| 2022-04-02 | StenhousemuirvAnnan AthleticLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2022-04-02 | LegiavLechia GdanskEkstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2022-04-02 | BastiavAuxerreLigue 2 · France | 1–1 | Ligue 2 · France |
| 2022-04-02 | DijonvGrenobleLigue 2 · France | 1–0 | Ligue 2 · France |
| 2022-04-02 | HoffenheimvBochumBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2022-04-02 | EstorilvVizelaPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2022-04-02 | VPSvAC OuluVeikkausliiga · Finland | 2–2 | Veikkausliiga · Finland |
| 2022-04-02 | East FifevAirdrie UtdLeague One · Scotland | 0–2 | League One · Scotland |
| 2022-04-02 | QPRvFulhamChampionship · England | 0–2 | Championship · England |
| 2022-04-02 | Chicago FirevFC DallasMLS · United States | 0–0 | MLS · United States |
| 2022-04-02 | LaziovSassuoloSerie A · Italy | 2–1 | Serie A · Italy |
| 2022-04-02 | Velez SarsfieldvLanusCopa De La Liga Profesional · Argentina | 3–1 | Copa De La Liga Profesional · Argentina |
| 2022-04-02 | FreiburgvBayern MunichBundesliga · Germany | 1–4 | Bundesliga · Germany |
| 2022-04-02 | TenerifevZaragozaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2022-04-02 | CharltonvLincolnLeague One · England | 1–2 | League One · England |
| 2022-04-02 | LillevBordeauxLigue 1 · France | 0–0 | Ligue 1 · France |
| 2022-04-02 | Asteras TripolisvAtromitosSuper League · Greece | 0–0 | Super League · Greece |
| 2022-04-02 | CittadellavTernanaSerie B · Italy | 1–2 | Serie B · Italy |
| 2022-04-02 | Oud-Heverlee LeuvenvAntwerpPro League · Belgium | 0–1 | Pro League · Belgium |
| 2022-04-02 | StevenagevOldhamLeague Two · England | 0–1 | League Two · England |
| 2022-04-02 | ToulousevParis FCLigue 2 · France | 2–1 | Ligue 2 · France |
| 2022-04-02 | Milton Keynes DonsvShrewsburyLeague One · England | 2–0 | League One · England |
| 2022-04-02 | RochdalevSwindonLeague Two · England | 0–0 | League Two · England |
| 2022-04-02 | MorecambevBurtonLeague One · England | 3–0 | League One · England |
| 2022-04-02 | FamalicaovBoavistaPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2022-04-02 | LevantevVillarrealLa Liga · Spain | 2–0 | La Liga · Spain |
| 2022-04-02 | Arsenal TulavAkhmat GroznyPremier League · Russia | 0–0 | Premier League · Russia |
| 2022-04-02 | FalkirkvMontroseLeague One · Scotland | 0–3 | League One · Scotland |
| 2022-04-02 | GiresunsporvSivassporSüper Lig · Turkey | 2–2 | Süper Lig · Turkey |
| 2022-04-02 | BielefeldvStuttgartBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-04-02 | BlackpoolvNott'm ForestChampionship · England | 1–4 | Championship · England |
| 2022-04-02 | CowdenbeathvStirlingLeague Two · Scotland | 0–0 | League Two · Scotland |
| 2022-04-02 | ApollonvPanetolikosSuper League · Greece | 1–0 | Super League · Greece |
| 2022-04-02 | IpswichvCambridgeLeague One · England | 0–1 | League One · England |
| 2022-04-02 | BrightonvNorwichPremier League · England | 0–0 | Premier League · England |
| 2022-04-02 | IonikosvVolos NFCSuper League · Greece | 2–2 | Super League · Greece |
| 2022-04-02 | BarrowvPort ValeLeague Two · England | 1–2 | League Two · England |
| 2022-04-02 | AmorebietavIbizaLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2022-04-02 | CaenvDunkerqueLigue 2 · France | 2–1 | Ligue 2 · France |
| 2022-04-02 | Bristol RvsvBradfordLeague Two · England | 2–1 | League Two · England |
| 2022-04-02 | FC Rapid BucurestivFC BotosaniSuperliga · Romania | 3–0 | Superliga · Romania |
| 2022-04-02 | BarnsleyvReadingChampionship · England | 1–1 | Championship · England |
| 2022-04-02 | Dover AthleticvKings LynnNational League · England | 1–1 | National League · England |
| 2022-04-02 | LeverkusenvHerthaBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2022-04-02 | ValladolidvLugoLa Liga 2 · Spain | 4–1 | La Liga 2 · Spain |
| 2022-04-02 | LecznavPogon SzczecinEkstraklasa · Poland | 0–4 | Ekstraklasa · Poland |
| 2022-04-02 | Ross CountyvHeartsPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2022-04-02 | BanfieldvArgentinos JrsCopa De La Liga Profesional · Argentina | 0–2 | Copa De La Liga Profesional · Argentina |
| 2022-04-02 | DundeevAberdeenPremiership · Scotland | 2–2 | Premiership · Scotland |
| 2022-04-02 | AltachvAdmiraBundesliga · Austria | 2–2 | Bundesliga · Austria |