| 2021-04-10 | LuzernvBaselSuper League · Switzerland | 3–4 | Super League · Switzerland |
| 2021-04-10 | DerbyvNorwichChampionship · England | 0–1 | Championship · England |
| 2021-04-10 | TondelavPortoPrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2021-04-10 | Real MadridvBarcelonaLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-04-10 | Virtus EntellavSalernitanaSerie B · Italy | 0–3 | Serie B · Italy |
| 2021-04-10 | Man CityvLeedsPremier League · England | 1–2 | Premier League · England |
| 2021-04-10 | Fleetwood TownvRochdaleLeague One · England | 1–0 | League One · England |
| 2021-04-10 | Estudiantes L.P.vAldosiviCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2021-04-10 | Crystal PalacevChelseaPremier League · England | 1–4 | Premier League · England |
| 2021-04-10 | BresciavPescaraSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-04-10 | SwindonvPeterboroLeague One · England | 0–3 | League One · England |
| 2021-04-10 | LongfordvDroghedaPremier Division · Ireland | 0–4 | Premier Division · Ireland |
| 2021-04-10 | GalatasarayvKaragumrukSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-04-10 | EibarvLevanteLa Liga · Spain | 0–1 | La Liga · Spain |
| 2021-04-10 | PeterheadvPartickLeague One · Scotland | 0–3 | League One · Scotland |
| 2021-04-10 | BromleyvDag and RedNational League · England | 1–0 | National League · England |
| 2021-04-10 | MontpelliervMarseilleLigue 1 · France | 3–3 | Ligue 1 · France |
| 2021-04-10 | NancyvSochauxLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-04-10 | SalfordvStevenageLeague Two · England | 2–1 | League Two · England |
| 2021-04-10 | StranraervEdinburgh CityLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2021-04-10 | CardiffvBlackburnChampionship · England | 2–2 | Championship · England |
| 2021-04-10 | AltachvSt. PoltenBundesliga · Austria | 1–0 | Bundesliga · Austria |
| 2021-04-10 | Finn HarpsvWaterfordPremier Division · Ireland | 2–1 | Premier Division · Ireland |
| 2021-04-10 | Werder BremenvRB LeipzigBundesliga · Germany | 1–4 | Bundesliga · Germany |
| 2021-04-10 | ForfarvEast FifeLeague One · Scotland | 1–2 | League One · Scotland |
| 2021-04-10 | Boreham WoodvWealdstoneNational League · England | 3–1 | National League · England |
| 2021-04-10 | Sligo RoversvShamrock RoversPremier Division · Ireland | 1–1 | Premier Division · Ireland |
| 2021-04-10 | FalkirkvClydeLeague One · Scotland | 2–1 | League One · Scotland |
| 2021-04-10 | CambridgevExeterLeague Two · England | 1–4 | League Two · England |
| 2021-04-10 | DoncastervWiganLeague One · England | 1–4 | League One · England |
| 2021-04-10 | DundeevMortonChampionship · Scotland | 1–1 | Championship · Scotland |
| 2021-04-10 | Annan AthleticvStirlingLeague Two · Scotland | 1–2 | League Two · Scotland |
| 2021-04-10 | Queen of SthvInverness CChampionship · Scotland | 1–1 | Championship · Scotland |
| 2021-04-10 | HuddersfieldvRotherhamChampionship · England | 0–0 | Championship · England |
| 2021-04-10 | OviedovLas PalmasLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-04-10 | NiortvAuxerreLigue 2 · France | 0–4 | Ligue 2 · France |
| 2021-04-10 | PaderbornvBochum2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2021-04-10 | St JohnstonevAberdeenPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2021-04-10 | Warta PoznanvStal MielecEkstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2021-04-10 | Le HavrevAjaccioLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-04-10 | BradfordvGrimsbyLeague Two · England | 1–0 | League Two · England |
| 2021-04-10 | Cerezo OsakavAvispa FukuokaJ1 League · Japan | 2–2 | J1 League · Japan |
| 2021-04-10 | WalsallvForest GreenLeague Two · England | 2–1 | League Two · England |
| 2021-04-10 | CremonesevPordenoneSerie B · Italy | 2–1 | Serie B · Italy |
| 2021-04-10 | GrenoblevCaenLigue 2 · France | 3–1 | Ligue 2 · France |
| 2021-04-10 | HartbergvAustria ViennaBundesliga · Austria | 1–0 | Bundesliga · Austria |
| 2021-04-10 | KilmarnockvRoss CountyPremiership · Scotland | 2–2 | Premiership · Scotland |
| 2021-04-10 | LiverpoolvAston VillaPremier League · England | 2–1 | Premier League · England |
| 2021-04-10 | LincolnvBlackpoolLeague One · England | 2–2 | League One · England |
| 2021-04-10 | WrexhamvStockportNational League · England | 0–3 | National League · England |