| 2022-04-02 | AldershotvEastleighNational League · England | 0–2 | National League · England |
| 2022-04-02 | Man UnitedvLeicesterPremier League · England | 1–1 | Premier League · England |
| 2022-04-02 | LamiavOFI CreteSuper League · Greece | 1–2 | Super League · Greece |
| 2022-04-02 | Krylya SovetovvUfaPremier League · Russia | 1–2 | Premier League · Russia |
| 2022-04-02 | StranraervForfarLeague Two · Scotland | 0–2 | League Two · Scotland |
| 2022-04-02 | WaalwijkvUtrechtEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2022-04-02 | CeltavReal MadridLa Liga · Spain | 1–2 | La Liga · Spain |
| 2022-04-02 | Racing ClubvSarmiento JuninCopa De La Liga Profesional · Argentina | 4–1 | Copa De La Liga Profesional · Argentina |
| 2022-04-02 | Vissel KobevKyotoJ1 League · Japan | 1–3 | J1 League · Japan |
| 2022-04-02 | LASKvRiedBundesliga · Austria | 0–2 | Bundesliga · Austria |
| 2022-04-02 | HibernianvDundee UnitedPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2022-04-02 | AltayvAntalyasporSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2022-04-02 | GalatasarayvKaragumrukSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2022-04-02 | MansfieldvNorthamptonLeague Two · England | 1–0 | League Two · England |
| 2022-04-02 | CrewevFleetwood TownLeague One · England | 1–3 | League One · England |
| 2022-04-02 | FC VoluntarivFarul ConstantaSuperliga · Romania | 1–0 | Superliga · Romania |
| 2022-04-02 | Boreham WoodvWokingNational League · England | 0–1 | National League · England |
| 2022-04-02 | Lokomotiv MoscowvSpartak MoscowPremier League · Russia | 1–0 | Premier League · Russia |
| 2022-04-02 | Kawasaki FrontalevCerezo OsakaJ1 League · Japan | 1–4 | J1 League · Japan |
| 2022-04-02 | ValenciennesvAmiensLigue 2 · France | 0–2 | Ligue 2 · France |
| 2022-04-02 | ChesterfieldvGrimsbyNational League · England | 1–4 | National League · England |
| 2022-04-02 | DortmundvRB LeipzigBundesliga · Germany | 1–4 | Bundesliga · Germany |
| 2022-04-02 | WaregemvSt TruidenPro League · Belgium | 0–2 | Pro League · Belgium |
| 2022-04-02 | LeccevFrosinoneSerie B · Italy | 1–0 | Serie B · Italy |
| 2022-04-02 | DarmstadtvHolstein Kiel2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2022-04-02 | Yokohama F. MarinosvFC TokyoJ1 League · Japan | 2–1 | J1 League · Japan |
| 2022-04-02 | SJKvHIFKVeikkausliiga · Finland | 2–1 | Veikkausliiga · Finland |
| 2022-04-02 | Atl. San LuisvMazatlan FCLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2022-04-02 | NicevRennesLigue 1 · France | 1–1 | Ligue 1 · France |
| 2022-04-02 | SouthendvNotts CountyNational League · England | 0–3 | National League · England |
| 2022-04-02 | Kashima AntlersvShimizu S-PulseJ1 League · Japan | 2–1 | J1 League · Japan |
| 2022-04-02 | HJKvHonkaVeikkausliiga · Finland | 1–0 | Veikkausliiga · Finland |
| 2022-04-02 | Quevilly RouenvSochauxLigue 2 · France | 0–2 | Ligue 2 · France |
| 2022-04-02 | WiganvBoltonLeague One · England | 1–1 | League One · England |
| 2022-04-02 | Gamba OsakavNagoya GrampusJ1 League · Japan | 3–1 | J1 League · Japan |
| 2022-04-02 | MechelenvKortrijkPro League · Belgium | 3–2 | Pro League · Belgium |
| 2022-04-02 | Columbus CrewvNashville SCMLS · United States | 0–1 | MLS · United States |
| 2022-04-02 | FeyenoordvWillem IIEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2022-04-02 | HackenvAIKAllsvenskan · Sweden | 4–2 | Allsvenskan · Sweden |
| 2022-04-02 | Newport CountyvExeterLeague Two · England | 0–1 | League Two · England |
| 2022-04-02 | CosenzavParmaSerie B · Italy | 1–3 | Serie B · Italy |
| 2022-04-02 | RodezvNiortLigue 2 · France | 1–1 | Ligue 2 · France |
| 2022-04-01 | PatronatovUnion de Santa FeCopa De La Liga Profesional · Argentina | 2–1 | Copa De La Liga Profesional · Argentina |
| 2022-04-01 | Beerschot VAvClub BruggePro League · Belgium | 1–3 | Pro League · Belgium |
| 2022-04-01 | Union BerlinvFC KolnBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2022-04-01 | GironavMalagaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2022-04-01 | Sp BragavBenficaPrimeira Liga · Portugal | 3–2 | Primeira Liga · Portugal |
| 2022-04-01 | Slask WroclawvLech PoznanEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2022-04-01 | DundalkvUC DublinPremier Division · Ireland | 2–0 | Premier Division · Ireland |
| 2022-04-01 | St. PatricksvDroghedaPremier Division · Ireland | 1–1 | Premier Division · Ireland |