| 2021-04-15 | PartickvMontroseLeague One · Scotland | 5–0 | League One · Scotland |
| 2021-04-15 | JuarezvTigres UANLLiga MX · Mexico | 2–3 | Liga MX · Mexico |
| 2021-04-15 | ClydevDumbartonLeague One · Scotland | 0–1 | League One · Scotland |
| 2021-04-15 | StranraervStenhousemuirLeague Two · Scotland | 4–0 | League Two · Scotland |
| 2021-04-15 | RotherhamvCoventryChampionship · England | 0–1 | Championship · England |
| 2021-04-14 | OsnabruckvRegensburg2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2021-04-14 | VallecanovMirandesLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-04-14 | Kawasaki FrontalevAvispa FukuokaJ1 League · Japan | 3–1 | J1 League · Japan |
| 2021-04-14 | Nagoya GrampusvSanfrecce HiroshimaJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-04-14 | Sagan TosuvGamba OsakaJ1 League · Japan | 0–1 | J1 League · Japan |
| 2021-04-14 | Cerezo OsakavTokushimaJ1 League · Japan | 1–2 | J1 League · Japan |
| 2021-04-14 | ClermontvAmiensLigue 2 · France | 3–0 | Ligue 2 · France |
| 2021-04-13 | AFC WimbledonvIpswichLeague One · England | 3–0 | League One · England |
| 2021-04-13 | DoncastervBurtonLeague One · England | 0–3 | League One · England |
| 2021-04-13 | BradfordvCrawley TownLeague Two · England | 0–2 | League Two · England |
| 2021-04-13 | Queens ParkvAnnan AthleticLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2021-04-13 | WokingvBromleyNational League · England | 3–4 | National League · England |
| 2021-04-13 | BarrowvExeterLeague Two · England | 2–1 | League Two · England |
| 2021-04-13 | RotherhamvQPRChampionship · England | 3–1 | Championship · England |
| 2021-04-13 | CremonesevEmpoliSerie B · Italy | 2–2 | Serie B · Italy |
| 2021-04-13 | StockportvKings LynnNational League · England | 4–0 | National League · England |
| 2021-04-13 | LincolnvMilton Keynes DonsLeague One · England | 4–0 | League One · England |
| 2021-04-13 | WiganvSunderlandLeague One · England | 2–1 | League One · England |
| 2021-04-13 | Derry CityvShamrock RoversPremier Division · Ireland | 0–2 | Premier Division · Ireland |
| 2021-04-13 | Newport CountyvCarlisleLeague Two · England | 0–0 | League Two · England |
| 2021-04-13 | Airdrie UtdvForfarLeague One · Scotland | 3–1 | League One · Scotland |
| 2021-04-13 | OxfordvShrewsburyLeague One · England | 4–1 | League One · England |
| 2021-04-13 | StenhousemuirvElginLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2021-04-13 | Atl. TucumanvVelez SarsfieldCopa De La Liga Profesional · Argentina | 2–0 | Copa De La Liga Profesional · Argentina |
| 2021-04-13 | MorecambevScunthorpeLeague Two · England | 4–1 | League Two · England |
| 2021-04-13 | SalfordvBoltonLeague Two · England | 0–1 | League Two · England |
| 2021-04-13 | Dag and RedvEastleighNational League · England | 2–0 | National League · England |
| 2021-04-13 | SuttonvTorquayNational League · England | 0–1 | National League · England |
| 2021-04-13 | Sheffield WedsvSwanseaChampionship · England | 0–2 | Championship · England |
| 2021-04-13 | HuddersfieldvBournemouthChampionship · England | 1–2 | Championship · England |
| 2021-04-13 | Edinburgh CityvBrechinLeague Two · Scotland | 2–1 | League Two · Scotland |
| 2021-04-13 | BlackpoolvAccringtonLeague One · England | 0–0 | League One · England |
| 2021-04-13 | WalsallvTranmereLeague Two · England | 1–0 | League Two · England |
| 2021-04-13 | Albion RvsvCowdenbeathLeague Two · Scotland | 0–0 | League Two · Scotland |
| 2021-04-13 | ChesterfieldvBoreham WoodNational League · England | 0–0 | National League · England |
| 2021-04-13 | CrewevPortsmouthLeague One · England | 0–0 | League One · England |
| 2021-04-13 | HarrogatevLeyton OrientLeague Two · England | 2–2 | League Two · England |
| 2021-04-13 | StirlingvStranraerLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2021-04-13 | HalifaxvWrexhamNational League · England | 0–4 | National League · England |
| 2021-04-13 | PartickvClydeLeague One · Scotland | 2–0 | League One · Scotland |
| 2021-04-13 | Queen of SthvRaith RvsChampionship · Scotland | 0–1 | Championship · Scotland |
| 2021-04-13 | DunfermlinevDundeeChampionship · Scotland | 0–0 | Championship · Scotland |
| 2021-04-13 | PachucavPueblaLiga MX · Mexico | 1–3 | Liga MX · Mexico |
| 2021-04-13 | SolihullvNotts CountyNational League · England | 2–1 | National League · England |
| 2021-04-13 | RochdalevSwindonLeague One · England | 2–1 | League One · England |