| 2008-11-25 | Port ValevBarnetLeague Two · England | 0–0 | League Two · England |
| 2008-11-25 | NorthamptonvLeedsLeague One · England | 2–1 | League One · England |
| 2008-11-25 | SwindonvPeterboroLeague One · England | 2–2 | League One · England |
| 2008-11-25 | CheltenhamvSouthendLeague One · England | 0–0 | League One · England |
| 2008-11-25 | BirminghamvIpswichChampionship · England | 2–1 | Championship · England |
| 2008-11-25 | HartlepoolvBristol RvsLeague One · England | 1–1 | League One · England |
| 2008-11-25 | StockportvBrightonLeague One · England | 2–0 | League One · England |
| 2008-11-24 | SetubalvBelenensesPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2008-11-24 | SassuolovModenaSerie B · Italy | 3–0 | Serie B · Italy |
| 2008-11-24 | Hansa RostockvMunich 18602. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2008-11-24 | WiganvEvertonPremier League · England | 1–0 | Premier League · England |
| 2008-11-24 | BarnsleyvBurnleyChampionship · England | 3–2 | Championship · England |
| 2008-11-23 | KonyasporvKayserisporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2008-11-23 | ElchevSalamancaLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2008-11-23 | TorinovMilanSerie A · Italy | 2–2 | Serie A · Italy |
| 2008-11-23 | XanthivArisSuper League · Greece | 1–1 | Super League · Greece |
| 2008-11-23 | AZ AlkmaarvAjaxEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2008-11-23 | FreiburgvKoblenz2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2008-11-23 | HamburgvWerder BremenBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2008-11-23 | AlavesvGironaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2008-11-23 | RegginavAtalantaSerie A · Italy | 3–1 | Serie A · Italy |
| 2008-11-23 | GentvGenkPro League · Belgium | 2–3 | Pro League · Belgium |
| 2008-11-23 | ChievovSienaSerie A · Italy | 0–2 | Serie A · Italy |
| 2008-11-23 | NurnbergvGreuther Furth2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2008-11-23 | Willem IIvGroningenEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2008-11-23 | NumanciavAth MadridLa Liga · Spain | 1–1 | La Liga · Spain |
| 2008-11-23 | GuimaraesvPacos FerreiraPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2008-11-23 | NantesvNancyLigue 1 · France | 0–1 | Ligue 1 · France |
| 2008-11-23 | LaziovGenoaSerie A · Italy | 1–1 | Serie A · Italy |
| 2008-11-23 | BolognavPalermoSerie A · Italy | 1–1 | Serie A · Italy |
| 2008-11-23 | YorkvCrawley TownNational League · England | 2–2 | National League · England |
| 2008-11-23 | WehenvOberhausen2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2008-11-23 | NacionalvTrofensePrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2008-11-23 | MainzvSt Pauli2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2008-11-23 | BarcelonavGetafeLa Liga · Spain | 1–1 | La Liga · Spain |
| 2008-11-23 | UtrechtvVitesseEredivisie · Netherlands | 4–0 | Eredivisie · Netherlands |
| 2008-11-23 | LevantevCeltaLa Liga 2 · Spain | 1–3 | La Liga 2 · Spain |
| 2008-11-23 | LeccevRomaSerie A · Italy | 0–3 | Serie A · Italy |
| 2008-11-23 |  MonacovLe MansLigue 1 · France | 3–0 | Ligue 1 · France |
| 2008-11-23 | OsasunavAlmeriaLa Liga · Spain | 3–1 | La Liga · Spain |
| 2008-11-23 | SociedadvHuescaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2008-11-23 | SunderlandvWest HamPremier League · England | 0–1 | Premier League · England |
| 2008-11-23 | VallecanovAlicanteLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2008-11-23 | Sp GijonvBetisLa Liga · Spain | 1–2 | La Liga · Spain |
| 2008-11-23 | PanioniosvLevadeiakosSuper League · Greece | 1–0 | Super League · Greece |
| 2008-11-23 | NapolivCagliariSerie A · Italy | 2–2 | Serie A · Italy |
| 2008-11-23 | BesiktasvEskisehirsporSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2008-11-23 | La CorunavAth BilbaoLa Liga · Spain | 3–1 | La Liga · Spain |
| 2008-11-23 | AugsburgvKaiserslautern 2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2008-11-23 | AcademicavBenficaPrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |