| 2021-04-17 | Seattle SoundersvMinnesota UnitedMLS · United States | 4–0 | MLS · United States |
| 2021-04-17 | TroyesvCaenLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-04-17 | BrentfordvMillwallChampionship · England | 0–0 | Championship · England |
| 2021-04-17 | ChesterfieldvBromleyNational League · England | 1–2 | National League · England |
| 2021-04-17 | Atl. San LuisvPueblaLiga MX · Mexico | 1–4 | Liga MX · Mexico |
| 2021-04-17 | RodezvParis FCLigue 2 · France | 2–2 | Ligue 2 · France |
| 2021-04-17 | CittadellavChievoSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-04-17 | AltrinchamvSuttonNational League · England | 0–4 | National League · England |
| 2021-04-17 | TrabzonsporvHataysporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-04-17 | Sarmiento JuninvLanusCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2021-04-17 | FreiburgvSchalke 04Bundesliga · Germany | 4–0 | Bundesliga · Germany |
| 2021-04-17 | Orlando CityvAtlanta UtdMLS · United States | 0–0 | MLS · United States |
| 2021-04-17 | StokevPrestonChampionship · England | 0–0 | Championship · England |
| 2021-04-17 | GuimaraesvSanta ClaraPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2021-04-17 | CF MontrealvToronto FCMLS · United States | 4–2 | MLS · United States |
| 2021-04-17 | Yokohama FCvVegalta SendaiJ1 League · Japan | 2–2 | J1 League · Japan |
| 2021-04-17 | ArbroathvAyrChampionship · Scotland | 4–0 | Championship · Scotland |
| 2021-04-17 | Volos NFCvGianninaSuper League · Greece | 1–1 | Super League · Greece |
| 2021-04-17 | LeverkusenvFC KolnBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2021-04-17 | HalifaxvKings LynnNational League · England | 4–2 | National League · England |
| 2021-04-17 | LutonvWatfordChampionship · England | 1–0 | Championship · England |
| 2021-04-17 | WealdstonevHartlepoolNational League · England | 2–7 | National League · England |
| 2021-04-17 | Sheffield WedsvBristol CityChampionship · England | 1–1 | Championship · England |
| 2021-04-17 | AuxerrevNancyLigue 2 · France | 3–2 | Ligue 2 · France |
| 2021-04-17 | LugovAlcorconLa Liga 2 · Spain | 1–3 | La Liga 2 · Spain |
| 2021-04-17 | CastellonvMallorcaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-04-17 | WiganvCreweLeague One · England | 2–0 | League One · England |
| 2021-04-17 | Mazatlan FCvAtlasLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2021-04-17 | PisavCosenzaSerie B · Italy | 3–0 | Serie B · Italy |
| 2021-04-17 | ChamblyvAmiensLigue 2 · France | 2–0 | Ligue 2 · France |
| 2021-04-17 | SwanseavWycombeChampionship · England | 2–2 | Championship · England |
| 2021-04-17 | Los Angeles FCvAustin FCMLS · United States | 2–0 | MLS · United States |
| 2021-04-17 | BarnetvAldershotNational League · England | 3–1 | National League · England |
| 2021-04-17 | Central CordobavRiver PlateCopa De La Liga Profesional · Argentina | 0–5 | Copa De La Liga Profesional · Argentina |
| 2021-04-17 | SionvZurichSuper League · Switzerland | 2–2 | Super League · Switzerland |
| 2021-04-17 | BelenensesvMaritimoPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2021-04-17 | East FifevPeterheadLeague One · Scotland | 2–1 | League One · Scotland |
| 2021-04-17 | Dag and RedvSolihullNational League · England | 3–2 | National League · England |
| 2021-04-17 | CowdenbeathvStirlingLeague Two · Scotland | 1–5 | League Two · Scotland |
| 2021-04-17 | AngersvRennesLigue 1 · France | 0–3 | Ligue 1 · France |
| 2021-04-17 | RakowvLech PoznanEkstraklasa · Poland | 3–1 | Ekstraklasa · Poland |
| 2021-04-17 | WislavWarta PoznanEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2021-04-17 | NewcastlevWest HamPremier League · England | 3–2 | Premier League · England |
| 2021-04-17 | CharleroivEupenPro League · Belgium | 2–3 | Pro League · Belgium |
| 2021-04-17 | Leyton OrientvBarrowLeague Two · England | 2–0 | League Two · England |
| 2021-04-17 | MoreirensevTondelaPrimeira Liga · Portugal | 2–3 | Primeira Liga · Portugal |
| 2021-04-17 | RochdalevAccringtonLeague One · England | 3–1 | League One · England |
| 2021-04-17 | RegginavReggianaSerie B · Italy | 2–1 | Serie B · Italy |
| 2021-04-17 | BurtonvPlymouthLeague One · England | 1–1 | League One · England |
| 2021-04-17 | WokingvWrexhamNational League · England | 0–4 | National League · England |