| 2018-04-02 | CarlislevLincolnLeague Two · England | 0–1 | League Two · England |
| 2018-04-02 | SunderlandvSheffield WedsChampionship · England | 1–3 | Championship · England |
| 2018-04-02 | CrewevPort ValeLeague Two · England | 2–2 | League Two · England |
| 2018-04-02 | OldhamvBlackpoolLeague One · England | 2–1 | League One · England |
| 2018-04-02 | LensvChateaurouxLigue 2 · France | 2–1 | Ligue 2 · France |
| 2018-04-02 | WrexhamvBoreham WoodNational League · England | 0–1 | National League · England |
| 2018-04-02 | FoggiavEmpoliSerie B · Italy | 0–3 | Serie B · Italy |
| 2018-04-02 | LuzernvSt. GallenSwiss Super League · Switzerland | 3–1 | Swiss Super League · Switzerland |
| 2018-04-02 | HartlepoolvGuiseleyNational League · England | 0–1 | National League · England |
| 2018-04-01 | UralvRubin KazanRussian Premier League · Russia | 1–1 | Russian Premier League · Russia |
| 2018-04-01 | Werder BremenvEin FrankfurtBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2018-04-01 | TrelleborgsvGoteborgAllsvenskan · Sweden | 1–3 | Allsvenskan · Sweden |
| 2018-04-01 | Seattle SoundersvCF MontrealMLS · United States | 0–1 | MLS · United States |
| 2018-04-01 | QueretarovPueblaLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2018-04-01 | Boca JuniorsvTalleres CordobaLiga Profesional · Argentina | 2–1 | Liga Profesional · Argentina |
| 2018-04-01 | Sporting Kansas CityvDC UnitedMLS · United States | 1–0 | MLS · United States |
| 2018-04-01 | NantesvSt EtienneLigue 1 · France | 0–3 | Ligue 1 · France |
| 2018-04-01 | StrasbourgvMetzLigue 1 · France | 2–2 | Ligue 1 · France |
| 2018-04-01 | IndependientevAtl. TucumanLiga Profesional · Argentina | 0–2 | Liga Profesional · Argentina |
| 2018-04-01 | VVV VenlovTwenteEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2018-04-01 | ApollonvLarisaSuper League Greece · Greece | 3–0 | Super League Greece · Greece |
| 2018-04-01 | ArsenalvStokePremier League · England | 3–0 | Premier League · England |
| 2018-04-01 | DundeevHeartsPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2018-04-01 | RegensburgvErzgebirge Aue2. Bundesliga · Germany | 1–3 | 2. Bundesliga · Germany |
| 2018-04-01 | IwatavUrawa RedsJ1 League · Japan | 2–1 | J1 League · Japan |
| 2018-04-01 | Greuther FurthvUnion Berlin2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2018-04-01 | FCSBvPoli IasiLiga I · Romania | 1–0 | Liga I · Romania |
| 2018-04-01 | Tigres UANLvClub LeonLiga MX · Mexico | 4–1 | Liga MX · Mexico |
| 2018-04-01 | LyonvToulouseLigue 1 · France | 2–0 | Ligue 1 · France |
| 2018-04-01 | Club AmericavCruz AzulLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2018-04-01 | BochumvBraunschweig2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2018-04-01 | KrasnodarvFK Anzi MakhackalaRussian Premier League · Russia | 1–1 | Russian Premier League · Russia |
| 2018-04-01 | GalatasarayvTrabzonsporSüper Lig · Türkiye | 2–1 | Süper Lig · Türkiye |
| 2018-04-01 | LorcavGranadaLaLiga 2 · Spain | 3–2 | LaLiga 2 · Spain |
| 2018-04-01 | FK RostovvCSKA MoscowRussian Premier League · Russia | 1–2 | Russian Premier League · Russia |
| 2018-04-01 | GroningenvAjaxEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2018-04-01 | HeraclesvHeerenveenEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2018-04-01 | GimnasticvLugoLaLiga 2 · Spain | 3–0 | LaLiga 2 · Spain |
| 2018-04-01 | FeyenoordvExcelsiorEredivisie · Netherlands | 5–0 | Eredivisie · Netherlands |
| 2018-04-01 | Houston DynamovNew England RevolutionMLS · United States | 0–2 | MLS · United States |
| 2018-04-01 | VallecanovCadizLaLiga 2 · Spain | 1–1 | LaLiga 2 · Spain |
| 2018-04-01 | OstersundsvDjurgardenAllsvenskan · Sweden | 0–1 | Allsvenskan · Sweden |
| 2018-04-01 | MainzvM'gladbachBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2018-04-01 | LillevAmiensLigue 1 · France | 0–1 | Ligue 1 · France |
| 2018-04-01 | UNAM PumasvNecaxaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2018-04-01 | MalagavVillarrealLaLiga · Spain | 1–0 | LaLiga · Spain |
| 2018-04-01 | ChelseavTottenhamPremier League · England | 1–3 | Premier League · England |
| 2018-04-01 | LeganesvValenciaLaLiga · Spain | 0–1 | LaLiga · Spain |
| 2018-04-01 | PanioniosvXanthiSuper League Greece · Greece | 0–0 | Super League Greece · Greece |
| 2018-04-01 | St PaulivSandhausen2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |