| 2022-04-03 | KasimpasavGaziantepSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2022-04-03 | ValenciavCadizLa Liga · Spain | 0–0 | La Liga · Spain |
| 2022-04-03 | TolucavPueblaLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2022-04-03 | West HamvEvertonPremier League · England | 2–1 | Premier League · England |
| 2022-04-03 | Philadelphia UnionvCharlotteMLS · United States | 2–0 | MLS · United States |
| 2022-04-03 | EibarvMirandesLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2022-04-03 | St EtiennevMarseilleLigue 1 · France | 2–4 | Ligue 1 · France |
| 2022-04-03 | BetisvOsasunaLa Liga · Spain | 4–1 | La Liga · Spain |
| 2022-04-03 | TrabzonsporvBesiktasSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2022-04-03 | BaselvYoung BoysSuper League · Switzerland | 2–2 | Super League · Switzerland |
| 2022-04-03 | Werder BremenvSandhausen2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2022-04-03 | For SittardvHeraclesEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2022-04-03 | OdensevNordsjaellandSuperliga · Denmark | 2–1 | Superliga · Denmark |
| 2022-04-03 | DC UnitedvAtlanta UtdMLS · United States | 0–1 | MLS · United States |
| 2022-04-03 | CambuurvNijmegenEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2022-04-03 | PonferradinavLas PalmasLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2022-04-03 | AalborgvFC CopenhagenSuperliga · Denmark | 0–1 | Superliga · Denmark |
| 2022-04-03 | BurgosvSp GijonLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2022-04-03 | RangersvCelticPremiership · Scotland | 1–2 | Premiership · Scotland |
| 2022-04-03 | Sp LisbonvPacos FerreiraPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2022-04-03 | GenkvEupenPro League · Belgium | 5–0 | Pro League · Belgium |
| 2022-04-03 | JuventusvInterSerie A · Italy | 0–1 | Serie A · Italy |
| 2022-04-03 | New England RevolutionvNew York Red BullsMLS · United States | 0–1 | MLS · United States |
| 2022-04-03 | LyonvAngersLigue 1 · France | 3–2 | Ligue 1 · France |
| 2022-04-03 | SalzburgvSK RapidBundesliga · Austria | 2–1 | Bundesliga · Austria |
| 2022-04-03 | MontpelliervBrestLigue 1 · France | 1–2 | Ligue 1 · France |
| 2022-04-03 | JuarezvUNAM PumasLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2022-04-02 | ZurichvGrasshoppersSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2022-04-02 | GroningenvAjaxEredivisie · Netherlands | 1–3 | Eredivisie · Netherlands |
| 2022-04-02 | AscolivPordenoneSerie B · Italy | 1–0 | Serie B · Italy |
| 2022-04-02 | HartlepoolvSalfordLeague Two · England | 0–2 | League Two · England |
| 2022-04-02 | Toronto FCvNew York CityMLS · United States | 2–1 | MLS · United States |
| 2022-04-02 | CremonesevRegginaSerie B · Italy | 1–1 | Serie B · Italy |
| 2022-04-02 | LiverpoolvWatfordPremier League · England | 2–0 | Premier League · England |
| 2022-04-02 | Shonan BellmarevSanfrecce HiroshimaJ1 League · Japan | 0–1 | J1 League · Japan |
| 2022-04-02 | CoventryvBlackburnChampionship · England | 2–2 | Championship · England |
| 2022-04-02 | HartbergvTirolBundesliga · Austria | 0–1 | Bundesliga · Austria |
| 2022-04-02 | AlessandriavSpalSerie B · Italy | 2–2 | Serie B · Italy |
| 2022-04-02 | TranmerevCarlisleLeague Two · England | 2–2 | League Two · England |
| 2022-04-02 | HamburgvPaderborn2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2022-04-02 | HakavIlvesVeikkausliiga · Finland | 2–1 | Veikkausliiga · Finland |
| 2022-04-02 | AlloavDumbartonLeague One · Scotland | 2–3 | League One · Scotland |
| 2022-04-02 | LeedsvSouthamptonPremier League · England | 1–1 | Premier League · England |
| 2022-04-02 | Barracas CentralvIndependienteCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2022-04-02 | Sheffield WedsvAFC WimbledonLeague One · England | 2–1 | League One · England |
| 2022-04-02 | ClydevPeterheadLeague One · Scotland | 0–3 | League One · Scotland |
| 2022-04-02 | StokevSheffield UnitedChampionship · England | 1–0 | Championship · England |
| 2022-04-02 | UTA AradvGaz Metan MediasSuperliga · Romania | 4–0 | Superliga · Romania |
| 2022-04-02 | MotherwellvSt MirrenPremiership · Scotland | 4–2 | Premiership · Scotland |
| 2022-04-02 | PeterborovMiddlesbroughChampionship · England | 0–4 | Championship · England |