| 2021-12-28 | MoreirensevEstorilPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2021-12-28 | MaritimovVizelaPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2021-12-28 | EastleighvTorquayNational League · England | 2–1 | National League · England |
| 2021-12-28 | Dag and RedvAldershotNational League · England | 1–0 | National League · England |
| 2021-12-28 | Wuhan FCvQingdao FCSuper League · China | 1–1 | Super League · China |
| 2021-12-28 | SolihullvStockportNational League · England | 0–1 | National League · England |
| 2021-12-28 | TondelavGil VicentePrimeira Liga · Portugal | 0–3 | Primeira Liga · Portugal |
| 2021-12-28 | WokingvDover AthleticNational League · England | 3–2 | National League · England |
| 2021-12-27 | St TruidenvEupenPro League · Belgium | 2–0 | Pro League · Belgium |
| 2021-12-27 | DerbyvWest BromChampionship · England | 1–0 | Championship · England |
| 2021-12-27 | KayserisporvSivassporSüper Lig · Turkey | 3–0 | Süper Lig · Turkey |
| 2021-12-27 | NewcastlevMan UnitedPremier League · England | 1–1 | Premier League · England |
| 2021-12-27 | MechelenvSeraingPro League · Belgium | 2–0 | Pro League · Belgium |
| 2021-12-27 | DoncastervSunderlandLeague One · England | 0–3 | League One · England |
| 2021-12-27 | CharleroivOud-Heverlee LeuvenPro League · Belgium | 0–3 | Pro League · Belgium |
| 2021-12-27 | KonyasporvBesiktasSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2021-12-27 | Beerschot VAvAnderlechtPro League · Belgium | 0–7 | Pro League · Belgium |
| 2021-12-27 | QPRvBournemouthChampionship · England | 0–1 | Championship · England |
| 2021-12-26 | Guangzhou FCvBeijing GuoanSuper League · China | 1–0 | Super League · China |
| 2021-12-26 | Aston VillavChelseaPremier League · England | 1–3 | Premier League · England |
| 2021-12-26 | AyrvRaith RvsChampionship · Scotland | 2–0 | Championship · Scotland |
| 2021-12-26 | HamiltonvKilmarnockChampionship · Scotland | 2–3 | Championship · Scotland |
| 2021-12-26 | Dover AthleticvDag and RedNational League · England | 0–2 | National League · England |
| 2021-12-26 | West HamvSouthamptonPremier League · England | 2–3 | Premier League · England |
| 2021-12-26 | Airdrie UtdvAlloaLeague One · Scotland | 3–1 | League One · Scotland |
| 2021-12-26 | AlanyasporvKaragumrukSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-12-26 | Shanghai PortvShenzhenSuper League · China | 3–1 | Super League · China |
| 2021-12-26 | Changchun YataivGuangzhou CitySuper League · China | 2–1 | Super League · China |
| 2021-12-26 | Fleetwood TownvShrewsburyLeague One · England | 0–3 | League One · England |
| 2021-12-26 | TorquayvYeovilNational League · England | 3–0 | National League · England |
| 2021-12-26 | TranmerevBarrowLeague Two · England | 2–0 | League Two · England |
| 2021-12-26 | TottenhamvCrystal PalacePremier League · England | 3–0 | Premier League · England |
| 2021-12-26 | AberdeenvDundeePremiership · Scotland | 2–1 | Premiership · Scotland |
| 2021-12-26 | RizesporvGaziantepSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-12-26 | Cercle BruggevClub BruggePro League · Belgium | 2–0 | Pro League · Belgium |
| 2021-12-26 | ForfarvStenhousemuirLeague Two · Scotland | 3–4 | League Two · Scotland |
| 2021-12-26 | RangersvSt MirrenPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2021-12-26 | Annan AthleticvKelty HeartsLeague Two · Scotland | 5–1 | League Two · Scotland |
| 2021-12-26 | FalkirkvClydeLeague One · Scotland | 1–2 | League One · Scotland |
| 2021-12-26 |  Thailandv VietnamAFF Championship | 0–0 | AFF Championship |
| 2021-12-26 | MiddlesbroughvNott'm ForestChampionship · England | 2–0 | Championship · England |
| 2021-12-26 | Cove RangersvEast FifeLeague One · Scotland | 4–2 | League One · Scotland |
| 2021-12-26 | AldershotvWokingNational League · England | 1–1 | National League · England |
| 2021-12-26 | Man CityvLeicesterPremier League · England | 6–3 | Premier League · England |
| 2021-12-26 | StockportvAltrinchamNational League · England | 5–1 | National League · England |
| 2021-12-26 | Albion RvsvStranraerLeague Two · Scotland | 3–2 | League Two · Scotland |
| 2021-12-26 | StandardvWaregemPro League · Belgium | 0–1 | Pro League · Belgium |
| 2021-12-26 | BrightonvBrentfordPremier League · England | 2–0 | Premier League · England |
| 2021-12-26 | GoztepvAd. DemirsporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-12-26 | HeartsvRoss CountyPremiership · Scotland | 2–1 | Premiership · Scotland |