| 2021-04-10 | BirminghamvStokeChampionship · England | 2–0 | Championship · England |
| 2021-04-10 | LeccevSpalSerie B · Italy | 1–2 | Serie B · Italy |
| 2021-04-10 | SunderlandvCharltonLeague One · England | 1–2 | League One · England |
| 2021-04-10 | AtromitosvLarisaSuper League · Greece | 0–1 | Super League · Greece |
| 2021-04-10 | LuganovLausanneSuper League · Switzerland | 1–0 | Super League · Switzerland |
| 2021-04-10 | AccringtonvAFC WimbledonLeague One · England | 1–5 | League One · England |
| 2021-04-10 | Pau FCvClermontLigue 2 · France | 2–1 | Ligue 2 · France |
| 2021-04-10 | AyrvDunfermlineChampionship · Scotland | 1–1 | Championship · Scotland |
| 2021-04-10 | BarnsleyvMiddlesbroughChampionship · England | 2–0 | Championship · England |
| 2021-04-10 | AscolivMonzaSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-04-10 | For SittardvFC EmmenEredivisie · Netherlands | 1–3 | Eredivisie · Netherlands |
| 2021-04-10 | CowdenbeathvElginLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2021-04-10 | Defensa y JusticiavTalleres CordobaCopa De La Liga Profesional · Argentina | 2–2 | Copa De La Liga Profesional · Argentina |
| 2021-04-10 | MotherwellvSt MirrenPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2021-04-10 | Sepsi Sf. GheorghevFCSBSuperliga · Romania | 1–1 | Superliga · Romania |
| 2021-04-10 | Raith RvsvArbroathChampionship · Scotland | 2–2 | Championship · Scotland |
| 2021-04-10 | BoltonvHarrogateLeague Two · England | 2–1 | League Two · England |
| 2021-04-10 | AtlasvClub LeonLiga MX · Mexico | 1–3 | Liga MX · Mexico |
| 2021-04-10 | BournemouthvCoventryChampionship · England | 4–1 | Championship · England |
| 2021-04-10 | AdmiravRiedBundesliga · Austria | 0–2 | Bundesliga · Austria |
| 2021-04-10 | IpswichvMilton Keynes DonsLeague One · England | 0–0 | League One · England |
| 2021-04-10 | ParmavMilanSerie A · Italy | 1–3 | Serie A · Italy |
| 2021-04-10 | SpeziavCrotoneSerie A · Italy | 3–2 | Serie A · Italy |
| 2021-04-10 | MillwallvSwanseaChampionship · England | 0–3 | Championship · England |
| 2021-04-10 | PlatensevSan LorenzoCopa De La Liga Profesional · Argentina | 2–4 | Copa De La Liga Profesional · Argentina |
| 2021-04-10 | PrestonvBrentfordChampionship · England | 0–5 | Championship · England |
| 2021-04-10 | ZwollevTwenteEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-04-10 | BoavistavRio AvePrimeira Liga · Portugal | 3–3 | Primeira Liga · Portugal |
| 2021-04-10 | MaritimovFarensePrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2021-04-10 | EastleighvWokingNational League · England | 0–0 | National League · England |
| 2021-04-10 | MechelenvWaregemPro League · Belgium | 4–2 | Pro League · Belgium |
| 2021-04-10 | KhimkivTambovPremier League · Russia | 1–0 | Premier League · Russia |
| 2021-04-10 | Slask WroclawvLechia GdanskEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-04-10 | Ath BilbaovAlavesLa Liga · Spain | 0–0 | La Liga · Spain |
| 2021-04-10 | VallecanovGironaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-04-10 | Paris FCvTroyesLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-04-10 | OrebrovGoteborgAllsvenskan · Sweden | 0–0 | Allsvenskan · Sweden |
| 2021-04-10 | Bayern MunichvUnion BerlinBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-04-10 | NorthamptonvBristol RvsLeague One · England | 1–1 | League One · England |
| 2021-04-10 | UdinesevTorinoSerie A · Italy | 0–1 | Serie A · Italy |
| 2021-04-10 | ValenciennesvChamblyLigue 2 · France | 2–1 | Ligue 2 · France |
| 2021-04-10 | StuttgartvDortmundBundesliga · Germany | 2–3 | Bundesliga · Germany |
| 2021-04-10 | Malmo FFvHammarbyAllsvenskan · Sweden | 3–2 | Allsvenskan · Sweden |
| 2021-04-10 | ApollonvOFI CreteSuper League · Greece | 0–0 | Super League · Greece |
| 2021-04-10 | TorquayvWeymouthNational League · England | 2–1 | National League · England |
| 2021-04-10 | PlymouthvHullLeague One · England | 0–3 | League One · England |
| 2021-04-10 | AltrinchamvHalifaxNational League · England | 0–1 | National League · England |
| 2021-04-10 | Port ValevMorecambeLeague Two · England | 1–0 | League Two · England |
| 2021-04-10 | GillinghamvShrewsburyLeague One · England | 0–0 | League One · England |
| 2021-04-10 | UfavAkhmat GroznyPremier League · Russia | 3–0 | Premier League · Russia |