| 2022-04-02 | HammarbyvHelsingborgAllsvenskan · Sweden | 2–1 | Allsvenskan · Sweden |
| 2022-04-02 | Forest GreenvScunthorpeLeague Two · England | 1–0 | League Two · England |
| 2022-04-02 | BarnetvYeovilNational League · England | 2–2 | National League · England |
| 2022-04-02 | KayserisporvFenerbahceSüper Lig · Turkey | 0–4 | Süper Lig · Turkey |
| 2022-04-02 | PartickvArbroathChampionship · Scotland | 0–0 | Championship · Scotland |
| 2022-04-02 | AZ AlkmaarvVitesseEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2022-04-02 | SionvSt. GallenSuper League · Switzerland | 0–3 | Super League · Switzerland |
| 2022-04-02 | ChelseavBrentfordPremier League · England | 1–4 | Premier League · England |
| 2022-04-02 | HalifaxvWealdstoneNational League · England | 2–0 | National League · England |
| 2022-04-02 | Hokkaido Consadole SapporovUrawa RedsJ1 League · Japan | 1–1 | J1 League · Japan |
| 2022-04-02 | TwentevPSV EindhovenEredivisie · Netherlands | 3–3 | Eredivisie · Netherlands |
| 2022-04-02 | FC CincinnativCF MontrealMLS · United States | 3–4 | MLS · United States |
| 2022-04-02 | Ein FrankfurtvGreuther FurthBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2022-04-02 | PlymouthvOxfordLeague One · England | 1–0 | League One · England |
| 2022-04-02 | BournemouthvBristol CityChampionship · England | 3–2 | Championship · England |
| 2022-04-02 | LutonvMillwallChampionship · England | 2–2 | Championship · England |
| 2022-04-02 | BurnleyvMan CityPremier League · England | 0–2 | Premier League · England |
| 2022-04-02 | SpeziavVeneziaSerie A · Italy | 1–0 | Serie A · Italy |
| 2022-04-02 | WalsallvLeyton OrientLeague Two · England | 0–2 | League Two · England |
| 2022-04-02 | Kashiwa ReysolvIwataJ1 League · Japan | 2–0 | J1 League · Japan |
| 2022-04-02 | FK RostovvPari NNPremier League · Russia | 1–2 | Premier League · Russia |
| 2022-04-02 | Godoy CruzvEstudiantes L.P.Copa De La Liga Profesional · Argentina | 3–3 | Copa De La Liga Profesional · Argentina |
| 2022-04-02 | DerbyvPrestonChampionship · England | 1–0 | Championship · England |
| 2022-04-02 | Pau FCvLe HavreLigue 2 · France | 2–1 | Ligue 2 · France |
| 2022-04-02 | Hansa RostockvSt Pauli2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2022-04-02 | Ham-KamvLillestromEliteserien · Norway | 2–2 | Eliteserien · Norway |
| 2022-04-02 | HannovervRegensburg2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2022-04-02 | WolvesvAston VillaPremier League · England | 2–1 | Premier League · England |
| 2022-04-02 | Albion RvsvElginLeague Two · Scotland | 0–0 | League Two · Scotland |
| 2022-04-02 | NimesvGuingampLigue 2 · France | 0–2 | Ligue 2 · France |
| 2022-04-02 | KuPSvInter TurkuVeikkausliiga · Finland | 2–1 | Veikkausliiga · Finland |
| 2022-04-02 | MoldevValerengaEliteserien · Norway | 1–0 | Eliteserien · Norway |
| 2022-04-02 | Defensa y JusticiavRiver PlateCopa De La Liga Profesional · Argentina | 1–2 | Copa De La Liga Profesional · Argentina |
| 2022-04-02 | Warta PoznanvRakowEkstraklasa · Poland | 0–2 | Ekstraklasa · Poland |
| 2022-04-02 | SolihullvMaidenheadNational League · England | 3–1 | National League · England |
| 2022-04-02 | AroucavGil VicentePrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2022-04-02 | BeneventovPisaSerie B · Italy | 5–1 | Serie B · Italy |
| 2022-04-02 | BelenensesvPortimonensePrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2022-04-02 | WycombevDoncasterLeague One · England | 2–0 | League One · England |
| 2022-04-02 | Ath MadridvAlavesLa Liga · Spain | 4–1 | La Liga · Spain |
| 2022-04-02 | SalernitanavTorinoSerie A · Italy | 0–1 | Serie A · Italy |
| 2022-04-02 | SunderlandvGillinghamLeague One · England | 1–0 | League One · England |
| 2022-04-02 | HarrogatevColchesterLeague Two · England | 1–2 | League Two · England |
| 2022-04-02 | MariehamnvLahtiVeikkausliiga · Finland | 0–0 | Veikkausliiga · Finland |
| 2022-04-02 | GetafevMallorcaLa Liga · Spain | 1–0 | La Liga · Spain |
| 2022-04-02 | OostendevSeraingPro League · Belgium | 2–2 | Pro League · Belgium |
| 2022-04-02 | St JohnstonevLivingstonPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2022-04-02 | Sociedad BvAlcorconLa Liga 2 · Spain | 2–4 | La Liga 2 · Spain |
| 2022-04-02 | CardiffvSwanseaChampionship · England | 0–4 | Championship · England |
| 2022-04-02 | AccringtonvCheltenhamLeague One · England | 4–4 | League One · England |