| 2021-04-13 | WeymouthvAldershotNational League · England | 0–3 | National League · England |
| 2021-04-12 | KasimpasavYeni MalatyasporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2021-04-12 | AIKvDegerforsAllsvenskan · Sweden | 2–0 | Allsvenskan · Sweden |
| 2021-04-12 | ChievovPisaSerie B · Italy | 2–0 | Serie B · Italy |
| 2021-04-12 | BrightonvEvertonPremier League · England | 0–0 | Premier League · England |
| 2021-04-12 | Poli IasivFC HermannstadtSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-04-12 | River PlatevColon Santa FECopa De La Liga Profesional · Argentina | 3–2 | Copa De La Liga Profesional · Argentina |
| 2021-04-12 | CSKA MoscowvR. VolgogradPremier League · Russia | 2–0 | Premier League · Russia |
| 2021-04-12 | MouscronvAntwerpPro League · Belgium | 2–3 | Pro League · Belgium |
| 2021-04-12 | LanusvNewells Old BoysCopa De La Liga Profesional · Argentina | 1–3 | Copa De La Liga Profesional · Argentina |
| 2021-04-12 | BeneventovSassuoloSerie A · Italy | 0–1 | Serie A · Italy |
| 2021-04-12 | LyngbyvAalborgSuperliga · Denmark | 2–2 | Superliga · Denmark |
| 2021-04-12 | CeltavSevillaLa Liga · Spain | 3–4 | La Liga · Spain |
| 2021-04-12 | FenerbahcevGaziantepSüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2021-04-12 | HuracanvSarmiento JuninCopa De La Liga Profesional · Argentina | 3–0 | Copa De La Liga Profesional · Argentina |
| 2021-04-12 | Viitorul ConstantavGaz Metan MediasSuperliga · Romania | 0–2 | Superliga · Romania |
| 2021-04-12 | Piast GliwicevGornik Z.Ekstraklasa · Poland | 2–0 | Ekstraklasa · Poland |
| 2021-04-12 | AlcorconvCastellonLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-04-12 | HoffenheimvLeverkusenBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2021-04-12 | AlanyasporvDenizlisporSüper Lig · Turkey | 3–2 | Süper Lig · Turkey |
| 2021-04-12 | QueretarovSantos LagunaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-04-12 | West BromvSouthamptonPremier League · England | 3–0 | Premier League · England |
| 2021-04-12 | GianninavLamiaSuper League · Greece | 1–2 | Super League · Greece |
| 2021-04-12 | GuingampvToulouseLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-04-12 | Club TijuanavMazatlan FCLiga MX · Mexico | 2–3 | Liga MX · Mexico |
| 2021-04-12 | KalmarvOstersundsAllsvenskan · Sweden | 0–0 | Allsvenskan · Sweden |
| 2021-04-11 | Arsenal TulavKrasnodarPremier League · Russia | 1–0 | Premier League · Russia |
| 2021-04-11 | Oita TrinitavNagoya GrampusJ1 League · Japan | 0–3 | J1 League · Japan |
| 2021-04-11 | Santa ClaravNacionalPrimeira Liga · Portugal | 5–1 | Primeira Liga · Portugal |
| 2021-04-11 | SochivZenitPremier League · Russia | 1–2 | Premier League · Russia |
| 2021-04-11 | Gil VicentevMoreirensePrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2021-04-11 | West HamvLeicesterPremier League · England | 3–2 | Premier League · England |
| 2021-04-11 | Vegalta SendaivYokohama F. MarinosJ1 League · Japan | 0–0 | J1 League · Japan |
| 2021-04-11 | MirandesvLogronesLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-04-11 | Godoy CruzvArsenal SarandiCopa De La Liga Profesional · Argentina | 2–3 | Copa De La Liga Profesional · Argentina |
| 2021-04-11 | Tigres UANLvClub AmericaLiga MX · Mexico | 1–3 | Liga MX · Mexico |
| 2021-04-11 | OsnabruckvBraunschweig2. Bundesliga · Germany | 0–4 | 2. Bundesliga · Germany |
| 2021-04-11 | Kashiwa ReysolvGamba OsakaJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-04-11 | RomavBolognaSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-04-11 | SivassporvKonyasporSüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2021-04-11 | Univ. CraiovavCFR ClujSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-04-11 | MalagavAlbaceteLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-04-11 | ValenciavSociedadLa Liga · Spain | 2–2 | La Liga · Spain |
| 2021-04-11 | VeneziavCosenzaSerie B · Italy | 3–0 | Serie B · Italy |
| 2021-04-11 | BrondbyvFC CopenhagenSuperliga · Denmark | 1–3 | Superliga · Denmark |
| 2021-04-11 | JuventusvGenoaSerie A · Italy | 3–1 | Serie A · Italy |
| 2021-04-11 | Schalke 04vAugsburgBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2021-04-11 | ElfsborgvDjurgardenAllsvenskan · Sweden | 0–2 | Allsvenskan · Sweden |
| 2021-04-11 |  MonacovDijonLigue 1 · France | 3–0 | Ligue 1 · France |
| 2021-04-11 | AnderlechtvClub BruggePro League · Belgium | 2–1 | Pro League · Belgium |