| 2021-04-11 | SampdoriavNapoliSerie A · Italy | 0–2 | Serie A · Italy |
| 2021-04-11 | St EtiennevBordeauxLigue 1 · France | 4–1 | Ligue 1 · France |
| 2021-04-11 | WaalwijkvAjaxEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2021-04-11 | Vissel KobevShimizu S-PulseJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-04-11 | Sp BragavBelenensesPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2021-04-11 | Sp LisbonvFamalicaoPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2021-04-11 | GroningenvHeerenveenEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2021-04-11 | AmiensvRodezLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-04-11 | Union de Santa FevBoca JuniorsCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2021-04-11 | VeronavLazioSerie A · Italy | 0–1 | Serie A · Italy |
| 2021-04-11 | Racing ClubvIndependienteCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2021-04-11 | ZaragozavAlmeriaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-04-11 | Dynamo MoscowvUralPremier League · Russia | 2–2 | Premier League · Russia |
| 2021-04-11 | Wurzburger KickersvNurnberg2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-04-11 | AarhusvMidtjyllandSuperliga · Denmark | 1–4 | Superliga · Denmark |
| 2021-04-11 | NicevReimsLigue 1 · France | 0–0 | Ligue 1 · France |
| 2021-04-11 | NorrkopingvSiriusAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2021-04-11 | VaduzvSionSuper League · Switzerland | 3–0 | Super League · Switzerland |
| 2021-04-11 | SabadellvCartagenaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-04-11 | Rosario CentralvBanfieldCopa De La Liga Profesional · Argentina | 3–1 | Copa De La Liga Profesional · Argentina |
| 2021-04-11 | ArisvAEKSuper League · Greece | 1–3 | Super League · Greece |
| 2021-04-11 | BrestvNimesLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-04-11 | Cruz AzulvGuadalajara ChivasLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-04-11 | EspanolvLeganesLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-04-11 | MallorcavLugoLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-04-11 | Erzurum BBvBesiktasSüper Lig · Turkey | 2–4 | Süper Lig · Turkey |
| 2021-04-11 | OlympiakosvPanathinaikosSuper League · Greece | 3–1 | Super League · Greece |
| 2021-04-11 | TottenhamvMan UnitedPremier League · England | 1–3 | Premier League · England |
| 2021-04-11 | Asteras TripolisvPAOKSuper League · Greece | 1–1 | Super League · Greece |
| 2021-04-11 | Lokomotiv MoscowvSpartak MoscowPremier League · Russia | 2–0 | Premier League · Russia |
| 2021-04-11 | GenkvSt TruidenPro League · Belgium | 4–0 | Pro League · Belgium |
| 2021-04-11 | BetisvAth MadridLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-04-11 | Urawa RedsvTokushimaJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-04-11 | RangersvHibernianPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2021-04-11 | Young BoysvSt. GallenSuper League · Switzerland | 2–0 | Super League · Switzerland |
| 2021-04-11 | LASKvWolfsberger ACBundesliga · Austria | 2–1 | Bundesliga · Austria |
| 2021-04-11 | VVV VenlovPSV EindhovenEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2021-04-11 | ZaglebievPodbeskidzieEkstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2021-04-11 | KayserisporvAntalyasporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-04-11 | ValladolidvGranadaLa Liga · Spain | 1–2 | La Liga · Spain |
| 2021-04-11 | Lech PoznanvLegiaEkstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2021-04-11 | RegginavVicenzaSerie B · Italy | 3–0 | Serie B · Italy |
| 2021-04-11 | Randers FCvNordsjaellandSuperliga · Denmark | 3–4 | Superliga · Denmark |
| 2021-04-11 | LyonvAngersLigue 1 · France | 3–0 | Ligue 1 · France |
| 2021-04-11 | TolucavMonterreyLiga MX · Mexico | 1–2 | Liga MX · Mexico |
| 2021-04-11 | HannovervHeidenheim2. Bundesliga · Germany | 1–3 | 2. Bundesliga · Germany |
| 2021-04-11 | Sturm GrazvTirolBundesliga · Austria | 3–2 | Bundesliga · Austria |
| 2021-04-11 | FiorentinavAtalantaSerie A · Italy | 2–3 | Serie A · Italy |
| 2021-04-11 | MjallbyvVarbergAllsvenskan · Sweden | 0–0 | Allsvenskan · Sweden |
| 2021-04-11 | BurnleyvNewcastlePremier League · England | 1–2 | Premier League · England |