| 2021-12-22 | Willem IIvNijmegenEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2021-12-18 | AZ AlkmaarvWillem IIEredivisie · Netherlands | 4–1 | Eredivisie · Netherlands |
| 2021-12-10 | Willem IIvCambuurEredivisie · Netherlands | 1–3 | Eredivisie · Netherlands |
| 2021-12-02 | AjaxvWillem IIEredivisie · Netherlands | 5–0 | Eredivisie · Netherlands |
| 2021-11-27 | Willem IIvGo Ahead EaglesEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2021-11-21 | HeerenveenvWillem IIEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2021-11-06 | Willem IIvSparta RotterdamEredivisie · Netherlands | 0–3 | Eredivisie · Netherlands |
| 2021-10-31 | UtrechtvWillem IIEredivisie · Netherlands | 5–1 | Eredivisie · Netherlands |
| 2021-10-22 | Willem IIvFor SittardEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-10-17 | TwentevWillem IIEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-10-02 | HeraclesvWillem IIEredivisie · Netherlands | 3–2 | Eredivisie · Netherlands |
| 2021-09-25 | Willem IIvPSV EindhovenEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2021-09-21 | WaalwijkvWillem IIEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2021-09-18 | Willem IIvGroningenEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2021-09-12 | NijmegenvWillem IIEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2021-08-28 | Willem IIvZwolleEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-08-22 | VitessevWillem IIEredivisie · Netherlands | 0–3 | Eredivisie · Netherlands |
| 2021-08-15 | Willem IIvFeyenoordEredivisie · Netherlands | 0–4 | Eredivisie · Netherlands |
| 2021-05-16 | Willem IIvFor SittardEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2021-05-13 | Den HaagvWillem IIEredivisie · Netherlands | 1–4 | Eredivisie · Netherlands |
| 2021-05-09 | Willem IIvPSV EindhovenEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2021-05-01 | UtrechtvWillem IIEredivisie · Netherlands | 3–2 | Eredivisie · Netherlands |
| 2021-04-23 | Willem IIvWaalwijkEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-04-10 | HeraclesvWillem IIEredivisie · Netherlands | 4–0 | Eredivisie · Netherlands |
| 2021-04-03 | Willem IIvAZ AlkmaarEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2021-03-21 | VitessevWillem IIEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2021-03-13 | Willem IIvHeerenveenEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2021-03-06 | TwentevWillem IIEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-02-28 | Sparta RotterdamvWillem IIEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2021-02-24 | Willem IIvDen HaagEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-02-19 | Willem IIvUtrechtEredivisie · Netherlands | 0–6 | Eredivisie · Netherlands |
| 2021-02-14 | FeyenoordvWillem IIEredivisie · Netherlands | 5–0 | Eredivisie · Netherlands |
| 2021-01-31 | Willem IIvFC EmmenEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2021-01-28 | AjaxvWillem IIEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2021-01-22 | Willem IIvZwolleEredivisie · Netherlands | 1–3 | Eredivisie · Netherlands |
| 2021-01-17 | WaalwijkvWillem IIEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-01-14 | Willem IIvGroningenEredivisie · Netherlands | 2–3 | Eredivisie · Netherlands |
| 2021-01-10 | VVV VenlovWillem IIEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2020-12-23 | Willem IIvAjaxEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2020-12-20 | AZ AlkmaarvWillem IIEredivisie · Netherlands | 5–3 | Eredivisie · Netherlands |
| 2020-12-13 | Willem IIvSparta RotterdamEredivisie · Netherlands | 1–3 | Eredivisie · Netherlands |
| 2020-12-05 | For SittardvWillem IIEredivisie · Netherlands | 3–2 | Eredivisie · Netherlands |
| 2020-11-29 | GroningenvWillem IIEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2020-11-21 | Willem IIvVVV VenloEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2020-11-08 | PSV EindhovenvWillem IIEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2020-10-31 | Willem IIvVitesseEredivisie · Netherlands | 1–3 | Eredivisie · Netherlands |
| 2020-10-24 | ZwollevWillem IIEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2020-10-17 | Willem IIvTwenteEredivisie · Netherlands | 0–3 | Eredivisie · Netherlands |
| 2020-10-04 | Willem IIvFeyenoordEredivisie · Netherlands | 1–4 | Eredivisie · Netherlands |
| 2020-09-27 | FC EmmenvWillem IIEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |