| 2021-04-17 | TranmerevSalfordLeague Two · England | 0–0 | League Two · England |
| 2021-04-17 | DundalkvSt. PatricksPremier Division · Ireland | 1–1 | Premier Division · Ireland |
| 2021-04-17 | MonzavCremoneseSerie B · Italy | 2–1 | Serie B · Italy |
| 2021-04-17 | Notts CountyvEastleighNational League · England | 0–1 | National League · England |
| 2021-04-17 | AntwerpvGenkPro League · Belgium | 3–2 | Pro League · Belgium |
| 2021-04-17 | M'gladbachvEin FrankfurtBundesliga · Germany | 4–0 | Bundesliga · Germany |
| 2021-04-17 | Lechia GdanskvPiast GliwiceEkstraklasa · Poland | 2–2 | Ekstraklasa · Poland |
| 2021-04-17 | Shamrock RoversvLongfordPremier Division · Ireland | 2–1 | Premier Division · Ireland |
| 2021-04-17 | GoztepvGalatasaraySüper Lig · Turkey | 1–3 | Süper Lig · Turkey |
| 2021-04-17 | VicenzavLecceSerie B · Italy | 1–2 | Serie B · Italy |
| 2021-04-17 | R. VolgogradvDynamo MoscowPremier League · Russia | 0–3 | Premier League · Russia |
| 2021-04-17 | OxfordvGillinghamLeague One · England | 3–2 | League One · England |
| 2021-04-17 | ShrewsburyvDoncasterLeague One · England | 0–2 | League One · England |
| 2021-04-17 | St. GallenvLuzernSuper League · Switzerland | 0–0 | Super League · Switzerland |
| 2021-04-17 | Union BerlinvStuttgartBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-04-17 | WolfsburgvBayern MunichBundesliga · Germany | 2–3 | Bundesliga · Germany |
| 2021-04-17 | Milton Keynes DonsvPortsmouthLeague One · England | 1–0 | League One · England |
| 2021-04-17 | ValenciennesvGuingampLigue 2 · France | 0–1 | Ligue 2 · France |
| 2021-04-17 | Boca JuniorsvAtl. TucumanCopa De La Liga Profesional · Argentina | 3–1 | Copa De La Liga Profesional · Argentina |
| 2021-04-17 | KrasnodarvZenitPremier League · Russia | 2–2 | Premier League · Russia |
| 2021-04-17 | DenizlisporvErzurum BBSüper Lig · Turkey | 2–3 | Süper Lig · Turkey |
| 2021-04-16 | Derry CityvDroghedaPremier Division · Ireland | 1–1 | Premier Division · Ireland |
| 2021-04-16 | FarensevSp LisbonPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2021-04-16 | Gornik Z.vSlask WroclawEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-04-16 | LillevMontpellierLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-04-16 | EvertonvTottenhamPremier League · England | 2–2 | Premier League · England |
| 2021-04-16 | Hokkaido Consadole SapporovYokohama F. MarinosJ1 League · Japan | 1–3 | J1 League · Japan |
| 2021-04-16 | SpalvAscoliSerie B · Italy | 1–2 | Serie B · Italy |
| 2021-04-16 | GironavZaragozaLa Liga 2 · Spain | 3–0 | La Liga 2 · Spain |
| 2021-04-16 | PeterborovNorthamptonLeague One · England | 3–1 | League One · England |
| 2021-04-16 | AstravDin. BucurestiSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-04-16 | KonyasporvKayserisporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2021-04-16 | GenclerbirligivSivassporSüper Lig · Turkey | 2–3 | Süper Lig · Turkey |
| 2021-04-16 | DarmstadtvGreuther Furth2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2021-04-16 | UTA AradvViitorul ConstantaSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-04-16 | VejlevAalborgSuperliga · Denmark | 1–1 | Superliga · Denmark |
| 2021-04-16 | ReadingvCardiffChampionship · England | 1–1 | Championship · England |
| 2021-04-16 | RB LeipzigvHoffenheimBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2021-04-16 | AntalyasporvRizesporSüper Lig · Turkey | 2–3 | Süper Lig · Turkey |
| 2021-04-16 | BraunschweigvPaderborn2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2021-04-16 | BoavistavPacos FerreiraPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2021-04-16 | BlackburnvDerbyChampionship · England | 2–1 | Championship · England |
| 2021-04-16 | BesiktasvAnkaragucuSüper Lig · Turkey | 2–2 | Süper Lig · Turkey |
| 2021-04-16 | WaterfordvBohemiansPremier Division · Ireland | 0–1 | Premier Division · Ireland |
| 2021-04-16 | Talleres CordobavUnion de Santa FeCopa De La Liga Profesional · Argentina | 3–0 | Copa De La Liga Profesional · Argentina |
| 2021-04-16 | Crawley TownvCheltenhamLeague Two · England | 1–0 | League Two · England |
| 2021-04-16 | FuenlabradavSabadellLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |
| 2021-04-16 | PodbeskidzievPogon SzczecinEkstraklasa · Poland | 0–2 | Ekstraklasa · Poland |
| 2021-04-16 | AldosivivRosario CentralCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2021-04-16 | Velez SarsfieldvHuracanCopa De La Liga Profesional · Argentina | 2–0 | Copa De La Liga Profesional · Argentina |