| 2021-04-11 | FC KolnvMainzBundesliga · Germany | 2–3 | Bundesliga · Germany |
| 2021-04-11 | SonderjyskevHorsensSuperliga · Denmark | 2–3 | Superliga · Denmark |
| 2021-04-11 | HalmstadvHackenAllsvenskan · Sweden | 1–0 | Allsvenskan · Sweden |
| 2021-04-11 | PatronatovGimnasia L.P.Copa De La Liga Profesional · Argentina | 4–1 | Copa De La Liga Profesional · Argentina |
| 2021-04-11 | Sheffield UnitedvArsenalPremier League · England | 0–3 | Premier League · England |
| 2021-04-11 | VillarrealvOsasunaLa Liga · Spain | 1–2 | La Liga · Spain |
| 2021-04-11 | UtrechtvFeyenoordEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2021-04-11 | FC TokyovKawasaki FrontaleJ1 League · Japan | 2–4 | J1 League · Japan |
| 2021-04-11 | Argentinos JrsvCentral CordobaCopa De La Liga Profesional · Argentina | 0–0 | Copa De La Liga Profesional · Argentina |
| 2021-04-11 | Waasland-BeverenvKortrijkPro League · Belgium | 3–4 | Pro League · Belgium |
| 2021-04-11 | ZurichvServetteSuper League · Switzerland | 1–2 | Super League · Switzerland |
| 2021-04-11 | Sagan TosuvYokohama FCJ1 League · Japan | 3–0 | J1 League · Japan |
| 2021-04-11 | SK RapidvSalzburgBundesliga · Austria | 0–3 | Bundesliga · Austria |
| 2021-04-11 | RennesvNantesLigue 1 · France | 1–0 | Ligue 1 · France |
| 2021-04-11 | LensvLorientLigue 1 · France | 4–1 | Ligue 1 · France |
| 2021-04-11 | IntervCagliariSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-04-11 | Hokkaido Consadole SapporovKashima AntlersJ1 League · Japan | 2–2 | J1 League · Japan |
| 2021-04-11 | AnkaragucuvGenclerbirligiSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-04-11 | Beerschot VAvOostendePro League · Belgium | 1–2 | Pro League · Belgium |
| 2021-04-10 | Volos NFCvPanetolikosSuper League · Greece | 3–1 | Super League · Greece |
| 2021-04-10 | MaidenheadvBarnetNational League · England | 0–0 | National League · England |
| 2021-04-10 | SouthendvCrawley TownLeague Two · England | 0–0 | League Two · England |
| 2021-04-10 | Pogon SzczecinvWisla PlockEkstraklasa · Poland | 2–0 | Ekstraklasa · Poland |
| 2021-04-10 | ChateaurouxvDunkerqueLigue 2 · France | 1–2 | Ligue 2 · France |
| 2021-04-10 | HartlepoolvNotts CountyNational League · England | 2–0 | National League · England |
| 2021-04-10 | Sanfrecce HiroshimavShonan BellmareJ1 League · Japan | 0–1 | J1 League · Japan |
| 2021-04-10 | GetafevCadizLa Liga · Spain | 0–1 | La Liga · Spain |
| 2021-04-10 | QPRvSheffield WedsChampionship · England | 4–1 | Championship · England |
| 2021-04-10 | CrewevOxfordLeague One · England | 0–6 | League One · England |
| 2021-04-10 | BarrowvCarlisleLeague Two · England | 2–2 | League Two · England |
| 2021-04-10 | Bristol CityvNott'm ForestChampionship · England | 0–0 | Championship · England |
| 2021-04-10 | GentvCharleroiPro League · Belgium | 4–0 | Pro League · Belgium |
| 2021-04-10 | HamiltonvDundee UnitedPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2021-04-10 | HeraclesvWillem IIEredivisie · Netherlands | 4–0 | Eredivisie · Netherlands |
| 2021-04-10 | PortsmouthvBurtonLeague One · England | 1–2 | League One · England |
| 2021-04-10 | AZ AlkmaarvSparta RotterdamEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2021-04-10 | Ein FrankfurtvWolfsburgBundesliga · Germany | 4–3 | Bundesliga · Germany |
| 2021-04-10 | WycombevLutonChampionship · England | 1–3 | Championship · England |
| 2021-04-10 | JuarezvAtl. San LuisLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-04-10 | CheltenhamvLeyton OrientLeague Two · England | 1–0 | League Two · England |
| 2021-04-10 | HerthavM'gladbachBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2021-04-10 | MontrosevAirdrie UtdLeague One · Scotland | 2–2 | League One · Scotland |
| 2021-04-10 | Kings LynnvChesterfieldNational League · England | 1–2 | National League · England |
| 2021-04-10 | CelticvLivingstonPremiership · Scotland | 6–0 | Premiership · Scotland |
| 2021-04-10 | StrasbourgvParis SGLigue 1 · France | 1–4 | Ligue 1 · France |
| 2021-04-10 | Erzgebirge AuevSt Pauli2. Bundesliga · Germany | 1–3 | 2. Bundesliga · Germany |
| 2021-04-10 | HataysporvGoztepSüper Lig · Turkey | 2–3 | Süper Lig · Turkey |
| 2021-04-10 | StenhousemuirvQueens ParkLeague Two · Scotland | 1–3 | League Two · Scotland |
| 2021-04-10 | Cove RangersvDumbartonLeague One · Scotland | 1–0 | League One · Scotland |
| 2021-04-10 | FrosinonevCittadellaSerie B · Italy | 1–1 | Serie B · Italy |