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-04-07 | FC TokyovHokkaido Consadole SapporoJ1 League · Japan | 2–1 | J1 League · Japan |
| 2021-04-07 | Shimizu S-PulsevUrawa RedsJ1 League · Japan | 0–2 | J1 League · Japan |
| 2021-04-07 | Gamba OsakavAvispa FukuokaJ1 League · Japan | 0–0 | J1 League · Japan |
| 2021-04-07 | Kawasaki FrontalevSagan TosuJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-04-07 | IntervSassuoloSerie A · Italy | 2–1 | Serie A · Italy |
| 2021-04-07 | KonyasporvAnkaragucuSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-04-07 | Yokohama FCvSanfrecce HiroshimaJ1 League · Japan | 0–3 | J1 League · Japan |
| 2021-04-07 | Vissel KobevOita TrinitaJ1 League · Japan | 1–0 | J1 League · Japan |